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Inhibitory Activities of Rubi Fructus on Digestive Enzymes
Jung Sung Kim,Woo Jin Jeon,유현주,박명수,Geun Eog Ji 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.5
Control of postprandial glucose level is important in the management of diabetes. Thus, carbohydratehydrolyzing enzymes have been the targets to delay absorption of glucose. In this study, water extracts of Rubi Fructus (WERF) showed inhibition on both α-glucosidase from baker's yeast and α-amylase from porcine pancreas. The IC50 value of WERF on α-amylase was 59.4 μg/mL. The inhibitory activities of WERF were considerably decreased during incubation at 25, 37, and 45℃ for 24 hr. For the assessment of the active components tannin fraction was separated from WERF using Sephadex LH-20. Whereas LH-unbound fraction showed minimal inhibition on α-amylase LH-bound fraction containing enriched tannins showed higher inhibition (IC50 8.9 μg/mL) than WERF (IC50 59.4 μg/mL). These results suggested that tannin enriched fraction of WERF contributed to the inhibitory activity of WERF on α-amylase.
Direct-Current Treatment as a Safe Sterilization Method for Electrospun Biodegradable Polymer
HyeLeeKim,JeongHyunLee,MiHeeLee,HakHeeKim,JungsungKim,InhoHan,BongJooPark,JeongKooKim,DongWookHan,SooHyunKim,SeungJinLee,JongChulPark 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.3
Sterilization is an essential process for biodegradable polymers to be used as biomaterials or tissue engi-neered-scaffolds. The characteristics of biodegradable scaffolds can change due to decomposition of constituentpolymers due to high temperature, pressure, or moisture during sterilization. This study investigated direct-current (DC) treatment as a safe method that can prevent structural change and deformation. Treatment of electrospun poly (lactic-co-glycolic acid) (PLGA) with DC showed a bactericidal effect within 40 sec at 4 V. When DC was appliedat 6 V to the electrospun PLGA, the bactericidal effect emerged within 30 sec. The morphology of fibers and molec-ular weight of PLGA polymer was maintained after DC treatment. In contrast, electrospun PLGA exposed to ethyl-ene oxide showed fiber degradation, and gamma or e-beam irradiation resulted in decreased molecular weight. Thedemonstrated improvement in chemical and physical stability of biodegradable polymers after DC sterilization mayhelp extend their application.