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Comparison of Indomethacin, Diclofenac and Aspirin-Induced Gastric Damage according to Age in Rats
Seo, Pyoung Ju,Kim, Nayoung,Kim, Joo-Hyon,Lee, Byoung Hwan,Nam, Ryoung Hee,Lee, Hye Seung,Park, Ji Hyun,Lee, Mi Kyoung,Chang, Hyun,Jung, Hyun Chae,Song, In Sung The Korean Society of Gastroenterology; the Korean 2012 Gut and Liver Vol.6 No.2
<P><B>Background/Aims</B></P><P>Aging gastric mucosa is known to have decreased mucosal defenses and increased susceptibility to injury by nonsteroidal anti-inflammatory drugs. Depending on the type of nonsteroidal anti-inflammatory drug (NSAID), the underlying mechanisms and the extent of damage to the stomach or intestine may differ. This study was performed to evaluate the acute gastric damage caused by different doses of indomethacin, diclofenac and aspirin in rats of various ages.</P><P><B>Methods</B></P><P>For the acute models, indomethacin (10, 20 or 40 mg/kg), diclofenac (40 or 80 mg/kg) or aspirin (100 mg/kg) was given to 7- and 25-week-old and 1-year-old Sprague-Dawley rats by intragastric gavage. The gross ulcer index, damage area as assessed by imaging, histological index, myeloperoxidase (MPO) activity, and cytosolic phospholipase A<SUB>2</SUB> (cPLA<SUB>2</SUB>) levels were measured after 24 hours.</P><P><B>Results</B></P><P>The gross ulcer index and damage area increased with age in the presence of three NSAIDs (p<0.05). The increases in MPO levels induced by diclofenac and aspirin were significantly higher in 1-year-old than 7-week-old rats (p<0.05). cPLA<SUB>2</SUB> expression induced by indomethacin (10 and 40 mg/kg) was greater in the 1-year-old rats, compared with 7-week-old rats (p<0.05).</P><P><B>Conclusions</B></P><P>NSAID-induced acute gastric damage increased in a dose- and age-dependent manner.</P>
Gymnolaemate Bryozoans in Fresh and Brackish Water of South Korea
Kyoung Jin Jung,Emmy R. Woss,Hyun Sook Chae,Ji Eun Seo 한국동물분류학회 2017 Animal Systematics, Evolution and Diversity Vol.33 No.1
The present census on freshwater bryozoans in the Han River, Geum River and in lentic water bodies in Gangwon Province revealed three gymnolaemate species. Two of them-Hislopia prolixa Hirose and Mawatari, 2011 and Victorella pavida Saville Kent, 1870 were recorded for the first time from South Korea. Paludicella articulata (Ehrenberg, 1831), on the other hand, had already been documented from a few sites since 1941. The bryozoans, all belonging to the order of Ctenostomata, were found on a variety of substrates in freshwater (H. prolixa and P. articulata) and brackish habitats (V. pavida). Hislopia prolixa had recently been established as a new species and this is the first record for an occurrence outside of Japan, where it had been newly described from Lake Biwa and nearby satellite lakes.
In Vitro and in Vivo Evaluation of Phenylbutenoid Dimers as Inhibitors of P-Glycoprotein
Chae, Song Wha,Han, Ah-Reum,Park, Jung Hyun,Rhie, Jeong Yeon,Lim, Hee-Jong,Seo, Eun-Kyoung,Lee, Hwa Jeong American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.12
<P>The expression of P-glycoprotein (P-gp), an ATP-dependent efflux transporter, is closely associated with the failure of chemotherapy and drug absorption. Two synthesized optically active phenylbutenoid dimers, 3<I>S</I>-(3,4-dimethoxyphenyl)-4<I>R</I>-{(<I>E</I>)-3,4-dimethoxystyryl}cyclohex-1-ene (<B>1</B>) and 3<I>R</I>-(3,4-dimethoxyphenyl)-4<I>S</I>-{(<I>E</I>)-3,4-dimethoxystyryl}cyclohex-1-ene (<B>2</B>), were tested for their P-gp inhibitory effects by measuring cellular accumulation and efflux of daunomycin in P-gp-overexpressed human breast cancer cells (MCF-7/ADR). Compound <B>2</B> significantly increased the accumulation of daunomycin (539%) and decreased the efflux of this compound (55.4%), and similar results were observed for <B>1</B>. ATPase assays and Western blot analysis were performed to identify the mechanisms by which compounds <B>1</B> and <B>2</B> inhibit P-gp. In addition, changes in the pharmacokinetic profile of paclitaxel coadministered with <B>2</B> in rats were evaluated. Paclitaxel (25 mg/kg) when orally administered with <B>2</B> (5 mg/kg) improved its relative bioavailability by 185%. Compound <B>2</B> effectively improved cellular accumulation by reducing the efflux of daunomycin and significantly enhanced oral exposure to paclitaxel. Therefore, compound <B>2</B> may be useful for improving oral exposure and cellular availability of drugs that are also substrates of P-gp.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-12/np4004917/production/images/medium/np-2013-004917_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np4004917'>ACS Electronic Supporting Info</A></P>
서수홍,최병주,노치완,신채희,장성훈,김양수,어완규,김효경 고신대학교 의학부 2002 高神大學校 醫學部 論文集 Vol.17 No.1
The POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin change) is a rare multisystemic disorder of unknown pathogenesis. Although the etiology is still unclear, proinflammatory cytokines such as tumor necrosis factor-α, IL-6. and paraprotein specificity for neuroendocrine tissue have been suggested to play a causative role. We report a case of POEMS syndrome presented as progressive sensorimotor neuropathy, hapatosplenomegaly, diabetes mellitus, solitary bone plasmacytoma, hypertrichosis and hyperpigmentation. The patient was treated with local irradiation and prednisolone and showed obvious neurological and systemic improvement.
