Composition of Optimized Assessment Sheet with Multi-criteria using Evolutionary IntelligentWater Drops (EvIWD) Algorithm

Kavitha 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.6

At the present time, computerized tests are one of the most critical means to evaluate learning. Choosing tailored questions for each learner is a important part of such tests. Since, wide and varied learners with different abilities are involved, even randomized test cannot serve the purpose of assessment. Some form of personalized and intelligent testing is needed in E-Learning. One of the main components in composing intelligent testing is selecting the items from a huge Item Bank as the accuracy of the test depends on the quality of the assessment which in turn depends on the items selected for assessment. Furthermore, pickingappropriate items is critical in developing as assessment sheet that satisfies multiple criteria. It includes the number of test items, the definitedissemination of course concepts to be assessed, and the expected degree of difficultness and discrimination and exposure frequency. These tests, must effectively select questions from a large item bank, and to manage this problem an optimized assessment sheet composition system using the modified form of nature inspired Intelligent Water Drops optimization algorithm is proposed by embedding a local heuristic as evolutionary operator. This system is designed to choosepersonalizedtest items for each and every learner. Furthermore, the proposed approach is able to effectively generate near optimal items from large item bank that satisfy multiple constraints. The results show that the Evolutionary Intelligent Water Drops approach is suitable for the selection of nearoptimal items from large-scale item bank.

Oral Presentations : Nutritional Assessment ; Nutritional Evaluation of Cancer Patients

( Kavitha Menon ),( Shariza Abdul Razak ),( Murali Krishna B. V. ),( Rusmin S. A. ),( Ahmed K. I. ) 한국정맥경장영양학회 2005 The 11th PENSA Congress Vol.2005 No.-

The combination of a histogram-based clustering algorithm and support vector machine for the diagnosis of osteoporosis

Kavitha, Muthu Subash,Asano, Akira,Taguchi, Akira,Heo, Min-Suk Korean Academy of Oral and Maxillofacial Radiology 2013 Imaging Science in Dentistry Vol.43 No.3

Purpose: To prevent low bone mineral density (BMD), that is, osteoporosis, in postmenopausal women, it is essential to diagnose osteoporosis more precisely. This study presented an automatic approach utilizing a histogram-based automatic clustering (HAC) algorithm with a support vector machine (SVM) to analyse dental panoramic radiographs (DPRs) and thus improve diagnostic accuracy by identifying postmenopausal women with low BMD or osteoporosis. Materials and Methods: We integrated our newly-proposed histogram-based automatic clustering (HAC) algorithm with our previously-designed computer-aided diagnosis system. The extracted moment-based features (mean, variance, skewness, and kurtosis) of the mandibular cortical width for the radial basis function (RBF) SVM classifier were employed. We also compared the diagnostic efficacy of the SVM model with the back propagation (BP) neural network model. In this study, DPRs and BMD measurements of 100 postmenopausal women patients (aged >50 years), with no previous record of osteoporosis, were randomly selected for inclusion. Results: The accuracy, sensitivity, and specificity of the BMD measurements using our HAC-SVM model to identify women with low BMD were 93.0% (88.0%-98.0%), 95.8% (91.9%-99.7%) and 86.6% (79.9%-93.3%), respectively, at the lumbar spine; and 89.0% (82.9%-95.1%), 96.0% (92.2%-99.8%) and 84.0% (76.8%-91.2%), respectively, at the femoral neck. Conclusion: Our experimental results predict that the proposed HAC-SVM model combination applied on DPRs could be useful to assist dentists in early diagnosis and help to reduce the morbidity and mortality associated with low BMD and osteoporosis.

