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이경아 ( Kyeongah Lee ) 아시아문화학술원 2019 인문사회 21 Vol.10 No.1
본 연구는 습지보전법 제정이후 연안습지의 가치에 대해 지역 주민들이 어떻게 인식하고 있는 지를 탐색하는데 목적이 있다. 따라서 보호지역 지정 이후 지역 주민들이 습지보호지역에 대해 어떻게 인식하는지에 대해 살펴보았다. 연구대상은 습지보호지역 주민을 중심으로 SPSS 통계분석을 이용하여 빈도분석과 교차분석을 실시하였다. 본 연구의 결과 지역민들은 습지보호지역의 지정이 매우 유의미하며, ‘지역 활성화 및 소득 향상’ 등을 긍정적 효과로 보았다. 반면에 ‘어업활동 제약’ 등 일상생활에서는 대체적으로 부정적인 영향을 미치고 있다고 판단하였다. 그럼에도 불구하고 습지보호지역의 확대를 원하는 것으로 보아 전반적으로 보호지역 지정이 긍정적으로 작용하고 있음을 알 수 있었다. 따라서 주민의 자발적인 습지의 보전과 현명한 이용을 위해서 해당 지역 주민을 대상으로 체계적인 주민역량강화교육 등이 필요함을 제언한다. This study aims to explore how local residents perceive the value of coastal wetlands since the enactment of the Wetland Conservation Act. Therefore, we have discussed how local residents perceive wetland conservation areas after the designation of protected areas. The subjects of this study were frequency analysis and crossover analysis using SPSS statistical analysis. As a result of this study, local people designated wetland conservation area as very meaningful, and seeing ‘regional activation and income increase’ positively. On the other hand, it was judged that there was a negative impact on daily life such as ‘fishery activity restriction.’ Nonetheless, the desire to expand the wetland protection area indicates that the overall designation of the protected area has a positive effect. Therefore, it is suggested that systematic resident capacity building education is necessary for the residents of the area in order to preserve the welfare of the residents and wise use.
Liang, Zhe Long,Kang, Kyeongah,Yoon, Sukjoon,Huang, Song Mei,Lim, Jae Sung,Kim, Jin Man,Lim, Jong-Seok,Lee, Hyo Jin Raven Press 2012 Annals of Surgical Oncology Vol.19 No.8
<P>Although NDRG2 is a candidate tumor suppressor, its exact role in renal cell carcinoma (RCC) is not fully understood. We investigated the functional role of NDRG2 and its clinical relevance in RCC tumorigenesis.</P>
Nam, Sorim,Kang, Kyeongah,Cha, Jae Seon,Kim, Jung Woo,Lee, Hee Gu,Kim, Yonghwan,Yang, Young,Lee, Myeong-Sok,Lim, Jong-Seok Society for Leukocyte Biology 2016 Journal of leukocyte biology Vol.100 No.6
<P>Myeloid-derived suppressor cells (MDSCs) are immature cells that do not differentiate into mature myeloid cells. Two major populations of PMN-MDSCs (Ly6G(high)Ly6C(low)Gr1(high)CD11b(+)) andMO-MDSCs (Ly6G(-)Ly6C(high)Gr-1(int)CD11b(+)) have an immune suppressive function. Interferon regulatory factor 4 (IRF4) has a role in the negative regulation of TLR signaling and is associated with lymphoid cell development. However, the roles of IRF4 in myeloid cell differentiation are unclear. In this study, we found that IRF4 expression was remarkably suppressed during the development of MDSCs in the tumor microenvironment. Both the mRNA and protein levels of IRF4 in MDSCs were gradually reduced, depending on the development of tumors in the 4T1 model. siRNA-mediated knockdown of IRF4 in bone marrow cells promoted the differentiation of PMN-MDSCs. Similarly, IRF4 inhibition in bone marrow cells using simvastatin, which has been known to inhibit IRF4 expression, increased PMN-MDSC numbers. In contrast, IRF4 overexpression in bone marrow cells inhibited the total numbers of MDSCs, especially PMN-MDSCs. Notably, treatment with IL-4, an upstream regulator of IRF4, induced IRF4 expression in the bone marrow cells, and consequently, IL-4-induced IRF4 expression resulted in a decrease in PMN-MDSC numbers. Finally, we confirmed that IRF4 expression in MDSCs can modulate their activity to inhibit T cell proliferation through IL-10 production and ROS generation, and myeloid-specific deletion of IRF4 leads to the increase of MDSC differentiation. Our present findings indicate that IRF4 reduction induced by tumor formation can increase the number of MDSCs, and increases in the IRF4 expression in MDSCs may infringe on the immune-suppressive function of MDSCs.</P>