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경상남도(慶尙南道) 밀양군(密陽郡) 삼랑진읍(三浪津邑)에 있어서의 간흡충(肝吸?) 감염실태조사(感染實態調査)
임한종,주경환,엄기선,박수배,Rim, Han-Jong,Joo, Kyoung-Hwan,Eom, Kee-Seon,Park, Soo-Bae 한국농촌의학지역보건학회 1982 농촌의학·지역보건 Vol.7 No.1
In order to observe the endemic status of Clonrchis sinensis infection in Samrangjin eup, Milyang gun, Kyongsang nam do, a total number of 294 stool specimens were collected from the inhabitants who lived in the basin of the Nakdong river. The specimens were examined by cellophane thick smear technique and Stoll's egg dilution technique during the period from May to June 1983. The epidemiological status was analysed statistically by the regression equation and catalytic curv with the results obtained from this area. The results are as follows : 1) The infestation rate of Clonorchis sinensis in 294 was 49.0%. 2) No remarkable difference was observed between male (52.5%) and female (44.8%). 3) Average E.P.G. by Stoll's egg dilution technique in this area was 9,597. 4) The degree of the intensity of Clonorchis infection by E.P.G. count was distributed as 10.5% in very heavy infection, 14.7% in heavy infection, 47.4% in moderate infection, and 29.3% in light infection. 5) The intensity of endemicity in this area was represented with the regression equation calculated with the cumulative percentages of E.P.G. counts. Regression equation was y=3.40+1.23 log x and Cs. $D._{50}$ was 19.99. 6) The two stage catalytic model was applied and the calculation lead to the equation $y=1296(e^{-0.008t}-e^{-0.035t})$ ; a=0.035 > b=0.008 in this surveyed area. 7) Other helminthic infection rate in this area was 7.1% in A. lumbricoides, 9.5% in T. trichiura and 4.1% in E. vermicularis respectively.
肝吸蟲症 治療前後에 있어서 血淸 및 尿의 抗體價變動에 관한 比較硏究
金亨東,嚴基善,林漢鍾 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3
The changes of IgG levels of sera and urine were observed with the enzyme-linked immunosorbent assay (ELISA) at before and after medication in human clonorchiasis. Sera and urine from 68 cases of confirmed clonorchiasis were tested at before and at 9 and 18 month after treatment with Distocide® (praziquantel). Group I (n=22) was cured after first medication and then followed up for 18 months. And Group Ⅲ (n=24) of patients with eggs in their feces after first medication showed egg reduction rate of 90%. Thirteen normal controls were parasite free healthy persons for clonorchiasis in non-endemic area. The antigen used was saline extract of crude Clonorchis sinensis adult worm with the protein concentration of 14.3㎍/㎖ and the results obtained were as follows: 1. When a serum dilution of 1:400 was used, the absorbance values (488 nm) were 1.122, 1.373 and 1.632 in groups Ⅰ,Ⅱ,Ⅲ respectively before medication. Antibody level decreased significantly at 9 months after medication showed 0.572, 0.749 and 1.155 in the respective group. Then the levels decreased slightly to 0.464, 0.516 and 1.107 at 18 months after medication. But the control group showed relatively constant absorbance values of 0.291 at before 0.301 and 0.286 respecively at 6 and 18 months. 2. Urine showed absorbance values of 0.484, 0.629 and 0.849 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. Then the values decreased about a half level revealed 0.261, 0.226 and 0.467 in the respective group at 18 months after medication. Control group showed relatively constant absorbance values 0.232 at before and 0.252 at 18 months. 3. The diameter of wheal size (mm) by intradermal test did not show substantial changes, i.e. 11.7, 13.3 and 12.7 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication; 11.7, 12.9, and 11.4 in the respective group at 18 months after medication. 4. The relation of the absorbance values between sera (y) and urine (x) made the regression equation: y=0.707X+0.908, and showed relatively high correlation (r=0.619, n=68, p<0.001) before medication; y=0.760X+0.387 with some correlation (r=0.582, n=68, p<0.001) at 18 months after medication. 5. The relation between the absorbance values of urine and log EPG (eggs per gram of feces)/100 revealed more or less irregular correlations, i.e.r=0.566(p<0.01), 0.661(p<0.001)and 0.384(p<0.10)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. 6. The relation between the absorbance values of urine and the wheal size (mm) by intradermal test showed low correlation, i,e, r=0.416(p<0.10), 0.416(p<0.10)and 0.421(p<0.05)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication.
