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Effectiveness of Home Visiting Treatment using Traditional Korean Medicine
Kim, Na-Young,Lee, Jae-Hoon,Go, Ho-Yeon,Youn, Sang-Jun,Lee, Jae-Hyok,Lee, Dong-Nyoung,Shin, Mi-Ran The Society of Korean Medicine 2011 대한한의학회지 Vol.32 No.6
Objectives: The study was investigated to assess efficacy for home visiting treatment using Traditional Korean Medicine (TKM). Methods: The traditional medical doctor of Um-Sung health center has treated the 109 patients and they also answered the questionnaires of home visiting treatment using TKM before and after. The questionnaires were composed of flexibility, pain, health behavior, perception of health, satisfaction, cognition of TKM, etc. The questionnaires were analyzed by use of paired t-test and chi-square test. Results: They have significantly improved the flexibility (p<.001), pain (p<.001), health behavior (p<.001), and the perception (p<.001) of health after home visiting treatment. It was also brought to improve about the perception of TKM, and showed a good satisfaction and the improvement of health. Conclusion: Home visiting treatment using TKM is helpful to improve the health based on these results. We need to systemize the research for the activation of home visiting treatment using TKM.
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Jun-Ran Kim,Chang Woo Ji,Bo Yoon Seo,Chang Gyu Park,Kwan-Seok Lee,Sang-Guei Lee 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
The insecticidal activity of 120 plant essential oils and control efficacy of six experimental spray formulations (SF) containing the oils (SF-0.25, 0.5, 1, 2.5, 5 and 10% sprays) against both nymph and adult of citrus flatid planthopper, Metcalfa pruinosa, was examined using a direct contact application. Reponses varied according to dose (1000 mg litre-1 and 500 mg litre-1). Based on 24 h exposure in leaf dipping assay at 1000 mg litre-1 strong mortality was observed in more than 19 essential oils among 130 was screened. At 500 mg litre-1 very strong mortality (100%) was observed in cinnamon technical, cinnamon green leaf, cinnamon #500, cassia tree, citronella java and penny royal followed by origanum, thyme white, grape fruit, savory, fennel sweet, aniseed and cinnamon bark (93.3- 80%) showed considerable moratality against nymphs of M. pruinosa. The moderate mortality was found in thyme red, tagette, calamus, lemoneucalptus and geranium (73.3-60%). The other oil has low or very low mortality against M. pruinosa. The oil applied as SF-10% sprays provided 100% mortality against adult M. pruinosa. In particular cinnamon technical showed very strong (>SF-0.5= 100%) effect followed by cinnamon #500 (>SF-2.5=100%), cinnamon green leaf (>SF-2.5=100%) and penny royal (>SF-2.5=100%) respectively. Global efforts to reduce the level of highly toxic synthetic insecticides in the agricultural environment justify further studies on the active essential oils as potential larvicides for the control of M. pruinosa populations as direct spray with contact action.
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Kim, Min-Sik,Choi, Ae Ran,Lee, Seong Hyuk,Jung, Hae-Chang,Bae, Seung Seob,Yang, Tae-Jun,Jeon, Jeong Ho,Lim, Jae Kyu,Youn, Hwan,Kim, Tae Wan,Lee, Hyun Sook,Kang, Sung Gyun American Society for Microbiology 2015 Applied and environmental microbiology Vol.81 No.5
<P>Genome analysis revealed the existence of a putative transcriptional regulatory system governing CO metabolism in <I>Thermococcus onnurineus</I> NA1, a carboxydotrophic hydrogenogenic archaeon. The regulatory system is composed of CorQ with a 4-vinyl reductase domain and CorR with a DNA-binding domain of the LysR-type transcriptional regulator family in close proximity to the CO dehydrogenase (CODH) gene cluster. Homologous genes of the CorQR pair were also found in the genomes of <I>Thermococcus</I> species and “<I>Candidatus</I> Korarchaeum cryptofilum” OPF8. In-frame deletion of either <I>corQ</I> or <I>corR</I> caused a severe impairment in CO-dependent growth and H<SUB>2</SUB> production. When <I>corQ</I> and <I>corR</I> deletion mutants were complemented by introducing the <I>corQR</I> genes under the control of a strong promoter, the mRNA and protein levels of the CODH gene were significantly increased in a ΔCorR strain complemented with integrated <I>corQR</I> (ΔCorR/<I>corQR</I><SUP>↑</SUP>) compared with those in the wild-type strain. In addition, the ΔCorR/<I>corQR</I><SUP>↑</SUP> strain exhibited a much higher H<SUB>2</SUB> production rate (5.8-fold) than the wild-type strain in a bioreactor culture. The H<SUB>2</SUB> production rate (191.9 mmol liter<SUP>−1</SUP> h<SUP>−1</SUP>) and the specific H<SUB>2</SUB> production rate (249.6 mmol g<SUP>−1</SUP> h<SUP>−1</SUP>) of this strain were extremely high compared with those of CO-dependent H<SUB>2</SUB>-producing prokaryotes reported so far. These results suggest that the <I>corQR</I> genes encode a positive regulatory protein pair for the expression of a CODH gene cluster. The study also illustrates that manipulation of the transcriptional regulatory system can improve biological H<SUB>2</SUB> production.</P>
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<i>Hominis placenta</i> Suppresses Acute Lung Inflammation by Activating Nrf2
Kim, Tae Ho,Choi, Jun-Yong,Kim, Kyun Ha,Kwun, Min Jung,Han, Chang-Woo,Won, Ran,Lee, Jung Ju,Kim, Jong-In,Joo, Myungsoo World Scientific Publishing Company 2018 The American journal of Chinese medicine Vol.46 No.4
