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Kim, Hyuk Soon,Kim, A-Ram,Kim, Do Kyun,Kim, Hyun Woo,Park, Young Hwan,Jang, Geun Hyo,Kim, Bokyung,Park, Yeong Min,You, Jueng Soo,Kim, Hyung Sik,Beaven, Michael A.,Kim, Young Mi,Choi, Wahn Soo AAAS 2015 Science signaling Vol.8 No.368
<P>Subsets of B cells inhibit various immune responses through their production of the cytokine interleukin-10 (IL-10). We found that IL-10-producing CD5(+) B cells suppressed the immunoglobulin E (IgE)- and antigen-mediated activation of mast cells in vitro as well as allergic responses in mice in an IL-10-dependent manner. Furthermore, the suppressive effect of these B cells on mast cells in vitro and in vivo depended on direct cell-to-cell contact through the costimulatory receptor CD40 on CD5(+) B cells and the CD40 ligand on mast cells. This contact enhanced the production of IL-10 by the CD5(+) B cells. Through activation of the Janus-activated kinase-signal transducer and activator of transcription 3 pathway, IL-10 decreased the abundance of the kinases Fyn and Fgr and inhibited the activation of the downstream kinase Syk in mast cells. Together, these findings suggest that an important function of IL-10-producing CD5(+) B cells is inhibiting mast cells and IgE-mediated allergic responses.</P>
Kim, Bokyung,Ji, Kyunghee,Kho, Younglim,Kim, Pan-Gyi,Park, Kyunghwa,Kim, Kyungtae,Kim, Youngsuk,Kim, Ki-Tae,Choi, Kyungho Pergamon Press 2017 Chemosphere Vol.185 No.-
<P><B>Abstract</B></P> <P>Cefadroxil and cefradine have frequently been detected in surface waters, however toxicological studies in aquatic organisms have mostly been limited to acute lethal effects. In the present study, endocrine disruption caused by cefadroxil and cefradine, and its underlying mechanism were investigated by chronic exposure of <I>Daphnia magna</I> (21 d) and <I>Oryzias latipes</I> (120 d). In medaka fish, the effects on growth, mortality, and reproduction, as well as on the levels of hormones and genes related to the hypothalamic-pituitary-gonad (HPG) axis, were investigated after 120 d exposure. In <I>D. magna</I>, the chronic effects on growth were observed at the highest concentration of 83.0 mg L<SUP>−1</SUP> cefadroxil and 80.8 mg L<SUP>−1</SUP> cefradine. The growth of juvenile fish was significantly impaired by exposure to cefradine. Following exposure to cefadroxil and cefradine for 120 d, sex-dependent changes in E2 hormones were observed and their levels were supported by the regulation of genes along the HPG axis. We found that chronic exposure to cefadroxil and cefradine impaired growth and reproduction in a freshwater invertebrate and fish, and altered the levels of sex hormones and genes associated with the HPG axis in fish.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cefadroxil and cefradine impaired growth in a freshwater invertebrate and a fish. </LI> <LI> Cephalosporin antibiotics altered gene transcriptions of the HPG axis in fish. </LI> <LI> Cefadroxil and cefradine modulated sex hormones and genes in a sex-dependent way. </LI> </UL> </P>
The Scaffold Protein Prohibitin Is Required for Antigen-Stimulated Signaling in Mast Cells
Kim, Do Kyun,Kim, Hyuk Soon,Kim, A-Ram,Jang, Geun Hyo,Kim, Hyun Woo,Park, Young Hwan,Kim, Bokyung,Park, Yeong Min,Beaven, Michael A.,Kim, Young Mi,Choi, Wahn Soo AAAS 2013 Science signaling Vol.6 No.292
<P><B>How to Prohibit Mast Cell Activation</B></P><P>Mast cells are the major effector cells of the allergic response. Binding of antigen to immunoglobulin E (IgE) molecules bound to the cell-surface, high-affinity IgE receptor FcεRI results in receptor clustering, mast cell activation, and degranulation, resulting in the release of factors that mediate the allergic response. Phosphorylation and activation of the Src family kinases Lyn and Syk are critical for mast cell activation. Kim <I>et al</I>. found that the scaffold protein prohibitin (PHB), which mediates functions such as mitochondrial biogenesis and transcriptional regulation (see commentary by Yurugi and Rajalingam), was abundant in intracellular granules in mouse mast cells. Stimulation of mast cells with antigen resulted in the translocation of PHB to plasma membrane lipid rafts, which was required for the association of FcεRI with Syk, the activation of Syk, and degranulation. Knockdown of PHB in mice inhibited mast cell activation and anaphylaxis, suggesting that targeting PHB therapeutically may reduce allergic responses.</P>
KIM, JIN-AH,KIM, DONG HWAN,HOSSAIN, MOHAMMAD AKBAR,KIM, MIN YOUNG,SUNG, BOKYUNG,YOON, JEONG-HYUN,SUH, HONGSUK,JEONG, TAE CHEON,CHUNG, HAE YOUNG,KIM, NAM DEUK Spandidos Publications 2014 International journal of oncology Vol.44 No.2
Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of cells. Of note, HS-1793 induced p53/p21(WAF1/CIP1)-dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells. Thus, these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer.