AHN, Kyoung Kyu,KWON, Donghyeok,JUNG, Kwonil,HA, Yooncheol,SEO, Man Jun,KIM, Sung-Hoon,KIM, Mi-Young,CHO, Kyung-Dong,LEE, Bog-Hieu,CHAE, Chanhee Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.4
<P>The detection and distribution of interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and IL-6 were studied, by <I>in situ </I>hybridization with a non-radioactive digoxigenin-labeled probe, in formalin-fixed, paraffin-embedded lung tissue from 10 pigs naturally infected with <I>Mycoplasma hyopneumoniae</I>. The morphology of host cells was preserved despite the relatively high temperature required during the incubation procedure. Examination of three serial sections from each of the 10 lung samples showed that the three cytokines closely resembled each other in respect of cellular distribution. Three inflammatory cytokines are expressed in response to <I>M. hyopneumoniae </I>infection, with IL-6 localized primarily to peribronchiolar lymphoid hyperplastic tissues, and both IL-1 and TNF-α expressed in alveolar macrophages. Although statistically non-significant, IL-1 (<I>r</I>=0.5744, <I>p</I>=0.0883) showed potentially important correlation with histopatholgical lesions. No other potentially clinically important correlations (<I>r</I>>0.30) were observed between any of the other cytokines (TNF-α; <I>r</I>=0.2045, <I>p</I>=0.5603 and IL-6; <I>r</I>=-0.06607, <I>p</I>=0.8651) and histopathological lesion score. The results suggest that inflammatory cytokines are associated with the development of pneumonia in<I> M. hyopneumoniae</I> infection and may contribute to disease severity.</P>
Kang Kyoung-Ah,Lee Kyoung-Hwa,Chae Sung-Wook,Kim Jeong-Ki,Seo Jung-Yeon,Ham Yong-Ho,Lee Kee-Ho,Kim Bum-Joon,Kim Hee-Sun,Kim Dong-Hyun,Hyun Jin Won The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.1
Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the $G_1$ phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Spl proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity.
싸이클로스포린, 케토코나졸, 0.1% 타크로리무스 연고제제로 병용 치료한 군 사역견의 항문주위 누공 3례
서경원 ( Kyoung Won Seo ),안진옥 ( Jin Ok Ahn ),고예린 ( Ye Rin Coh ),박종우 ( Chong Woo Park ),채지상 ( Ji Sang Chae ),황철용 ( Cheol Yong Hwang ),윤화영 ( Hwa Young Youn ) 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.6
세 마리의 군 사역견이 신체검사와 직장 검사 등을 통해 항문주위 누공으로 진단되었다. 초기 치료는 단기간의 싸이클로스포린과 케토코나졸과 0.1%의 타크로리무스 연고제제로 시작하였다. 병변이 거의 다 치료가 되었을 시점부터 0.1% 타크로리무스 연고제제를 도포 횟수를 줄여서 실시하였다. 세 마리 모두에서 병변은 2-8주 사이에 별다른 부작용을 동반하지 않고 거의 대부분 사라졌으며, 완치는 증례 1, 2, 3에서 각 13, 6, 4주에 이루어졌다. 이 세가지 약물의 병용 프로토콜은 항문낭과도 연결된 항문주위 누공에서도 병변을 해소하는데 효과적이었으며, 특히 초기에 빠른 병변의 해소에 도움이 되어 병변으로부터 발생되는 고통을 경감시켜주는 기간이 늘어나는 것이 강점이라고 할 수 있다. 또한 시간적인 측면 외에도 경제적인 측면에서도 도움이 되므로 개에서 발생하는 항문주위 누공에 효과적인 치료 프로토콜로 유용하게 사용될 수 있을 것으로 사료된다. Three military working dogs (MWDs) were diagnosed with perianal fistulae after a complete physical examination and rectal palpation. The initial treatment protocol was used with short-term oral ciclosporine (CyA) and ketoconazole and 0.1% topical tacrolimus ointment. When lesions were nearly healed, treatment was continued with 0.1% tacrolimus ointment only at a lower frequency. The lesions improved significantly within 2-8 weeks with no noticeable side effects. Complete recovery was determined at weeks 13, 6, and 4 for cases 1, 2, and 3, respectively. This combination protocol was effective at resolving or reducing perianal fistulae (PAF) lesions even communicating with anal sacs in three dogs. The major benefit of this protocol was the rapid reduction of fistulae lesions and this could be helpful to extend the pain-free period. Moreover, this protocol appeared cost-saving as well as time-saving option for PAF dogs.