Reconfigurable Selective Harmonic Elimination Technique for Wide Range Operations in Asymmetric Cascaded Multilevel Inverter

Kavitha R,Rani Thottungal 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.4

This paper presents a novel reconfigurable selective harmonic elimination technique to control harmonics over a wide range of Modulation Indexes (MI) in Multi-Level Inverter (MLI). In the proposed method, the region of the MI is divided into various sectors and expressions are formulated with different switching patterns for each of the sectors. A memetic BBO-MAS (Biogeography Based Optimization - Mesh Adaptive direct Search) optimization algorithm is proposed for solving the Selective Harmonic Elimination - Pulse Width Modulation (SHE-PWM) technique. An experimental prototype is developed using a Field Programmable Gate Array (FPGA) and their FFT spectrums are analyzed over a wide range of MI using a fluke power logger. Simulation and experimental results have validated the performance of the proposed optimization algorithms and the reconfigurable SHE-PWM technique. Further, the sensitivity of the harmonics has been analyzed considering non-integer variations in the magnitude of the input DC sources.

Correlation between EGFR Gene Mutations and Lung Cancer: a Hospital-Based Study

Kavitha, Matam,Iravathy, Goud,Adi Maha, Lakshmi M,Ravi, V,Sridhar, K,Vijayanand, Reddy P,Chakravarthy, Srinivas,Prasad, SVSS,Tabassum, Shaik Nazia,Shaik, Noor Ahmad,Syed, Rabbani,Alharbi, Khalid Khala Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including lung malignancies. Gefitinib and erlotinib are two available therapeutics that act as specific inhibitors of tyrosine kinase (TK) domains. We performed a case-control study with formalin-fixed paraffin-embedded tissue blocks (FFPE) from tissue biopsies of 167 non-small cell lung carcinoma (NSCLC) patients and 167 healthy controls. The tissue biopsies were studied for mutations in exons 18-21 of the EGFR gene. This study was performed using PCR followed by DNA sequencing. We identified 63 mutations in 33 men and 30 women. Mutations were detected in exon 19 (delE746-A750, delE746-T751, delL747-E749, delL747-P753, delL747-T751) in 32 patients, exon 20 (S786I, T790M) in 16, and exon 21 (L858R) in 15. No mutations were observed in exon 18. The 63 patients with EFGR mutations were considered for upfront therapy with oral tyrosine kinase inhibitor (TKI) drugs and have responded well to therapy over the last 15 months. The control patients had no mutations in any of the exons studied. The advent of EGFR TKI therapy has provided a powerful new treatment modality for patients diagnosed with NSCLC. The study emphasizes the frequency of EGFR mutations in NSCLC patients and its role as an important predictive marker for response to oral TKI in the south Indian population.

Poly(acrylic acid)-Grafted Graphene Oxide as an Intracellular Protein Carrier

Kavitha, Thangavelu,Kang, Inn-Kyu,Park, Soo-Young American Chemical Society 2014 Langmuir Vol.30 No.1

<P>A pH-sensitive poly(acrylic acid)-grafted graphene oxide (GO-PAA) nanocarrier was synthesized by in situ atom transfer radical polymerization to allow the oral delivery of hydrophilic macromolecular proteins in their active forms to specific cells or organs. The synthesis, morphology, and physiochemical properties of GO-PAA were examined. A model protein, bovine serum albumin (BSA) labeled with fluorescein isothiocyanate (FITC) (BSAFITC), was loaded onto GO-PAA through noncovalent interactions and its release was arrested at acidic pH similar to stomach, whereas at pH similar to intestine it was reduced, which paves way for site specific delivery without its degradation in the gastrointestinal tract. Confocal laser microscopy showed that the BSAFITC-loaded GO-PAA was internalized by KB cells by endocytosis and released into cytoplasm. Thus the GO-PAA as a transmembrane transporter is a new class of drug transporters with potential protein delivery applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2014/langd5.2014.30.issue-1/la404337d/production/images/medium/la-2013-04337d_0012.gif'></P>

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

Kavitha, Nowroji,Vijayarathna, Soundararajan,Jothy, Subramanion Lachumy,Oon, Chern Ein,Chen, Yeng,Kanwar, Jagat Rakesh,Sasidharan, Sreenivasan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.

