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      저자 : Kouichi Tokunaka (검색결과 1 건)
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        Effects of preselection of genotyped animals on reliability and bias of genomic prediction in dairy cattle

        Kenji Togashi,Kazunori Adachi,Kazuhito Kurogi,Takanori Yasumori,Kouichi Tokunaka,Atsushi Ogino,Yoshiyuki Miyazaki,Toshio Watanabe,Tsutomu Takahashi,Kimihiro Moribe 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.2

        Objective: Models for genomic selection assume that the reference population is an unselected population. However, in practice, genotyped individuals, such as progeny-tested bulls, are highly selected, and the reference population is created after preselection. In dairy cattle, the intensity of selection is higher in males than in females, suggesting that cows can be added to the reference population with less bias and loss of accuracy. The objective is to develop formulas applied to any genomic prediction studies or practice with preselected animals as reference population. Methods: We developed formulas for calculating the reliability and bias of genomically enhanced breeding values (GEBV) in the reference population where individuals are preselected on estimated breeding values. Based on the formulas presented, deterministic simulation was conducted by varying heritability, preselection percentage, and the reference population size. Results: The number of bulls equal to a cow regarding the reliability of GEBV was expressed through a simple formula for the reference population consisting of preselected animals. The bull population was vastly superior to the cow population regarding the reliability of GEBV for low-heritability traits. However, the superiority of reliability from the bull reference population over the cow population decreased as heritability increased. Bias was greater for bulls than cows. Bias and reduction in reliability of GEBV due to preselection was alleviated by expanding reference population. Conclusion: Cows are easier in expanding reference population size compared with bulls and alleviate bias and reduction in reliability of GEBV of bulls which are highly preselected than cows by expanding the cow reference population.

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