Kim, Soojin,Jeong, Jaewon,Jung, Hye-Seon,Kim, Bokyung,Kim, Ye-Eun,Lim, Da-Sol,Kim, So-Dam,Song, Yun Seon The Korean Society for Brain and Neural Science 2017 Experimental Neurobiology Vol.26 No.4
<P>Glucagon like peptide-1 (GLP-1) stimulates glucose-dependent insulin secretion. Dipeptidyl peptidase-4 (DPP-4) inhibitors, which block inactivation of GLP-1, are currently in clinical use for type 2 diabetes mellitus. Recently, GLP-1 has also been reported to have neuroprotective effects in cases of cerebral ischemia. We therefore investigated the neuroprotective effects of GLP-1 receptor (GLP-1R) agonist, exendin-4 (ex-4), after cerebral ischemia-reperfusion injury. Transient middle cerebral artery occlusion (tMCAO) was induced in rats by intracerebroventricular (i.c.v.) administration of ex-4 or ex9-39. Oxygen-glucose deprivation was also induced in primary neurons, bEnd.3 cells, and BV-2. Ischemia-reperfusion injury reduced expression of GLP-1R. Additionally, higher oxidative stress in SOD2 KO mice decreased expression of GLP-1R. Downregulation of GLP-1R by ischemic injury was 70% restored by GLP-1R agonist, ex-4, which resulted in significant reduction of infarct volume. Levels of intracellular cyclic AMP, a second messenger of GLP-1R, were also increased by 2.7-fold as a result of high GLP-1R expression. Moreover, our results showed that ex-4 attenuated pro-inflammatory cyclooxygenase-2 (COX-2) and prostaglandin E<SUB>2</SUB> after MCAO. C-Jun NH<SUB>2</SUB> terminal kinase (JNK) signaling, which stimulates activation of COX-2, was 36% inhibited by i.c.v. injection of ex-4 at 24 h. Islet-brain 1 (IB1), a scaffold regulator of JNK, was 1.7-fold increased by ex-4. GLP-1R activation by ex-4 resulted in reduction of COX-2 through increasing IB1 expression, resulting in anti-inflammatory neuroprotection during stroke. Our study suggests that the anti-inflammatory action of GLP-1 could be used as a new strategy for the treatment of neuroinflammation after stroke accompanied by hyperglycemia.</P>
Development of chicken stock improved protein content and antioxidant activity
Bokyung Kim,Mi-Hwa Park,Seungcheol Lim,Inkyung Kim,Mihyang Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study aimed to develop a chicken stock and natural seasoning with improved protein content and antioxidant activity. The general components of chicken stock (CS) and chicken stock with apple (CSA) were analyzed. The sugar content (brix), salinity and pH of CS and CSA were not significantly different among the groups. However, CSA showed a significant increased in crude protein content compared to CS. We examined also the change in antioxidant activity by the pretreatment method of Lentinula edodes (LE) to be added to chicken stock. There were three types of pretreatment methods: raw, naturally dried, and roasted. The polyphenol content due to the difference in pretreatment method was not significant between raw and natural dried LE. However, the polyphenol content of LE by the roasting method was higher than that of the raw and natural drying methods. DPPH and ABTS activities were also higher in LE dried by the roasting method than raw and naturally dried LE. Therefore, we decided to use roasted LE for development of chicken stock. The above results are expected to help improve the functionality of chicken stock and develop healthy products.