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Lee, Hyo Seon,Oh, Seung Ja,Lee, Kwang-Hoon,Lee, Yoon-Sook,Ko, Eun,Kim, Kyung Eun,Kim, Hyung-chan,Kim, Seokkyun,Song, Paul H.,Kim, Yong-In,Kim, Chungho,Han, Sangyeul American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.45
<P>Angiopoietin-2 (Ang-2) not only regulates angiogenesis by binding to its well known receptor Tie2 on endothelial cells but also controls sprouting of Tie2-negative angiogenic endothelial cells and invasion of Tie2-negative non-endothelial cells by binding to integrins. However, the molecular mechanism of the Ang-2/integrin association has been unclear. In this study, we found that the Gln-362 residue of Ang-2 was essential for binding to α5β1 integrin. A Q362E Ang-2 mutant, which still bound to Tie2, failed to associate with α5β1 integrin and was unable to activate the integrin downstream signaling of focal adhesion kinase. In addition, unlike wild-type Ang-2, the Q362E Ang-2 mutant was defective in mediating invasion of Tie2-negative glioma or Tie2-positive endothelial cells. Furthermore, the tailpiece domain of the α5 subunit in α5β1 integrin was critical for binding to Ang-2. Taken together, these results provide a novel insight into the mechanism of integrin regulation by Ang-2, which contributes to tumor invasion and endothelial cell migration in a Tie2-independent manner.</P>
히트펌프냉풍건조, 복합냉풍건조, 하이브리드 데시칸트건조에 의한 곶감건조 성능비교
박승태(Seungtae Park),김영일(Youngil Kim),이태호(Taeho Lee),홍석균(Seokkyun Hong),김희재(Huejae Kim),김동혁(Donghyuk Kim) 대한설비공학회 2009 대한설비공학회 학술발표대회논문집 Vol.2009 No.-
The persimmons were dried for some test by three systems; the existing heatpump cooling dryer,the mixed desiccant cooling drier and the hybrid desiccant dryer. Therefore, we try to confirm which system can providethe output most through the quantitative analysis of the dryer's performance and running time reduction
이준수(Junsu Lee),박종일(Jongil Park),김세환(Sehwan Kim),박승태(Seungtae Park),홍석균(Seokkyun Hong),최진영(Jinyoung Choi) 대한설비공학회 2009 대한설비공학회 학술발표대회논문집 Vol.2009 No.-
The present study has been conducted to reduce the cold air drying rate. According to the cold air drying method, the quality-excellent product could be made and there would be little change of color, taste and smell. As compared with the hot air drying, the cold air drying equipment has the superior dehumidification in a constant drying zone. However, in a falling drying zone that equipment is not energy-efficient because the drying period could be longer by the dehumidificated.