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- 저자 : Ju-Won Kang,Dong-Min Kim,Hyun-Sook Lee,Yeo-Tae Yoon,Sang-Nag Ahn (검색결과 2,370 건)
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Kang Nam-goo,Jeong Won-jeong,Ko Min-ju,Oh Jae-seop 한국전문물리치료학회 2023 한국전문물리치료학회지 Vol.30 No.2
Background: The gluteus maximus (GM) muscle comprise the lumbo-pelvic complex and is an important stabilizing muscle during leg extension. In patients with low back pain (LBP) with weakness of the GM, spine leads to compensatory muscle activities such as instantaneous increase of the erector spinae (ES) muscle activity. Four-point kneeling arm and leg lift (FKALL) is most common types of lumbopelvic and GM muscles strengthening exercise. We assumed that altered hip position during FKALL may increase thoraco-lumbar stabilizer like GM activity more effectively method. Objects: The purpose of this study was investigated that effects of the three exercise postures on the right-sided GM, internal oblique (IO), external oblique (EO), and multifidus (MF) muscle activities and pelvic kinematic during FKALL. Methods: Twenty eight healthy individuals participated in this study. The exercises were performed three conditions of FKALL (pure FKALL, FKALL with 120° hip flexion of the supporting leg, FKALL with 30° hip abduction of the lifted leg). Participants performed FKALL exercises three times each condition, and motion sensor used to measure pelvic tilt and rotation angle. Results: This study demonstrated that no significant change in pelvic angle during hip movement in the FKALL (p > 0.05). However, the MF and GM muscle activities in FKALL with hip flexion and hip abduction is greater than pure FKALL position (p < 0.001). Conclusion: Our finding suggests that change the posture of the hip joint to facilitate GM muscle activation during trunk stabilization exercises such as the FKALL.
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Ju-Won Kang,Dong-Min Kim,Sangshetty,Hyun-Sook Lee,Sang-Nag Ahn 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Drought stress is one of the major stress affecting growth and productivity in rice. Drought tolerance is a complex trait governed by quantitative trait loci (QTLs) making it difficult to understand mechanisms underlying it. We generated a set of 55 introgression lines via a backcrossing using Milyang23, a Korean Tongil-type rice variety as the recurrent parent and O. glaberrima (IRGC Acc. No. 103544), an exotic collection from Mali, West Africa as donor parent. 141 SSR markers were used to genotype 55 introgression lines. The 55 introgression lines with the Milyang23 were evaluated for physiological traits such as Fresh shoot weight (FSW), Fresh root weight (FRW) and Dry shoot weight (DSW) under control and 20% PEG-treated condition. Three lines (IL9, 12, 55) showing significant difference with Milyang23 were selected. The genetic background of the three lines were similar to Milyang23 and it has four, four and two O. glaberrima homozygous segments, respectively. IL9 performed better than Milyang23 in all traits measured in the 20% PEG-treated condition. IL9 possessed four O. glaberrima introgressions on chromosomes 1, 2, 6 and 7. IL12 performed better than Milyang23 in FSW and FRW. IL12 contains four O. glaberrima introgressions on chromosomes 3 and 6. And IL55 contains two O. glaberrima introgressions on chromosomes 2 and 6. O. glaberrima segment delimited by markers OSR19-RM225 at chromosomes 6 was commonly present in these three lines. This region corresponds to the QTL region for drought tolerance reported by other previous studies. A set of introgression lines are being developed containing only few chromosomal segments from O. glaberrima in the Milyang23 background. These would be useful not only in developing drought tolerant lines in the breeding program but also in fine-mapping the genes/QTLs for drought resistance.