간접형광항체반응에 의한 인체낭미충증의 혈청학적 진단에 관한 연구
강욱중,엄기선,임한종 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1
The indirect fluorescent antibody test (IFAT) for cysticercosis was accomplished with the sectioned cyst wall tissue antigen which was made with the cyst in the fourth ventricle of human brain. The antigen was revealed on the tegument, nuclear layer and internal surface of the bladder wall with FITC conjugated IgG fraction goat antihuman immunoglobulins. Total 236 sera were tested which were obtained from 24 cases of confirmed cerebral or dermal cysticercosis patients, 33 cases of suspected cysticercosis, 50 cases of intestinal or tissue invading larval cestodiasis, 50 cases of trematodiasis, 14 cases of nematodiasis or elevated eosinophilia and 65 cases of non-infected control sera. The serum titer of 1:16 or over was regarded as positive. Twenty three out of twenty four (95.8%) sera from confirmed cysticercosis patients were positive. Serum titer of 65 non-infected controls showed 1:8 or below. Twelve cases out of thirty three (36.4%) suspected cases of cysticercosis were revealed as positive. And cross reactions were observed in taeniasis solium (40.0%), taeniasis saginata (13.3%), diphyllobothridiasis laturn (11.8%) and lonorchiasis sinensis (2.8%). The mean titer of cerebral cysticercosis (7.60 in log₂) was higher than those of mixed (5.61 in log₂) and dermal cysticercosis (5.44 in log₂). The titers of cerebral cysticercosis patient's sera who were treated with praziquantel were not changed at least within six months in four cases out of seven followed up cases. In four to five year after treatment with praziquantel it showed decreased or negatively converted serum titers. Conclusively, it was indicated that indirect fluorescent antibody test using the sectioned antigen of Taenia solium cysticerci was applicable to the diagnosis of cysticercosis.
Capillaria hepatica 感染白鼠에 있어서 蟲卵抗原을 이용한 免疫診斷에 관한 比較硏究
鄭然郁,嚴基善,林漢鍾 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.3
Comparative studies were performed for Capillaric hepatica antibodies with following immunodiagnostic assays : circumoval precipitation reaction(COP) with lyophilized eggs as antigen, indirect fluorescent antibody test (IFAT) with sectioned egg antigen, enzyme-linked immunosorbent assay(ELISA) with soluble egg antigen and counterimmunoelectrophoresis (CIEP) with soluble egg antigen. In the first part of this study it was found that every type of egg antigens used were effective and showed almost equal sensitivities with proper immunodiagnostic methods. Additionally, antibodies to C. hepatica were detectable only during short period after experimental infection of embryonated eggs. Sera from 40 white rats infected with 2,000 eggs orally were collected randomly between three and nine weeks after infection and the infection with C. hepatica was identified by necropsy. COP, ELISA & CIEP had diagnostic sensitivities of 85.0% and IFAT, 82.5 %. Sera from 5 white rats infected with 2,000 eggs were collected periodically to observe the changing patterns of antibody titers by IFAT and ELISA, which showed that high titers were detected at weeks 3 and 5, then gradually declined through weeks 9 until to negatively converted at weeks 13. The immunodiagnostic method of choice was recommended as ELISA since the antibodies were detectable with lowest protein contents(1.25 ㎍/ml) of antigen and highest dilution of sera (1 : 3,000), even though the equal sensitivity with other methods by different antigen and antibody conditions.
肝吸蟲症에 있어서 血淸 및 濾紙吸着血淸을 이용한 酵素免疫測定法 (ELISA)에 관한 比較硏究
韓柱煥,嚴基善,林漢鍾 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1
To observe the usefulness of minute amount of blood obtained by the filter paper technique for serodiagnosis of clonorchiasis sinensis, a study was performed with the subjected cases of 142 egg positive cases and O negative controls by the immunodiagnostic method of ELISA. The absorbance values using the filter paper by ELISA were compared with the absorbance values using sera, and also with the E.P.G.(eggs per gram of feces) and the diameter of wheal size by intradermal test. The antigen used was saline extract of crude Clonorchis sinensis adult worm with the protein concentration of 11.3㎍/ml. The positive threshold of the absorbance value was 0.5 at 488nm. The results obtained were as follows: 1. Comparing the sensitivity and the specificity between the filter paper technique and the method using sera by ELISA, 121 out of 140 egg positive cases were positive(sensitivity, 88.4%) and 69 out of 70 controls were negative(specificity, 98. 6%) when the blood collected on the filter paper were used; and 132 out of 140 egg positive cases were positive (sensitivity, 93.0%) and 67 out of 70 control were negative(specificity, 95.7%) when sera were used. Thus the specificity by the filter paper method was similar to that by the sera although the sensitivity was lower. 2. The relation of the absorbance values between the blood collected on the filter paper (y-axis) and sera(x-axis) made the regression equation: y=0. 473x+0.248, and showed relatively high correlation (r=0. 739, n=210, p<0. 01). 3. The relation of the absorbance values between the blood collected on the filter paper (y-axis) and the number of eggs(Log E.P.G./100) made the regression equation: y=0. 254 x+0.654, and showed some correlation(r=O. 541, n=140, p<0.01). And the mean absorbance values of the four classified groups were increased gradually with the intensity of the infection by E.P.G.: light infection with 1~999 E.P.G., moderate infection with 1,000-9,999 E.P.G., heavy infection with 10,000~.29,999 E.P.G. and very heavy infection with the E.P.G. of 30,000 or over. 4. The relation of the absorbance values between the blood collected on the filter paper (x-axis) and the diameter of the wheal by intradermal test(y-axis) made the regression equation : y=0. 087x+1.169, and showed low correlation (r=o. 192, n=140, p<0.01). 5. The absorbance values of the blood collected on the filter paper and those of sera and the diameter of wheal by intradermal test of the egg positive cases were age-independent. This study showed that the blood collected on the filter Gaper technique was applicable for the diagnosis of clonorchiasis by the method of ELISA.