<P><I>Hominis placenta</I> (HP), a dried human placenta, has been known to target liver, lung, or kidney meridians, improving the functions associated with these meridians in traditional Chinese or Asian medicine (TCM). Since recent studies implicate an HP extract in suppressing inflammation, we investigated whether an aqueous HP extract can ameliorate inflammation that occurred in the lungs. When administered with a single intratracheal lipopolysaccharide (LPS), C57BL/6 mice developed an acute neutrophilic lung inflammation along with an increased expression of pro-inflammatory cytokine genes. However, this was diminished by the administration HP extract via an intraperitoneal route 2 h after LPS treatment. Western blot and semi-quantitative RT-PCR analyses revealed that while suppressing the activity of a proinflammatory factor NF-<TEX>$ \kappa $</TEX>B marginally, the HP extract strongly activated an anti-inflammatory factor Nrf2, with concomitant expression of Nrf2-dependent genes. Mechanistically, the HP extract suppressed the ubiquitin-mediated degradation of Nrf2, functioning similarly to a 26S proteasome inhibitor, MG132. Collectively, these results suggest that the HP extract suppresses inflammation in mouse lungs, which is in part related to the HP extract perturbing the ubiquitin-dependent degradation of Nrf2 and thus increasing the function of Nrf2.</P>
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Kim, Tae Jun,Kim, Eun Ran,Hong, Sung Noh,Chang, Dong Kyung,Kim, Young-Ho Williams & Wilkins Co 2016 Medicine Vol.95 No.19
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>The prognosis of early-onset sporadic colorectal cancer (CRC) patients remains controversial. The objective of this study was to assess the long-term outcome and prognostic factors of sporadic CRC in young patients.</P><P>From 2006 to 2011, 8207 patients underwent curative or palliative surgery for CRCs in our institution. A total of 693 patients who were ≤45 years old with sporadic CRC were enrolled as the young group. A total of 1823 patients aged between 56 and 65 years were identified as middle-aged control group for this study. Survival outcome and prognostic factors were compared between the two groups.</P><P>Young patients had higher recurrence rate than older patients in stages I and II (8.8% vs 2.7%, <I>P</I> <0.001). There was no significant difference of recurrence rate in stage III and IV cancers (27.5% vs 27.9%, <I>P</I> = 0.325). Metachronous cancers were developed more frequently in young patients (1.4% vs 0.6%, <I>P</I> = 0.038). Advanced stage CRC was diagnosed significantly more common in the young group (55.6% vs 47.9%, <I>P</I> = 0.001). High microsatellite instability (MSI) tumors are less likely to have advanced stage cancers (odds ratio (OR) 0.23, 95% confidence interval (CI) = 0.07–0.70) or cancer recurrence (OR 0.11, 95% CI = 0.01–0.85) in young patients. Cancer-specific survival was worse in young patients than that in older patients (81.2% vs 87.8%, <I>P</I> <0.001). However, there was no significant difference in cancer-specific survival for each stage between the two groups. Independent prognostic factors for survival in young patients were undifferentiated cancer (hazard ratio (HR) 2.30, 95% CI = 1.23–4.31) and 3 months or longer duration of symptom (HR 2.57, 95% CI = 1.34–4.94). Young women had better survival compared with young men (HR 0.55, 95% CI = 0.33–0.90).</P><P>Prognosis of sporadic CRC in young patients is poorer than older patients, because of poorer histologic differentiation and delay in diagnosis. Early detection of CRC confers survival benefit to young patients. Because of higher recurrence rate and metachronous cancer risk, post-operative surveillance is also important in young patients.</P></▼2>
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Jun-Gyo In,Min-Kyeoung Kim,Ok Ran Lee,Yu-Jin Kim,Beom-Soo Lee,Se-Young Kim,Woo-Seang Kwon,Deok-Chun Yang 고려인삼학회 2010 Journal of Ginseng Research Vol.34 No.1
Expensive herbs such as ginseng are always a possible target for fraudulent labeling. New mountain ginseng strains have occasionally been found deep within mountain areas and commercially traded at exorbitant prices. However, until now, no scientific basis has existed to distinguish such ginseng from commonly cultivated ginseng species other than by virtue of being found within deep mountain areas. Polymerase chain reaction (PCR) analysis of the internal transcribed spacer has been shown to be an appropriate method for the identification of the most popular species (Panax ginseng) in the Panax ginseng genus. A single nucleotide polymorphism (SNP) has been identified between three newly found mountain ginseng (KGD4, KGD5, and KW1) and already established Panax species. Specific PCR primers were designed from this SNP site within the sequence data and used to detect the mountain ginseng strains via multiplex PCR. The established multiplex-PCR method for the simultaneous detection of newly found mountain ginseng strains, Korean ginseng, and foreign ginseng in a single reaction was determined to be effective. This study is the first report of scientific discrimination of “mountain ginsengs” and describes an effective method of identification for fraud prevention and for uncovering the possible presence of other, cheaper ginseng species on the market.
