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RISS 인기검색어
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- 저자 : Junchi Wang (검색결과 4 건)
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Chemical constituents from the fruiting bodies of Cryptoporus volvatus
Junchi Wang,Guangzhi Li,Na Lv,Li Gao,Liangang Shen,Jianyong Si 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
New drimane-type sesquiterpene cryptoporol A(1), cryptoporic acid derivative 60-cryptoporic acid E methylester (2), and pseudouridine derivative cryptoporineA(3), aswell as a known ergosterol 5a,8a-epidioxy-22E-ergosta-6,22-dien-3b-ol (4), were isolated from a 90 % alcoholextract of the fruiting bodies of Cryptoporus volvatus. Thestructures of these compounds were established by spectroscopicanalysis and circular dichroism. 5a,8a-epidioxy-22Eergosta-6,22-dien-3b-ol (4) exhibited antiviral activityagainst porcine reproductive and respiratory syndrome virus,and all compounds showed weak antioxidant activities.
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Wang, Yuli,Ma, Junchi,Du, Yifei,Miao, Jing,Chen, Ning Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.3
Epidemiological evidence suggests that bone is especially sensitive to oxidative stress, causing bone loss in the elderly. Previous studies indicated that human amnion-derived mesenchymal stem cells (HAMSCs), obtained from human amniotic membranes, exerted osteoprotective effects in vivo. However, the potential of HAMSCs as seed cells against oxidative stress-mediated dysfunction is unknown. In this study, we systemically investigated their antioxidative and osteogenic effects in vitro. Here, we demonstrated that HAMSCs significantly promoted the proliferation and osteoblastic differentiation of $H_2O_2$-induced human bone marrow mesenchymal stem cells (HBMSCs), and down-regulated the reactive oxygen species (ROS) level. Further, our results suggest that activation of the ERK1/2 MAPK signal transduction pathway is essential for both HAMSCs-mediated osteogenic and protective effects against oxidative stress-induced dysfunction in HBMSCs. U0126, a highly selective inhibitor of extracellular ERK1/2 MAPK signaling, significantly suppressed the antioxidative and osteogenic effects in HAMSCs. In conclusion, by modulating HBMSCs, HAMSCs show a strong potential in treating oxidative stress- mediated bone deficiency.
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Guangzhi Li,Junchi Wang,Xiaojin Li,Jianguo Xu,Zhao Zhang,Jianyong Si 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.6
20-Z auraptene (1) is a synthesized monoterpenecoumarin with anticancer activity against human gastriccancer cells. In order to find new potential anticancer agent,Mucor polymorphosporus was used to transform cis-auraptene. Four new terpene coumarins with notable changesin the skeletal backbone, 20-Z auraptene A-D (2–5), wereobtained and evaluated for their antiproliferative effectsagainst human normal gastric epithelium cells and humangastric cancer cells. These new compounds showed selectivecytotoxic activity against MGC-803 cells with IC50values from 0.78 ± 0.13 to 10.78 ± 1.83 lM and thetherapeutic index could also be significantly improved(TI = 59.0) compared with that of 1 (TI = 5.5). Thestructures of these metabolites were elucidated throughextensive spectroscopic methods, and the possible biotransformationpathway of 1 by Mucor polymorphosporuswas also proposed. Furthermore, the mechanism of theantiproliferative effects against MGC-803 cells of the mostpotent compound, 20-Z auraptene A (2), was characterized. Annexin V/PI staining and abnormal expression of apoptosis-related protein suggested that compound 2 inducesapoptosis in gastric cancer MGC-803 cells. Therefore, it ispossible that compound 2 has the potential to be applied ingastric cancer therapy.
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Ning Chen,Yuli Wang,Junchi Ma,Yifei Du,Jing Miao 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.3
Epidemiological evidence suggests that bone is especial-ly sensitive to oxidative stress, causing bone loss in the elderly. Previous studies indicated that human amnion-derived mesenchymal stem cells (HAMSCs), obtained from human amniotic membranes, exerted osteoprotective effects in vivo. However, the potential of HAMSCs as seed cells against oxidative stress-mediated dysfunction is unknown. In this study, we systemically investigated their antioxidative and osteogenic effects in vitro. Here, we demonstrated that HAMSCs significantly promoted the proliferation and osteoblastic differentiation of H2O2-induced human bone marrow mesenchymal stem cells (HBMSCs), and down-regulated the reactive oxygen species (ROS) level. Further, our results suggest that activation of the ERK1/2 MAPK signal transduction pathway is essential for both HAMSCs-mediated osteogenic and protective effects against oxidative stress-induced dysfunction in HBMSCs. U0126, a highly selective inhibitor of extracellular ERK1/2 MAPK signaling, significantly suppressed the antioxidative and osteogenic effects in HAMSCs. In conclusion, by modulating HBMSCs, HAMSCs show a strong potential in treating oxidative stress- mediated bone deficiency.
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