Enhancement of biogas production from microalgal biomass through cellulolytic bacterial pretreatment

Kavitha, S.,Subbulakshmi, P.,Rajesh Banu, J.,Gobi, Muthukaruppan,Tae Yeom, Ick Elsevier 2017 Bioresource technology Vol.233 No.-

<P><B>Abstract</B></P> <P>Generation of bioenergy from microalgal biomass has been a focus of interest in recent years. The recalcitrant nature of microalgal biomass owing to its high cellulose content limits methane generation. Thus, the present study investigates the effect of bacterial-based biological pretreatment on liquefaction of the microalga <I>Chlorella vulgaris</I> prior to anaerobic biodegradation to gain insights into energy efficient biomethanation. Liquefaction of microalgae resulted in a higher biomass stress index of about 18% in the experimental (pretreated with cellulose-secreting bacteria) vs. 11.8% in the control (non-pretreated) group. Mathematical modelling of the biomethanation studies implied that bacterial pretreatment had a greater influence on sustainable methane recovery, with a methane yield of about 0.08 (g Chemical Oxygen Demand/g Chemical Oxygen Demand), than did control pretreatment, with a yield of 0.04 (g Chemical Oxygen Demand/g Chemical Oxygen Demand). Energetic analysis of the proposed method of pretreatment showed a positive energy ratio of 1.04.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Microalgal biomass pretreatment by bacteria enhances liquefaction of about 18%. </LI> <LI> Bacterial pretreatment increases the macromolecular release considerably. </LI> <LI> Experimental microalgae improves the methane to 0.08gCOD/gCOD comparing to control. </LI> <LI> Methane production rate increased with hydrolysis constant of about 0.24day<SUP>−1</SUP>. </LI> <LI> A positive energy ratio of about 1.04 was achieved in experimental microalgae. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

In vitro Plant Regeneration from Apical Bud and Nodal Segments of Anthocepahalus Cadamba - An important sacred and medicinal tree

Kavitha, M.,Kalaimagal, I.,Mercy, S.,Sangeetha, N.,Ganesh, D. Institute of Forest Science 2009 Journal of Forest Science Vol.25 No.2

Multiple shoot induction and plant regeneration using apical bud and nodal explants of 100 year old tree of Anthocephalus cadamba, an important sacred and medicinal tree in India was achieved for the first time. Aseptic explants cultured in Murashige and Skoog (MS) medium augmented with different concentrations of BAP (0.1, 0.5, 1.0, 2.5, 5.0 and 10 mg/l), when maintained for 60 days, healthy shoots were induced in presence of BAP (1 mg/l). Lower concentrations of BAP (0.1 - 0.5 mg/l) induced only one shoot per explant. Increase in number of shoots per explant was observed in presence of higher concentrations of BAP (2.5, 5.0 and 10 mg/l). However, elongation of shoots was completely inhibited. Bud break and shoot regeneration was largely associated with seasonal factors. Apical buds cultured during June to August exhibited early bud break within two weeks of initial culture. In rest of the months, bud break and shoot regeneration was very slow irrespective of the various concentrations of BAP used in the medium. Explants sourced from three different maturity levels of shoots indicated that actively growing shoots from the mother plant with 1 - 2 nodal segments was more suitable for culture initiation than the explants collected from mature shoots at dormant stage. Regenerated shoots with 2 - 3 pairs of leaves when transferred to half strength MS medium fortified with IBA (1 mg/l), 60% of the shoots induced healthy roots, indicating the possibility of large scale micropropagation.

Resonant Parametric Perturbation Method to Control Chaos in Current Mode Controlled DC-DC Buck-Boost Converter

Kavitha, Anbukumar,Uma, Govindarajan The Korean Institute of Electrical Engineers 2010 Journal of Electrical Engineering & Technology Vol.5 No.1

Resonant parametric perturbation (RPP) method is an effective non-feedback method for controlling chaos. In this paper, the above method is applied for the current programmed buck-boost dc-dc converter which exhibits chaotic for wide parameter variations. The different possible operating regimes leading to chaotic operation of the current mode controlled buck-boost converter is discussed and the control of chaos by RPP method is demonstrated through computer simulations and experimental studies. The converter is stabilized to period 1 operation practically.