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Kiyota, Naomi,Robinson, Bruce,Shah, Manisha,Hoff, Ana O.,Taylor, Matthew H.,Li, Di,Dutcus, Corina E.,Lee, Eun Kyung,Kim, Sung-Bae,Tahara, Makoto Mary Ann Liebert, Inc. 2017 Thyroid Vol.27 No.9
<P><B><I>Background:</I></B> While there is a clear consensus for defining radioiodine-refractory differentiated thyroid cancer (RR-DTC), it is unknown whether these criteria are equally valid for determining when radioiodine (RAI) therapy is no longer beneficial and systemic treatment should be considered. Lenvatinib, a multikinase inhibitor, significantly prolonged progression-free survival (PFS) compared to placebo in a Phase 3 trial in RR-DTC (SELECT; hazard ratio [HR]: 0.21 [99% confidence interval (CI) 0.14–0.31]; <I>p</I> < 0.001). This sub-analysis compared clinical outcomes of lenvatinib-treated patients in SELECT stratified by RR-DTC inclusion criteria.</P><P><B><I>Methods:</I></B> In SELECT, patients with measurable RR-DTC and radiologic evidence of disease progression ≤13 months prior to study entry were randomized 2:1 to lenvatinib (24 mg/day; 28-day cycle) or placebo. In this analysis, patients were stratified based on the following RR-DTC inclusion criteria: no RAI uptake, disease progression within 12 months of RAI therapy despite RAI avidity at the time of treatment, and extensive (>600 mCi) cumulative RAI exposure. All had disease progression as an inclusion criterion for SELECT.</P><P><B><I>Results:</I></B> Of 392 patients (261 lenvatinib; 131 placebo) enrolled, 275, 235, and 73 patients met the inclusion criteria for no RAI uptake, disease progression despite RAI avidity, and extensive RAI exposure, respectively. There was significant overlap between the patient groups, with 167 (42.6%) patients meeting more than one inclusion criterion. Lenvatinib improved median PFS compared to placebo in all groups (“no RAI uptake”: lenvatinib not quantifiable [NQ; CI 14.8–NQ] vs. placebo, 3.7 months [CI 2.5–5.3]; “disease progression despite RAI avidity”: lenvatinib 16.5 months [CI 12.8–NQ] vs. placebo, 3.7 months [CI 1.9–5.4]; “extensive RAI exposure”: lenvatinib 18.7 months [CI 10.7–NQ] vs. placebo, 3.6 months [CI 1.9–5.5]). Objective response rates were 71.8%, 60.0%, and 56.0% for patients with no RAI uptake, disease progression despite RAI avidity, and extensive RAI exposure, respectively. Lenvatinib-related adverse events were similar across groups.</P><P><B><I>Conclusions:</I></B> Comparable efficacy and safety profiles were observed in lenvatinib-treated patients regardless of RR-DTC criteria, possibly because of a large overlap among patients fulfilling each criterion. However, differing definitions for RR-DTC may be equally valid because both lenvatinib and placebo arms exhibited similar PFS outcomes across groups.</P>
Robotics-Mechatronics Design Competition in Kyushu Area, Japan
Taisuke Sakaki,Takanori Kiyota,Hitoshi Kino,Shinichi Sagara,Ryuichi Oguro,Shunji Moromugi,Keiji Imado,Hidetaka Ikeuchi,Manabu Fukushima,Takeshi Ikeda,Kanta Aoki,Nobuhiro Ushimi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
We describe a unique competition based on the novel concept of robotics and mechatronics products that included evaluation of the products’engineering function and interface design. Seventy-seven students of eleven teams from seven universities in the Kyushu area participated in the competition, whose subject was “Health care, life supporting and communication or other technical aids for the elderly or disabled.”Many of the plans presented ideas that balanced function and design, showing the results of collaboration among students studying engineering and students studying product design.