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백서 적혈구에서 glutathione이 paraquat 독성에 미치는 영향
김명철,박재윤,채기영,천영욱,박평심,차종희 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2
The participation of superoxide in initiating tissue damage from administration of a xenobiotics is best illustrated by paraquat intoxication, in which it is known that one electron reduction of paraquat leads to the formation of radicals which react with molecular oxygen to give superoxide. In the present study, the effects of paraquat on the level of glutathione and activities of superoxide dismutase(SOD), catalase, glutathione peroxidase, glutathione reductase and glutathione stransferase were investigated in rat liver and erythrocytes. The contents of glutathione in liver and blood were sinificantly decreased by paraquat administration, but the activities of enzymes were unaltered. Incubation of the buffered aerobic mixture of erythrocyte in the presence of 5mM glucose, Paraquat and/or N-ethylmaleimide(NEM) resulted in the formation of lipid peroxide, the activities of various enzyme and the levels of glutathione were determined. The malondialdehyde(MDA) contents as a indicator of lipid peroxidation was decreased and the levels of total glutathione were not changed but the levels of oxidized glutathione(GSSG) were in creased in paraquat treated erythrocytes. The activites of ezyme were decreased in paraquat treated erythrocytes but in reduced glutathione(GSH) treated erythrocyte, the enzymes activities were less decreased by paraquat. These results suggest that paraquat toxicity was probably somewhat reduced by GSH, but paraquat-induced injury were not increased by GSH depletion in erythrocytes.
Ki Cheol Sim,Gi Do Kim,Ho Jung An,Joon Hee Lee,Kyoung Ok Min,Gye Yeop Kim 국제물리치료학회 2011 Journal of International Academy of Physical Ther Vol.2 No.1
This study is intended to examine the tDCS and Montoya stair task(MST) on sensorimotor recovery and glial scar expression in MCAo induced stroke model of rat. To achieve this goal, this study selected 80 SD rats of 8 weeks. The experiment groups were divided them into four groups, and assigned 20 rats to each group. GroupⅠ was a experimental control group; GroupⅡ was a tDCS application group after MCAo; GroupⅢ was a MST application group after MCAo; GroupⅣ was a tDCS and MST application group after MCAo. In each group, neurological function test measurement, motor behavior test, montoya stair task test, immunohistochemistric finding of GFAP expression finding were analyzed. In motor behavior test, the outcome of groupⅠ was significantly difference than the other group, especially from 14days. In montoya stair task test, the outcome of groupⅠ was significantly lower than the other group especially, groupⅡ were significantly different on 14days and group Ⅳ was most significantly difference than the other group. In immunohistochemistric finding, groupⅡ, Ⅲ, Ⅳ were decrease GFAP expression on depend on time stream. These results throughout the MCAo due to focal ischemic brain injury rat model four weeks tDCS and MST was applied, when the neurobehavioural, upper extremity function and ability, histopathologic data suggest that sensorimotor function recovery and a positive influence on glial scar decrease and confirmed that.
Sim, Ki-Cheol,Kim, Gi-Do,Kim, Kyung-Yoon,An, Ho-Jung,Lee, Joon-Hee,Min, Kyoung-Ok,Kim, Gye-Yeop International Academy of Physical Therapy Research 2011 Journal of International Academy of Physical Ther Vol.2 No.1
This study is intended to examine the tDCS and Montoya stair task(MST) on sensorimotor recovery and glial scar expression in MCAo induced stroke model of rat. To achieve this goal, this study selected 80 SD rats of 8 weeks. The experiment groups were divided them into four groups, and assigned 20 rats to each group. Group I was a experimental control group; GroupII was a tDCS application group after MCAo; Group III was a MST application group after MCAo; Group IV was a tDCS and MST application group after MCAo. In each group, neurological function test measurement, motor behavior test, montoya stair task test, immunohistochemistric finding of GFAP expression finding were analyzed. In motor behavior test, the outcome of group I was significantly difference than the other group, especially from 14days. In montoya stair task test, the outcome of group I was significantly lower than the other group especially, group II were significantly different on 14days and group IV was most significantly difference than the other group. In immunohistochemistric finding, group II, III, IV were decrease GFAP expression on depend on time stream. These results throughout the MCAo due to focal ischemic brain injury rat model four weeks tDCS and MST was applied, when the neurobehavioural, upper extremity function and ability, histopathologic data suggest that sensorimotor function recovery and a positive influence on glial scar decrease and confirmed that.
