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pH-Responsive Hyaluronic Acid-Based Nanocarrier for Treatment of Rheumatoid Arthritis
Jeon, Jueun,Rao, N. Vijayakameswara,Byun, Jae Hyun,Heo, Roun,Han, Hwa Seung,Park, Jae Hyung American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.11
<P>To develop a potential nanocarrier for diagnosis and treatment of rheumatoid arthritis (RA), we prepared a hyaluronic acid (HA)-5 beta-cholanic acid (CA) conjugate with an acid-labile ketal linker. This conjugate could self-assemble in aqueous conditions to produce pH-responsive HA-CA nanoparticles as potential carriers of the anti-inflammatory drug methotrexate (MTX). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released from nanoparticles under mildly acidic conditions similar to the environment of inflamed synovial tissue in RA. In vitro cytotoxicity data showed that pH-responsive HA-CA nanoparticles were non-toxic to RAW 264.7 cells. In vivo biodistribution results confirmed that, after their systemic administration, pH-responsive HA-CA nanoparticles selectively accumulated in the inflamed joints of collagen-induced arthritis mice. These results indicate that pH-responsive HA-CA nanoparticles represent a promising candidate as a drug carrier for RA therapy.</P>
C 언어로 구현된 스마트 그리드 모니터링 시스템을 위한 LabVIEW와 C 언어의 TCP/IP통신
김주은(Jueun Kim),최남섭(Nam-Sup Choi),양효식(Hyo-Sik Yang),한병문(Byung-Moon Han) 전력전자학회 2010 전력전자학술대회 논문집 Vol.2010 No.11
In smart grid system which uses photovoltaic system, fuel cells and so on, a program implemented with C language is used for control and measurement. When using programs implemented with C language GUI is difficult to watch control and monitor the smart grid system. But LabVIEW is a graphical programming language and it is easy to design GUI screen and to manage many variables such as real-time output of electric power including solar cell, wind power system and fuel cell. This paper suggests LabVIEW and C-language TCP/IP communication for smart grid monitoring system implemented with C-language.
매립가스 및 폐플라스틱의 친환경 분해를 통한 수소·탄소 활용 네트워크 구축
한효림 ( Hyorim Han ),성인호 ( In-ho Seong ),서원덕 ( Wondeok Seo ),조은정 ( Eunjeong Cho ),백주은 ( Jueun Baek ),송태진 ( Tai-jin Song ) 충북대학교 건설기술연구소 2023 建設技術論文集 Vol.42 No.2
The current method used to recycle waste, which is responsible for more than 30% of methane generation, has limitations, including the combustion stage, which can cause additional environmental pollution during the recycling process. In addition, as the amount of waste synthetic resin entering landfills increases due to the activation of delivery services, the government has advocated the need to minimize the incineration and landfilling of waste synthetic resin. In this study, we propose 1) an eco-friendly way to resource landfill gas and waste synthetic resin generated in landfills by introducing a pyrolysis method using Ni-based catalysts, and 2) a network system that can environmentally utilize hydrogen, carbon, and carbon dioxide generated through the pyrolysis method. Finally, 3) we attempted to quantitatively calculate the environmental benefits of applying the proposed network to the Cheongju Metropolitan Landfill. Accordingly, a plan to utilize Ni-based catalysts, which have a methane conversion rate of about 1.5 times that of Si-based catalysts, was proposed, and the hydrogen generated in the process can be utilized as a fuel cell, and carbon and carbon dioxide can be utilized by establishing a carbon/carbon dioxide industry cluster around the landfill, which can bring environmental and economic benefits to the local government. As a result of applying the proposed network to the Cheongju Metropolitan Landfill, it was found that using hydrogen fuel cells to operate vehicles in the intercity bus terminal can reduce the use of fossil fuels by about 12,846.2 liters per day, which can reduce carbon dioxide by about 67 tons per month. The study also showed that if a C/CO2 industry cluster is built using the surrounding land, it can be used to reduce dependence on high carbon imports and lay the foundation for building a carbon-independent city. The results of this study can be applied to other local governments with landfills and are expected to help them achieve carbon neutrality and build carbon-independent cities.
한상선(Sangsun Han),김민곤(Mingon Kim),신주은(Jueun Shin),이승연(SeungYon-Seny Lee) 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
건강에 대한 관심이 높아짐에 따라 운동을 보조해줄 수 있는 헬스케어 앱에 대한 수요도 많아지고 있다. 하지만 기존 모바일 헬스케어 앱들은 단순히 텍스트, 동영상을 제공함으로써 사용자들에게 충분히 유의사항을 인지시키지 못하고 부상을 막는데 한계가 있었다. 본 연구에서는 Tensorflow 에서 제공하는 PoseNet 인공지능을 활용하여 사용자의 신체를 인식하고 자세에 대한 피드백을 줄 수 있는 앱을 제안하고자 한다. 이를 통해 사용자들은 제대로 된 자세로 운동하여 최고의 효과를 얻을 것으로 기대된다.