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Simulation and Optimization Study on Layout Planning of Plant Factory Based on WITNESS
Li Ma,Meiqiong Ma,Chao Ma,Jingwen Deng,Xingluo Liu,Lijun Zhao 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.5
The emergence of plant factory has solved great restriction problem of natural environment in the traditional agriculture. Therefore, it has been the research concentrate on the facility agriculture in recent years. However, the reasonability of factory's production process and layout determines quality of the product, production efficiency and economic benefits. This paper took Wuchang Jingtian Plant Factory as an example, analyzed the production process and layout and provided a corresponding improvement scheme which was verified by the WITNESS simulation software. An optimal solution was determined from the evaluation index of production efficiency, busy rate, production cycle etc.. Besides, the simulation analysis of production cost before and after the improvement verified the improved plant factory operation is effective and feasible. This improvement scheme not only improved efficiency of production system of the plant factory, but also reduced the operating cost.
Li Ma,Xin'an Wu,Yuhui Wei,Yan Zhou,Xiaohua Ma 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
The aim of this study was to investigate the effects of Pluronic F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin. Intestinal permeability of rifampicin with or without excipients was evaluated by an in situ single-pass perfusion method. A highperformance liquid chromatographic method was applied to study the pharmacokinetics of rifampicin with or without excipients. Labrasol or Pluronic F68 (0.1% and 0.05%, v/v), co-perfused with rifampicin (60 μg/mL), significantly increased in situ permeability. Similarly, verapamil (a typical P-gp inhibitor) also increased in situ permeability, but to a lesser extent. In vivo, the oral administration of rifampicin with or without Pluronic F68, Labrasol or verapamil resulted in statistically significant effect on t1/2 (4.83 to 7.75, 6.42 and 7.46 h) and total body clearance (0.46 to 0.26, 0.28, 0.24 L/h/kg). In addition, Pluronic F68, Labrasol and verapamil produced minor changes in AUC_0-t, which improved 1.55-, 1.54-, and 1.73-fold in comparison to control group, respectively. These results showed that Labrasol and Pluronic F68 might inhibit the function of P-gp in the intestine, thereby increasing intestinal absorption and changing the pharmacokinetic parameters of rifampicin. Therefore, excipient selection is an important factor to consider in rational formulation design.