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Kang, Joo-Won,Cho, Won-Ju Elsevier 2019 Solid-state electronics Vol.152 No.-
<P><B>Abstract</B></P> <P>Sensing properties of various high-k sensing membrane, such as SnO<SUB>2</SUB>, HfO<SUB>2</SUB>, ZrO<SUB>2</SUB>, and Ta<SUB>2</SUB>O<SUB>5</SUB>, in dual gate extended-gate field-effect transistor (EGFET) were investigated. By adapting the dual-gate structure, high sensitivity exceeding the conventional Nernstian limit on sensitivity (59.15 mV/pH at 25 °C) was realized due to capacitive coupling effect. As a results, it was confirmed that dual-gate EGFET with Ta<SUB>2</SUB>O<SUB>5</SUB> sensing membrane which has high permittivity shows the highest sensitivity of 478.0 mV/pH as well as excellent hysteresis voltage and drift rate characteristics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We evaluated the effect of extended-gate filed-effect transistor (EGFET) sensors. </LI> <LI> We used a dual gate structure transducer to overcome the theoretical Nernstian limit. </LI> <LI> We found that the Ta<SUB>2</SUB>O<SUB>5</SUB> sensing membrane has the highest sensitivity of 478.0 mV/pH. </LI> </UL> </P>
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Kang, Seung-Ji,Jin, Hye-Mi,Won, Eun Jeong,Cho, Young-Nan,Jung, Hyun-Ju,Kwon, Yong-Soo,Kee, Hae Jin,Ju, Jae Kyun,Kim, Jung-Chul,Kim, Uh Jin,Jang, Hee-Chang,Jung, Sook-In,Kee, Seung-Jung,Park, Yong-Wook Public Library of Science 2016 PLoS neglected tropical diseases Vol.10 No.7
<▼1><P><B>Background</B></P><P>Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in <I>Orientia tsutsugamushi</I> infection. Hence, the aims of this study were to examine the level and function of MAIT cells in patients with scrub typhus and to evaluate the clinical relevance of MAIT cell levels.</P><P><B>Methodology/Principal Findings</B></P><P>Thirty-eight patients with scrub typhus and 53 health control subjects were enrolled in the study. The patients were further divided into subgroups according to disease severity. MAIT cell level and function in the peripheral blood were measured by flow cytometry. Circulating MAIT cell levels were found to be significantly reduced in scrub typhus patients. MAIT cell deficiency reflects a variety of clinical conditions. In particular, MAT cell levels reflect disease severity. MAIT cells in scrub typhus patients displayed impaired tumor necrosis factor (TNF)-α production, which was restored during the remission phase. In addition, the impaired production of TNF-α by MAIT cells was associated with elevated CD69 expression.</P><P><B>Conclusions</B></P><P>This study shows that circulating MAIT cells are activated, numerically deficient, and functionally impaired in TNF-α production in patients with scrub typhus. These abnormalities possibly contribute to immune system dysregulation in scrub typhus infection.</P></▼1><▼2><P><B>Author Summary</B></P><P>Scrub typhus is a mite-borne bacterial infection in humans caused by <I>Orientia tsutsugamushi</I>, an obligate intracellular bacterium, prevalent in Asia, Northern Australia, and the Indian subcontinent. The pathogenesis of <I>O</I>. <I>tsutsugamushi</I> infection is known to be not only related to the virulence of <I>O</I>. <I>tsutsugamushi</I>, but also to the host immune response. Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved antimicrobial MR1-restricted T cell subset. Upon antigen recognition, MAIT cells rapidly produce proinflammatory cytokines, maintain an activated phenotype throughout the course of an infection, and have the potential to directly kill infected cells; thus, playing an important role in controlling the host response. However, little is known about the role of MAIT cells in <I>Orientia tsutsugamushi</I> infection. To the best of our knowledge, this is the first study to measure the levels and functions of circulating MAIT cells in scrub typhus patients and to examine the clinical relevance of MAIT cell levels. The present study demonstrates that circulating MAIT cells are activated and numerically deficient in patients with scrub typhus. Notably, impairment of TNF-α production represents the susceptibility of individuals to <I>O</I>. <I>tsutsugamushi</I> infection. These findings provide important information for predicting the prognosis of scrub typhus infection.</P></▼2>
