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Nam Soo Kim,June Sig Sung,Doo Hwa Hong IEEE 2011 IEEE signal processing letters Vol.18 No.2
<P>One of the most popular approaches to parameter adaptation in hidden Markov model (HMM) based systems is the maximum likelihood linear regression (MLLR) technique. In this letter, we extend MLLR to factored MLLR (FMLLR) in which the MLLR parameters depend on a continuous-valued control vector. Since it is practically impossible to estimate the MLLR parameters for each control vector separately, we propose a compact parametric form of the MLLR parameters. In the proposed approach, each MLLR parameter is represented as an inner product between a regression vector and transformed control vector. We present an algorithm to train the FMLLR parameters based on a general framework of the expectation-maximization (EM) algorithm. The proposed approach is applied to adapt the HMM parameters obtained from a database of reading-style speech to singing-style voices while treating the pitches and durations extracted from the musical notes as the control vectors. This enables to efficiently construct a singing voice synthesizer with only a small amount of singing data.</P>
Preoperative Chemoradiation Using Oral Capecitabine in Locally Advanced Rectal Cancer
Kim, Jun-Sang,Kim, Jae-Sung,Cho, Moon-June,Song, Kyu-Sang,Yoon, Wan-Hee 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-
Purpose: Capecitabine (Xeloda) is a new orally administered fluoropyrimidine carbamate that was rationally designed to exert its effect by tumor-selective activation. We attempted to evaluate the efficacy and toxicity of preoperative chemoradiation using capecitabine in locally advanced rectal cancer. Methods and Materials: Between July 1999 and March 2001, 45 patients with locally advanced rectal cancer (cT3/T4 or N+) were treated with preoperative chemoradiation. Radiation of 45 Gy/25 fractions was delivered to the pelvis, followed by a 5.4 Gy/3 fractions boost to the primary tumor. Chemotherapy was administered concurrent with radiotherapy and consisted of 2 cycles of 14-day oral capecitabine (1650 mg/㎡/day) and leucovorin (20 mg/㎡/day), each of which was followed by a 7-day rest period. Surgery was performed 6 weeks after the completion of chemoradiation. Results: Thirty-eight patients received definitive surgery. Primary tumor and node downstaging occurred in 63% and 90% of patients, respectively. The overall downstaging rate, including both primary tumor and nodes, was 84%. A pathologic complete response was achieved in 31% of patients. Twenty-one patients had tumors located initially 5 cm or less from the anal verge; among the 18 treated with surgery, 72% received sphincter-preserving surgery. No Grade 3 or 4 hematologic toxicities developed. Other Grade 3 toxicities were as follows: hand-foot syndrome (7%), fatigue (4%), diarrhea (4%), and radiation dermatitis (2%). Conclusion: These preliminary results suggest that preoperative chemoradiation with capecitabine is a safe, well-tolerated, and effective neoadjuvant treatment modality for locally advanced rectal cancer. In addition, this preoperative treatment has a considerable downstaging effect on the tumor and can increase the possibility of sphincter preservation in distal rectal cancer.
PREOPERATIVE CHEMORADIATION USING ORAL CAPECITABINE IN LOCALLY ADVANCED RECTAL CANCER
Kim, Jun-Sang,Kim, Jae-Sung,Cho, Moon-June,Song, Kyu-Sang,Yoon, Wan-Hee 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.
Purpose: Capecitabine (Xeloda) is a new orally administered fluoropyrimidine carbamate that was rationally designed to exert its effect by tumor-selective activation. We attempted to evaluate the efficacy and toxicity of preoperative chemoradiation using capecitabine in locally advanced rectal cancer. Methods and Materials: Between July 1999 and March 2001, 45 patients with locally advanced rectal cancer (cT3/T4 or N+) were treated with preoperative chemoradiation. Radiation of 45 Gy/25 fractions was delivered to the pelvis, followed by a 5.4 Gy/3 fractions boost to the primary tumor. Chemotherapy was administered concurrent with radiotherapy and consisted of 2 cycles of 14-day oral capecitabine (1650 mg/㎡/day) and leucovorin (20 mg/㎡/day), each of which was followed by a 7-day rest period. Surgery was performed 6 weeks after the completion of chemoradiation. Results: Thirty-eight patients received definitive surgery. Primary tumor and node downstaging occurred in 63% and 90% of patients, respectively. The overall downstaging rate, including both primary tumor and nodes, was 84%. A pathologic complete response was achieved in 31% of patients. Twenty-one patients had tumors located initially 5 cm or less from the anal verge; among the 18 treated with surgery, 72% received sphincter-preserving surgery. No Grade 3 or 4 hematologic toxicities developed. Other Grade 3 toxicities were as follows: hand-foot syndrome (7%), fatigue (4%), diarrhea (4%), and radiation dermatitis (2%). Conclusion: These preliminary results suggest that preoperative chemoradiation with capecitabine is a safe, well-tolerated, and effective neoadjuvant treatment modality for locally advanced rectal cancer. In addition, this preoperative treatment has a considerable downstaging effect on the tumor and can increase the possibility of sphincter preservation in distal rectal cancer.