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Jun-Yong Choi,Bom Choi,Ojin Kwon,Chang-Seob Seo,Ae-Ran Kim,Hyeun-kyoo Shin,Kibong Kim 한국한의학연구원 2024 Integrative Medicine Research Vol.13 No.1
Background: Gongjin-dan (GJD, also known as Gongchen-dan) and Ssanghwa-tang (SHT, also known as Shuanghe-tang or Souwa-to) are herbal medicines that are widely used in Korea for treating fatigue. However, few studies have evaluated the efficacy and safety of GJD and SHT in the treatment of chronic fatigue. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 90 individuals with persistent (≥6 months) chronic fatigue of unknown cause and a Fatigue Severity Scale (FSS) score of ≥4 were randomly assigned to GJD group, SHT group, and control group in a 1:1:1 ratio. Outcomes were the changes in the self-reported fatigue questionnaire scores, levels of fatigue-related biomarkers and safety assessment. Results: Out of 103 patients recruited, 90 were included in the analysis. A significant improvement in the Social Functioning (SF) score of Short-Form 36 Health Survey (SF-36) at week 4 was observed in the GJD group; similarly, a significant improvement compared with that in the Control group was observed in the Role Emotional (RE) score of SF-36 at weeks 4 and 6 and the Physical Functioning (PF) score of SF-36 at week 6 in the SHT group. Laboratory tests revealed no abnormalities, and serious intervention-related adverse events were not reported. Conclusions: It is suggested that SHT can effectively treat chronic mental and physical fatigue, whereas GJD can effectively treat chronic mental and social fatigue. Furthermore, this study presents evidence supporting the safety of the long-term use of GJD and SHT (up to 4 weeks). Trial registration: This study was registered at Clinical Research Information Service (CRIS) of Korea with the registration number KCT0007515. Background: Gongjin-dan (GJD, also known as Gongchen-dan) and Ssanghwa-tang (SHT, also known as Shuanghe-tang or Souwa-to) are herbal medicines that are widely used in Korea for treating fatigue. However, few studies have evaluated the efficacy and safety of GJD and SHT in the treatment of chronic fatigue. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 90 individuals with persistent (≥6 months) chronic fatigue of unknown cause and a Fatigue Severity Scale (FSS) score of ≥4 were randomly assigned to GJD group, SHT group, and control group in a 1:1:1 ratio. Outcomes were the changes in the self-reported fatigue questionnaire scores, levels of fatigue-related biomarkers and safety assessment. Results: Out of 103 patients recruited, 90 were included in the analysis. A significant improvement in the Social Functioning (SF) score of Short-Form 36 Health Survey (SF-36) at week 4 was observed in the GJD group; similarly, a significant improvement compared with that in the Control group was observed in the Role Emotional (RE) score of SF-36 at weeks 4 and 6 and the Physical Functioning (PF) score of SF-36 at week 6 in the SHT group. Laboratory tests revealed no abnormalities, and serious intervention-related adverse events were not reported. Conclusions: It is suggested that SHT can effectively treat chronic mental and physical fatigue, whereas GJD can effectively treat chronic mental and social fatigue. Furthermore, this study presents evidence supporting the safety of the long-term use of GJD and SHT (up to 4 weeks). Trial registration: This study was registered at Clinical Research Information Service (CRIS) of Korea with the registration number KCT0007515.
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