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Kang, Min-Soo,Cho, Won-Ju Elsevier 2018 The Journal of physics and chemistry of solids Vol.123 No.-
<P><B>Abstract</B></P> <P>In this study, we fabricated ReRAM devices with the structure Ti/AlO<SUB> <I>x</I> </SUB>/Pt by applying solution-processed AlO<SUB> <I>x</I> </SUB> film as the switching layer. This enabled us to analyze the effect of the MWI power on the resistive switching performance of ReRAM. The AlO<SUB> <I>x</I> </SUB> resistive switching layer deposited by the solution-process was subjected to PDA treatment with microwave power ranging from 600 W to 3000 W, and the resistive switching performance was compared with as-dep and CTA-processed ReRAMs. All AlO<SUB> <I>x</I> </SUB>-based ReRAM devices exhibited bipolar resistive switching characteristics, and MWI-treated devices had larger memory windows than as-dep and CTA-treated devices. These solution-processed AlO<SUB> <I>x</I> </SUB> ReRAMs were found to exhibit Ohmic conduction in the low-voltage range of both the LRS and HRS. The high-voltage range of HRS shows the Poole-Frenkel conduction mechanism. In addition, compared with the as-dep device, the PDA-treated devices exhibited stable endurance characteristics and uniform resistance distribution in 1000 cycles of the switching operation, and showed reliable retention characteristics for 10,000 s at both room temperature and high temperature. XPS measurements were performed to analyze the relationship between the resistive switching performance and chemical nature of the AlO<SUB> <I>x</I> </SUB> switching layer by varying the microwave power and heat treatment method.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Resistive switching of resistive random access memory (ReRAM) devices was studied. </LI> <LI> Microwave irradiation (MWI) power of ReRAM solution-treated AlO<SUB>x</SUB> switching layers. </LI> <LI> Effect of MWI ranging from 600 W to 3000 W evaluated. </LI> <LI> Memory characteristics improved as MWI power increased. </LI> <LI> X-ray photoelectron spectroscopy showed that oxygen increased stoichiometrically. </LI> </UL> </P>
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Kang, Nae-Won,Kim, Min-Hwan,Sohn, Seo-Yeon,Kim, Ki-Taek,Park, Ju-Hwan,Lee, Sun-Young,Lee, Jae-Young,Kim, Dae-Duk Elsevier 2018 Biomaterials Vol.182 No.-
<P><B>Abstract</B></P> <P>Cellulose nanofiber (CNF) is an attractive biomaterial given its film-forming properties, excellent mechanical properties and biocompatibility. Herein, CNF film was prepared as a topical drug delivery system by hybridizing curcumin (Cur)-loaded nanostructured lipid carriers (NLCs). NLCs with a mean diameter of ≈500 nm were fabricated by using a solvent diffusion method. The lipid composition of the NLCs was optimized based on the efficiency of Cur delivery to the artificial skin and mechanical strength of the developed films, where a composition containing shea butter and Capmul MCM EP exhibited the highest values of 233.2 ± 96.6 μg/cm<SUP>2</SUP>/mg and 4.86 ± 0.14 MPa, respectively. The Cur-loaded lipid-hybridized CNF (lipid@CNF) films with a smooth rather than particle-embedded surface were obtained by vacuum filtration of the NLCs and CNF mixture, which were confirmed by TEM, SEM, AFM, XPS, and FTIR analyses. The Cur-loaded lipid@CNF films exhibited more than 2.0-fold increases in Cur deposition to the epidermis of imiquimod (IMQ)-induced psoriatic mouse compared with the films without lipids, which potentially resulted from the amorphous state of Cur observed in the DSC and PXRD analyses and the permeation-enhancing effect of lipids. The <I>in vivo</I> anti-psoriatic efficacy test revealed that the Cur-loaded lipid@CNF films ameliorated the psoriatic skin symptoms in IMQ-induced mice, reducing the pro-inflammatory cytokine levels in the skin almost comparable to a commercially available topical corticosteroid cream. These results could be attributed to the enhanced Cur deposition along with the skin hydration effect of the films. These findings suggest that the developed CNF films can be used as a promising topical drug delivery system for psoriasis therapy.</P>
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