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A Single-Ended 6T1D SRAM Cell With Feedback-fade Write Access for Near-threshold Operation
Kyungho Shin,Jongsun Park 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.11
This paper presents a single-ended 6T1D SRAM cell with a feedback-fade write access (FFWA) for near-threshold operation. FFWA facilitates the single-ended write operation without additional assist circuit or power domain. To speed-up the write operation, drag-down diode is also employed in the empty space of the cell layout. The 6T1D SRAM cell has the minimum area among the various cell topologies supporting decoupled read port. Compared to the conventional 6T SRAM cell, the 6T1D SRAM cell shows 22-46% worst case SNM improvements with only 5.4% area overhead, which is enabled by FFWA and two-by-two zigzag array (TZA) structures. In terms of write-speed, our SRAM cell is 1.34x and 2.12x faster than area-saving 7T and asymmetric 5T cells, respectively. The proposed SRAM cell operates with the supply voltage ranging from 1.1V to 0.45V with 0.53um2 cell area in 40nm CMOS technology.
Half-Select Free and Bit-Line Sharing 9T SRAM for Reliable Supply Voltage Scaling
Kyungho Shin,Woong Choi,Jongsun Park IEEE 2017 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS PART 1 R Vol.64 No.8
<P>This paper presents a half-select free 9T SRAM to facilitate reliable SRAM operation in the near-threshold voltage region. In the proposed SRAM, the half-select disturbance, which results in instable operations in 6T SRAM cell, can be completely eliminated by adopting cross-access selection of row and column word-lines. To minimize the area overhead of the half-select free 9T SRAM cell, a bit-line and access transistors between the adjacent cells are shared using a symmetric shared node that connects two cells. In addition, a selective pre-charge scheme considering the preferably isolated unselected cells has also been proposed to reduce the dynamic power consumption. The simulation results with the most probable failure point method show that the proposed 9T SRAM cell has a minimum operating voltage (V-MIN) of 0.45 V among the half-select free SRAM cells. The test chip with 65-nm CMOS technology shows that the proposed 9T SRAM is fully operated at 0.35 V and 25 degrees C condition. Under the supply voltages between 0.35 and 1.1 V, the 4-kb SRAM macro is operated between 640 kHz and 560 MHz, respectively. The proposed 9T SRAM shows the best voltage scalability without any assist circuit while maintaining small macro area and fast operation frequency.</P>
Shin, Jong-Il,Jeon, Yong-Joon,Lee, Sol,Lee, Yoon Gyeong,Kim, Ji Beom,Lee, Kyungho Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.3
The omega-3 fatty acid docosahexaenoic acid (DHA) is known to induce apoptosis and cell cycle arrest via the induction of reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress in many types of cancers. However, the roles of DHA in drug-resistant cancer cells have not been elucidated. In this study, we investigated the effects of DHA in cisplatin-resistant gastric cancer SNU-601/cis2 cells. DHA was found to induce ROS-dependent apoptosis in these cells. The inositol 1,4,5-triphosphate receptor ($IP_3R$) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis. We also found that G-protein-coupled receptor 120 (GPR120), a receptor of long-chain fatty acids, is expressed in SNU-601/cis2 cells, and the knockdown of GPR120 using specific shRNAs alleviated DHA-mediated ROS production and apoptosis. GPR120 knockdown reduced the expression of ER stress response genes, similar to the case for the pre-treatment of the cells with N-acetyl-L-cysteine (NAC), an ROS scavenger, or 2-APB. Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA. These results suggest that GPR120 mediates DHA-induced apoptosis by regulating $IP_3R$, ROS, and ER stress levels in cisplatin-resistant cancer cells, and that GPR120 is an effective chemotherapeutic target for cisplatin resistance.
Aptamer-Based Pathogen Monitoring for <i>Salmonella enterica</i> ser. Typhimurium
Shin, Woo-Ri,Sekhon, Simranjeet Singh,Kim, Seo-Gyeong,Rhee, Seung Jae,Yang, Gee Na,Won, Kyungho,Rhee, Sung-Keun,Ryu, Hojin,Kim, Kyunghwan,Min, Jiho,Ahn, Ji-Young,Kim, Yang-Hoon American Scientific Publishers 2018 Journal of biomedical nanotechnology Vol.14 No.11