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Decreased Osteogenic Differentiation of Mesenchymal Stem Cells in Alcohol-induced Osteonecrosis
Suh, Kuen Tak,Kim, Seung Wook,Roh, Hyoung Lok,Youn, Myung Soo,Jung, Jin Sup Lippincott WilliamsWilkins, Inc. 2005 Clinical orthopaedics and related research Vol.431 No.-
We postulated that osteogenic and adipogenic differentiation ability of the mesenchymal stem cells isolated from the bone marrow could be altered in patients with alcohol-induced osteonecrosis of the femoral head. To examine this hypothesis, we investigated the differentiation ability of the mesenchymal stem cells isolated from the bone marrow from the proximal end of the femur during hip replacements in patients with alcohol-induced osteonecrosis of the femoral head and compared it with the differentiation ability of patients with femoral neck fractures. Marrow was collected from the proximal femurs of 33 patients having hip replacement for either alcohol-induced osteonecrosis of the femoral head or femoral neck fractures. The mesenchymal stem cells were isolated and the culture was expanded from the marrow. The cell populations were compared in terms of the doubling time and the differentiation ability to the osteoblasts and adipocytes. The cells obtained from the patients with alcohol-induced osteonecrosis of the femoral head showed a reduced ability to differentiate the osteogenic lineages compared with the cells obtained from the patients with femoral neck fractures. Such changes may play a role in the development of alcohol-induced osteonecrosis of the femoral head. The altered function of mesenchymal stem cells can be responsible for the pathogenesis of osteonecrosis.
MRI of the proximal femur predicts marrow cellularity and the number of mesenchymal stem cells
Suh, Kuen Tak,Ahn, Jae Min,Lee, Jung Sub,Bae, Jung Yun,Lee, In Suk,Kim, Hak Jin,Jung, Jin Sup Wiley Subscription Services, Inc., A Wiley Company 2012 Journal of magnetic resonance imaging Vol.35 No.1
<P><B>Abstract</B></P><P><B>Purpose:</B></P><P>To determine whether the marrow conversion index (MCI) in MRI is related to the total number of mononuclear and mesenchymal stem cells (MSCs) in proximal femoral metaphysis of patients with hip osteoarthritis.</P><P><B>Materials and Methods:</B></P><P>Thirty‐two hips of 32 consecutive patients who underwent total hip arthroplasty (THA) for hip osteoarthritis were included in this study. MRI of the hip was performed preoperatively and MCI was subsequently calculated. Three‐milliliter bone marrow samples were obtained from the proximal femur during THA and the number of total mononuclear cells was determined using a hemocytometer. Colony forming unit‐fibroblasts (CFU‐Fs) assays of MSCs were performed by transferring a total of 2 × 10<SUP>4</SUP> mononuclear cells to each of five 60‐mm plates. One week later, the numbers of colonies were counted.</P><P><B>Results:</B></P><P>The total number of mononuclear cells decreased with increasing MCI. Likewise, the prevalence and total number of CFU‐Fs increased with increasing number of total mononuclear cells, and decreased with increasing MCI.</P><P><B>Conclusion:</B></P><P>Our results suggest that measurement of MCI in MRI can be an objective and noninvasive method to predict marrow cellularity and the number of MSCs in patients with hip osteoarthritis. J. Magn. Reson. Imaging 2012;35:218‐222. © 2011 Wiley Periodicals, Inc.</P>
Kuen Tak Suh,Chong Il Yoo 대한고관절학회 1993 Hip and Pelvis Vol.5 No.2
Modular designs of hip prosthesis have been popular recently. But, the presence of a nonfixed interface between the plastic cup and the metal backing introduc@ed the additional possibility of postoperative separation of the polyethylene cup from the metal backing, which may be rare cause of irreducible dislocation of the hip. Disassembly of metal-backed modular acetabular components used for total hip arthroplasty is becoming more common. These cases have occurred early in the postoperative period and have been usually associated with dislocation of the femoral component. We report another case of disassembly of a modular acetabular component, which occurred four years after surgery and was not associated with dislocation of the femoral component.