Kim, Jun-Sang,Lee, Young-Sook,Lee, Jeung-Hoon,Lee, Woong-Hee,Seo, Eun-Young,Cho, Moon-June 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.
Purpose: A number of genes and their products are induced early or late following exposure of cells to ionizing radiation. These radiation-induced genes have various effects on irradiated cells and tissues. Suppression subtractive hybridization (SSH) based on PCR was used to identify the differentially expressed genes by radiation in cervix carcinoma cells. Materials and Methods: Total RNA and poly (A)^(+) mRNA were isolated from irradiated and non-irradiated HeLa cells. Forward- and reverse-subtracted cDNA libraries were constructed using SSH. Eighty-eight clones of each were used to randomly select differentially expressed genes using reverse Northern blotting (dot blot analysis). Northern blotting was used to verify the screened genes. Results: Of the 176 clones, 10 genes in the forward-subtracted library and 9 genes in the reverse-subtracted library were identified as differentially expressed radiation-induced genes by PCR-select differential screening. Three clones from the forward-subtracted library were confirmed by Northern blotting, and showed increased expression in a dose-dependent manner, including a telomerase catalytic subunit and sodium channel-like protein gene, and an ESTs (expressed sequence tags) gene. Conclusion: We identified differentially expressed radiation-induced genes with low-abundance genes with SSH, but further characterization of theses genes are necessary to clarify the biological functions of them. 목적: 자경경부암세포에서 polymeric chain reaction (PCR)원리를 이용한 suppression subtractive hybridization(SSH) 방법으로 방사선조사 시 차등 발현되는 유전자를 동정하고자 하였다. 대상 및 방법: 자궁경부암세포주인 HeLa 세포주에 방사선조사 전과 후 총 RNA와 poly (A)^(+) mRNA를 분리하였다. SSH방법으로 forward 및 reverse-subtracted cDNA Iibranes를 만들었다. 차등 발현된 유전자를screening하기 위해 reverse Northern blotting (dot blot analysis)을 이용하여 각각의 library에서 88개의 클론을 선택하였고 Nothern blotting으로 확인 후 sequencing하였다. 결과: screening상 176개 클론 중 forward-subtracted library에서 10개의 유전자가 reverse-subtracted library에서 9개의 유전자가 동정되었다. forward-subtracted Iibrary로부터 3개의 유전자가 Northern blotting에 의하여 확인되었고 이중 telomerase catalytic subunit and sodium channel-like protein 유전자와 1개의 ESTs (ex-pressed sequence tags) 유전자가 방사선선량에 따라 증가하였다. 결론: 본 연구를 통해 자궁경부암세포주에서 방사선에 의해 유도되는 유전자를 SSH 방법을 통해 동정할 수 있었다. 그러나 이러한 유전자가 어떤 생물학적인 기능을 갖고 있는지에 대한 계속적인 연구가 필요하다.
Kim, Sun-Young,Kim, Jae-Sung,Park, Hee-Sun,Cho, Moon-June,Kim, Ju-Ock,Kim, Jin-Whan,Song, Chang-Jun,Lim, Seung-Pyung,Jung, Sung-Soo 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-
The purpose of this prospective study was to determine whether using magnetic resonance imaging (MRI) for early screening for brain metastases (BM) can improve quality of life, survival in patients with non-small cell lung cancer (NSCLC). The study group comprised 183 patients newly diagnosed with NSCLC. All patients underwent limited brain MRI and routine workups. The control group comprised 131 patients with NSCLC who underwent limited brain MRI only if they had neurologic symptoms. The incidence of BM was 20.8% (38/183) in the study group and 4.6% (6/131) in the control group. The rate of upstaging based on the MRI data was 13.5% (15/111) overall and 15.9% (11/69) in patients that had been considered initially to be resectable surgically. There was no significant difference in survival outcome between the groups. Patients who had BM alone had a greater overall survival time (49 weeks) than those who had multiple systemic metastases (27 weeks; p=0.0307). In conclusions, limited brain MRI appears to be a useful, cost-effective method to screen for BM at the time of initial staging. And it may facilitate timely treatment of patients with NSCLC and improve their survival and quality of life.
Kim, Jong-Eun,Shim, June-Sung,Shin, Yooseok The Korean Academy of Conservative Dentistry 2019 Restorative Dentistry & Endodontics Vol.44 No.3
Endodontic microsurgery is defined as the treatment performed on the root apices of an infected tooth, which was unresolved with conventional root canal therapy. Recently, the advanced technology in 3-dimensional model reconstruction based on computed tomography such as cone beam computed tomography has opened a new avenue in application of personalized, accurate diagnosis and has been increasingly used in the field of dentistry. Nevertheless, direct intra-oral localization of root apex based on the 3-dimensional information is extremely difficult and significant amount of bone removal is inevitable when freehand surgical procedure was employed. Moreover, gingival flap and alveolar bone fenestration are usually required, which leads to prolonged time of surgery, thereby increasing the chance of trauma as well as the risk of infection. The purpose of this case report is to present endodontic microsurgery using the guide template that can accurately target the position of apex for the treatment of an anterior tooth with calcified canal which was untreatable with conventional root canal therapy and unable to track the position of the apex due to the absence of fistula.