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Nakajima, K.,Yin, X.,Takei, Y.,Seog, D.H.,Homma, N.,Hirokawa, N. Cell Press 2012 Neuron Vol.76 No.5
KIF5 (also known as kinesin-1) family members, consisting of KIF5A, KIF5B, and KIF5C, are microtubule-dependent molecular motors that are important for neuronal function. Among the KIF5s, KIF5A is neuron specific and highly expressed in the central nervous system. However, the specific roles of KIF5A remain unknown. Here, we established conditional Kif5a-knockout mice in which KIF5A protein expression was postnatally suppressed in neurons. Epileptic phenotypes were observed by electroencephalogram abnormalities in knockout mice because of impaired GABA<SUB>A</SUB> receptor (GABA<SUB>A</SUB>R)-mediated synaptic transmission. We also identified reduced cell surface expression of GABA<SUB>A</SUB>R in knockout neurons. Importantly, we identified that KIF5A specifically interacted with GABA<SUB>A</SUB>R-associated protein (GABARAP) that is known to be involved in GABA<SUB>A</SUB>R trafficking. KIF5A regulated neuronal surface expression of GABA<SUB>A</SUB>Rs via an interaction with GABARAP. These results provide an insight into the molecular mechanisms of KIF5A, which regulate inhibitory neural transmission.
Y. Liu,S. Hashimoto,K. Yasumoto,K. Takei,M. Mori,Y. Funahashi,Y. Fijishiro,A. Hirano,Y. Takeda 한국물리학회 2009 Current Applied Physics Vol.9 No.11
The catalytic activity of the La0.6Sr0.4CoxFe1-xO3-δ (x = 0.2) perovskite cathode was significantly improved by introducing Ag. This strongly depends on the particle size of Ag that relates to the synthesis route. The Ag particles in nano-range were in situ incorporated into the La0.6Sr0.4Co0.2Fe0.8O3-δ based cathode using a novel infiltration. The functional cathode was successfully operated on the anode-supported cell with a ceria thin-electrolyte resulting in a higher cell output at 500 ℃. Durability of the cell was evaluated within a short-term period. The catalytic activity of the La0.6Sr0.4CoxFe1-xO3-δ (x = 0.2) perovskite cathode was significantly improved by introducing Ag. This strongly depends on the particle size of Ag that relates to the synthesis route. The Ag particles in nano-range were in situ incorporated into the La0.6Sr0.4Co0.2Fe0.8O3-δ based cathode using a novel infiltration. The functional cathode was successfully operated on the anode-supported cell with a ceria thin-electrolyte resulting in a higher cell output at 500 ℃. Durability of the cell was evaluated within a short-term period.
Flow Analysis around a Floating Cylinder in a Swirl Flow with a Stereoscopic-PIV
Doh D.H(도덕희),Hwang T.G(황태규),Tanaka K(다나카 코지),Takei M(타께이 마사) 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-
The flow characteristics around a floating cylinder in a swirling flow field in a vertical pipe with a length of 600㎜ and an inner diameter of 100mm is investigated by the use of the Stereoscopic-PIV system. The measurement system consists of two cameras, a Nd-Yag laser and a host computer. Optical sensors(LEDs) were used to detect the location of the floating cylinder and to activate the Stereoscopic-PIV system. A conditional sampling Stereoscopic-PIV system was developed in which the flow fields around the floating cylinder are measured at the events of the activations. It has been verified that the motion of the floating cylinder becomes stable when the azimuthal velocity component of the swirl flow is maintained at stable states.