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- 저자 : Kaiying Wang (검색결과 3 건)
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Wang Shumin,Dong Kaiye,Zhang Ji,Chen Chaochao,Shuai Hongyan,Yu Xin 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.6
BACKGROUND/OBJECTIVES: Inonotus obliquus has been used as antidiabetic herb around the world, especially in the Russian and Scandinavian countries. Diabetes is widely believed to be a key factor in Alzheimer’s disease (AD), which is widely considered to be type III diabetes. To investigate whether I. obliquus can also ameliorate AD, it would be interesting to identify new clues for AD treatment. We tested the anti-AD effects of raw Inonotus obliquus polysaccharide (IOP) in a mouse model of AD (3×Tg-AD transgenic mice). MATERIALS/METHODS: SPF-grade 3×Tg-AD mice were randomly divided into three groups (Control, Metformin, and raw IOP groups, n = 5 per group). β-Amyloid deposition in the brain was analyzed using immunohistochemistry for AD characterization. Gene and protein expression of pertinent factors of the ubiquitin-proteasome system (UPS) was determined using real-time quantitative polymerase chain reaction and Western blotting. RESULTS: Raw IOP significantly reduced the accumulation of amyloid aggregates and facilitated UPS activity, resulting in a significant reduction in AD-related symptoms in an AD mouse model. The presence of raw IOP significantly enhanced the expression of ubiquitin, E1, and Parkin (E3) at both the mRNA and protein levels in the mouse hippocampus. The mRNA level of ubiquitin carboxyl-terminal hydrolase isozyme L1, a key factor involved in UPS activation, also increased by approximately 50%. CONCLUSIONS: Raw IOP could contribute to AD amelioration via the UPS pathway, which could be considered as a new potential strategy for AD treatment, although we could not exclude other mechanisms involved in counteracting AD processing.
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Yongzhi Wang,Mengbo Liu,Shaoming Liao,Qiong Yi,Junzuo He,Linqi Liu,Zhiqun Gong,Kaiying Li 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5
Press-in open caisson method, which sinks into soil with the aid of mechanical pressure without excavation, is becoming an important method of construction in extremely soft foundations. However, many engineering problems are prone to occur in the construction of caissons, such as sinking and large deformation. In this study, the stratigraphic response model, such as soil migration during the press-in process of open caisson, is focused on. Through model tests of soil and caissons, the migration patterns of each part of the soil were carried out, and the mechanism underlying the stratigraphic response pattern was investigated. The three primary conclusions are as follows: 1) The bottom edge foot of caisson produces lateral extrusion on surrounding soil in the range of 10 cm (20%H) below, resulting in lateral movement of soil. 2) two kinds of plug, i.e., “wedged” and “unwedged” plugs exist, and the driven forces for the soil migration can be divided into three stages, i.e., caused by soil plug with active arch, by soil plug with passive arch and caused by soil squeezing effect. 3) there is a significant linear correlation between the soil plug changes, the horizontal movement of the deep soil body, and the displacement of the surface uplift. The soil plugging effect and squeezing effect are interacted and enhanced with each other. This study provides a new understanding of the stratigraphic response in the construction of press-in open caissons, andguides safety control of open caissons construction.
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Influence of oxygen vacancies on the EPIR effect in Nd0.7Sr0.3MnO3 ceramics
Dawei Shi,Shunsheng Chen,Di Liu,Lingfang Xu,Haibo Xiao,Changping Yang,Kaiying Wang 한국물리학회 2015 Current Applied Physics Vol.15 No.8
Nd0.7Sr0.3MnO3 polycrystalline ceramic samples (NSMO) were synthesized by solid state reaction with a post annealing for parts of samples under different partial pressures of oxygen at 1350 ℃ for 12 h. XRD shows that all the samples are in single phase with a perovskite structure. The electrical transport measurement implies that the oxygen concentration has an important influence on the electrical pulse induced resistance, i.e. the EPIR-effect, for NSMO samples. For the oxygen-enriched sample, which probably contains a smaller amount of oxygen vacancies, the I-V characteristic is linear with a very small resistance, and the EPIR-effect is not detectable within the experimental accuracy. However, after sintered and annealed in reducing atmospheres, an EPIR effect appears and even becomes stronger and more stable if the sintering atmosphere is more reducing than that of normal air condition. Besides, the I -V becomes nonlinear and the initial resistance increases with increasing deficiency of oxygen, which means that the oxygen vacancies and their deep level trap states play an important role for the EPIR effect of NSMO. In this manuscript, an oxygen vacancy trapped state model is put forward to explain the relation between oxygen concentration and the EPIR effect.
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