Suk Bum Zoo,Yoo Rim Choi,Ki Cheol Sim,Mi Jung Kim,Wan Suk Choi,Ja Pung Koo,Suk Hee Lee,Sang Bin Lee 국제물리치료학회 2011 Journal of International Academy of Physical Ther Vol.2 No.1
The purpose of this study is to investigate and reveal the effects that the complex exercise training consisting of aerobic exercise and strength training(sit up, push up) that everyone can easily practice regardless of a time and a place in order to manage practically the physical strength of the aged affects the difference on their body composition and the change of physical fitness level. Looking into the change of body composition of an experimental group, the weight of 2.5kg was reduced after applying complex training for 12 weeks and the body fat mass of 2.65kg was reduced. Also, the abdominal fat of 0.13% was decreased and the muscle mass of 1.56kg was increased. For the change factors of physical fitness, cardiovascular endurance, muscular strength, muscular endurance, balance and flexibility excluding agility showed significant improvement after applying complex exercise training. The improvement of health fitness of the aged under this study was significantly effective to improve specified body functions which had been lowered by aging and insufficient physical activities. So, it is regarded that their health fitness is the important factor to improve the activity competence required for daily life and to lead healthy living by the improved activity competence. Henceforth, it needs to study more the complex composition of several sports, exercise intensity and the frequency based on the previous researches and studies. In addition, it needs to develop the complex exercise training in accordance with various characteristics such as a sex of the aged, an age, a physical fitness level, environment, a disease and the program in consideration of the efficacy and safety during training.
Sung Hoon Ryu,Kyung Ok Min,Ki Cheol Sim,Gi Do Kim,Gye Yeop Kim 국제물리치료학회 2013 Journal of International Academy of Physical Ther Vol.4 No.1
This study is intended to examine the tDCS and Morris Water maze training in Alzheimer’s disease(AD) rats on Tau protein expression. Experiment groups were divided into four groups and assigned 16 rats to each group. Group Ⅰ was a control group(AD induced by scopolamine); Group Ⅱ was a experimental control group(AD injured by scopolamine and treatment tacrine); Group Ⅲ was a group of tDCS application after AD injured by scopolamine; Group Ⅳ was a group of morris water maze training after AD injured by scopolamine. In cognition test, the outcome of group Ⅱ was significantly lower than the groups(p<.001). and group Ⅲ, Ⅳ were significantly low result at 14 days(p<.05). In histological finding, the experimental groups were destroy of micro vessels and finding of cell atropy and swelling. Group Ⅲ, Ⅳ were decreased in degeneration of liver and kidney cells. In immuno- histochemistric response of BDNF and tau protein in hippocampus, BDNF expression of Group Ⅱ was more increase than the other groups. and increase of BDNF expression was Ⅲ, Ⅳ were higher than group Ⅰ at 21 days. Tau protein expression of Group Ⅱ was more decrease than the other groups. and decrease of Tau protein expression was Ⅲ, Ⅳ were lower than group Ⅰ at 21 days. These result suggest that improved tDCS and morris water maze training after scopolamine induced is associated with dynamically altered expression of BDNF and Tau protein in hippocampus and that is related with cognitive function.
Gi Do Kim,Kyung Ok Min,Kyung Yoon Kim,Ki Cheol Sim,Ki Won Nam,Ja Pung Koo,Joo Hyun Park,Ok Kon Moon,Seong Hun Yu,Gye Yeop Kim 국제물리치료학회 2010 Journal of International Academy of Physical Ther Vol.1 No.2
This study is intended to examine the motor skill learning and treadmill exercise on motor performance and synaptic plasticity in the cerebellar injured rats by harmaline. Experiment groups were divided into four groups and assigned 15 rats to each group. GroupⅠ was a normal control group(induced by saline); GroupⅡ was a experimental control group(cerebellar injured by harmaline); GroupⅢ was a group of motor skill learning after cerebellar injured by harmaline; GroupⅣ was a group of treadmill exercise after cerebellar injured by harmaline. In motor performance test, the outcome of groupⅡ was significantly lower than the groupⅢ, Ⅳ(especially groupⅢ)(p<.001). In histological finding, the experimental groups were destroy of dendrities and nucleus of cerebellar neurons. GroupⅢ, Ⅳ were decreased in degeneration of cerebellar neurons(especially groupⅢ). In immunohistochemistric response of synaptophysin in cerebellar cortex, experimental groups were decreased than groupⅠ. GroupⅢ's expression of synaptophysin was more increased than groupⅡ, Ⅳ. In electron microscopy finding, the experimental groups were degenerated of Purkinje cell. These result suggest that improved motor performance by motor skill learning after harmaline induced is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity.