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Min Zhou,Jie Lou,Yin-Ke Li,Yue-De Wang,Kun Zhou,Bing-Kun Ji,Wei Dong,Xue-Mei Gao,Gang Du,Qiu-Fen Hu 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1
Versicolols A and B (1 and 2), two rareprenylated isocoumarin derivatives, along with five knownisocoumarins (3–7) were isolated from the fermentationproducts of an endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensivespectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicityagainst five human tumor cell lines. The resultsshowed that compounds 1 exhibited weak cytotoxicityagainst A549 and MCF7 cells with IC50 values of 9.4 and8.8 lm, and compound 2 exhibited weak cytotoxicityagainst SHSY5Y and MCF7 cells with IC50 values of 8.2and 6.8 lm, respectively.
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Exergy analysis of a frost-free air source heat pump system
Zhihua Wang,Fenghao Wang,Xiuzhi Gao,Ke Li,Yechun Lou 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.5
The main focus of this paper is to analyze the exergetic characteristics of a frost-free air source heat pump (ASHP) integrated with solid dehumidification and phase change heat storage. The exergy loss, exergy loss ratio and exergy efficiency of the system have been calculated to investigate the influence of the operation modes on the system characteristics. In addition, a comprehensive exergy loss ratio is defined to evaluate the system performance. It is concluded that the comprehensive highest exergy loss ratio is obtained as 51.4 % for compressor, followed by the energy storage device (ESD) with 15.8 %, the extra heat exchanger coated with a solid desiccant (EHECSD) with 10.7 %. Also the variation of the exergy loss, exergy loss ratio and exergy efficiency of the system and the key components with the ambient temperature changes from -20 to 5 °C are discussed. This study can provide guidance for optimizing the structure and improving the frost-free ASHP system in the engineering applications.
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Ming Jiang,Yunfei Li,Yuan Ge,Wengeng Gao,Ke Lou,Shinong Wang,Juanjuan Jiang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.12
Position information is the foundation of massive applications in Wireless Sensor Network(WSN). Three improved positioning algorithms based on DV-Hop are proposed in order to enhance the positioning accuracy of wireless sensor nodes. First improved algorithm is distance compensation algorithm (DCA) that creates a triangle model to compensate the estimated distance. The second improved algorithm creates a new chain table for all anchor nodes to record and compute the average hop distance. The third improved algorithm is weighting different anchor nodes with anchor nodes’ nearest unknown nodes. The second and third improved algorithms are based on the DCA. The simulation results show that the three improved algorithms are better than the original DV-Hop in localization accuracy. Compared to the original DV-Hop algorithm, the simulation results shows that the three improved algorithms proposed in the paper increase the positioning accuracy of the unknown nodes.
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Li, Xiao-Fei,He, Hua-Bin,Zhu, Yan-Shuang,He, Jin-Ke,Ye, Wei-Wei,Chen, Yong-Xin,Lou, Lian-Qing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
The objective of this study was to evaluate the influence of a genetic variant in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma (HCC) risk. This case-control study was conducted in a Chinese population of 645 HCC cases and 658 cancer-free controls. The genotype of the c.3751G>A genetic variant in the MDR1 gene was investigated by created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods. Our data demonstrated significantly differences detected in the allelic and genotypic frequencies between HCC cases and those of cancer-free controls. Association analyses indicated that there were statistically increased risk of HCC in the homozygote comparison (AA versus (vs.) GG: OR=2.22, 95% CI 1.51-3.27, ${\chi}^2$=16.90, P<0.001), dominant model (AA/GA vs. GG: OR=1.25, 95% CI 1.00-1.55, ${\chi}^2$=3.98, P=0.046), recessive model (AA vs. GA/GG: OR=2.14, 95% CI 1.47-3.09, ${\chi}^2$=16.68, P<0.001) and allele comparison (A vs. G: OR=1.33, 95% CI 1.13-1.57, ${\chi}^2$=11.66, P=0.001). The allele-A and genotype-AA may contribute to HCC susceptibility. These preliminary findings suggest that the c.3751G>A genetic variant in the MDR1 gene is potentially related to HCC susceptibility in a Chinese Han population, and might be used as a molecular marker for evaluating HCC susceptibility.
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Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis
Ruixi Luo,Weiyi Tian,Yudie Hu,La Wang,Wenjia Wang,Ping Wang,Zunli Ke,Didong Lou 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
It is currently thought that excess fatty acid-induced lipotoxicity in hepatocytes is a critical initiator in thedevelopment of nonalcoholic fatty liver disease (NAFLD). Lipotoxicity can induce hepatocyte death; thus, reducing lipotoxicityis one of the most effective therapeutic methods to combat NAFLD. Abundant evidence has shown that hesperidin(HSP), a type of flavanone mainly found in citrus fruits, is able to ameliorate NAFLD, but the molecular mechanisms areunclear. We previously reported that pyroptosis contributed to NAFLD development and that inhibiting pyroptosis contributedto blunting the progression of NAFLD in rat models. Therefore, we questioned whether HSP could contribute to amelioratingNAFLD by modulating pyroptosis. In this study, a high-fat diet (HFD) induced dyslipidemia and hepatic lipotoxicity in rats,and HSP supplementation ameliorated dyslipidemia and insulin resistance. In addition, the HFD also caused pyroptosis in theliver and pancreas, while HSP supplementation ameliorated pyroptosis. In vitro, we found that HSP ameliorated palmitic acidinducedlipotoxicity and pyroptosis in HepG2 and INS-1E cells. In conclusion, we showed for the first time that HSP has aprotective effect against liver and pancreas damage in terms of pyroptosis and provides a novel mechanism for the protectiveeffects of HSP on NAFLD.
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