http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effect of Cadmium on Radial Growth and Dry Mass Production of Ectomycorrhizal Fungi
김창기,Sally Anne Power,John Nigel Berridge Bell 한국생태학회 2004 Journal of Ecology and Environment Vol.27 No.5
The sensitivity to Cd of three ectomycorrhizal fungi, Paxillus involutus, Suillus bovinus and Rhizopogon subcaerulescens, was assessed and compared in terms of radial growth and dry mass production, using both agar and liquid culture. The radial growth of S. bovinus and R. subcaerulescens was significantly reduced at the lowest concentration (0.1 mg Cd/L). The 50% effective concentration (EC50) values calculated from radial growth rates of the ectomycorrhizal fungi showed that the sensitivity of the fungi to Cd was greatest in S. bovinus and lowest in R. subcaerulescens. Cadmium addition also significantly decreased dry mass production of the ectomycorrhizal fungi. The sensitivity of the fungi to Cd in terms of dry mass production, was greatest in S. bovinus and lowest in P. involutus. Higher growth rates of P. involutus and melanisation of R. subcaerulescens appeared to contribute to reduced Cd toxicity.
Development of targeted oncolytic virotherapeutics through translational research
Liu, Ta-Chiang,Hwang, Tae-Ho,Bell, John C,Kirn, David H Informa UK (Ashley Publications) 2008 Expert opinion on biological therapy Vol.8 No.9
<P>BACKGROUND: Oncolytic virotherapeutics is a promising platform for cancer treatment but the product class has yet been successful. The key to success is integration of bidirectional translational research to rapidly address issues encountered in the laboratory and the clinics. OBJECTIVE: We highlight the hurdles identified for the targeted oncolytic virotherapy approach, specifically those identified in clinical trials with wild-type viruses and first-generation targeted agents. We also analyze the translational research and development that has been applied to overcome these hurdles, including virus engineering and design improvements for next-generation virotherapeutics. RESULTS/CONCLUSION: The iterative loop between the clinic and the lab can function as a major driving force to optimize products from this platform.</P>
Effects of Cadmium on Radial Growth and Dry Mass Production of Ectomycorrhizal Fungi
Kim, Chang-Gi,Power, Sally Anne,Bell, John Nigel Berridge The Ecological Society of Korea 2004 Journal of Ecology and Environment Vol.27 No.5
The sensitivity to Cd of three ectomycorrhizal fungi, Paxillus involutus, Suillus bovinus and Rhizopogon subcaerulescens, was assessed and compared in terms of radial growth and dry mass production, using both agar and liquid culture. The radial growth of S. bovinus and R. subcaerulescens was significantly reduced at the lowest concentration (0.1mg Cd/L). The 50% effective concentration (EC$_{50}$) values calculated from radial growth rates of the ectomycorrhizal fungi showed that the sensitivity of the fungi to Cd was greatest in S. bovinus and lowest in R. subcaerulescens. Cadmium addition also significantly decreased dry mass production of the ectomycorrhizal fungi. The sensitivity of the fungi to Cd in terms of dry mass production, was greatest in S. bovinus and lowest in P. involutus. Higher growth rates of P. involutus and melanisation of R. subcaerulescens appeared to contribute to reduced Cd toxicity.
Mok, Samuel C.,Bonome, Tomas,Vathipadiekal, Vinod,Bell, Aaron,Johnson, Michael E.,Wong, kwong-kwok,Park, Dong-Choon,Hao, Ke,Yip, Daniel K.P.,Donninger, Howard,Ozbun, Laurent,Samimi, Goli,Brady, John,R Elsevier 2009 CANCER CELL Vol.16 No.6
<P><B>Summary</B></P><P>Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (<I>MAGP2</I>) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the α<SUB>V</SUB>β<SUB>3</SUB> integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.</P>
Nitric-acid Hydrolysis of Miscanthus giganteus to Sugars Fermented to Bioethanol
Fuxin Yang,Waheed Afzal,Kun Cheng,Nian Liu,Markus Pauly,Alexis T. Bell,Zhigang Liu,John M. Prausnitz 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.2
Miscanthus giganteus (M. giganteus) is a promising feedstock for the production of bioethanol or biochemicals. Using only dilute nitric acid, this work describes a two-step process for hydrolyzing hemicellulose and cellulose to fermentable sugars. Primary variables were temperature and reaction time. The solid-to-liquid mass ratio was 1:8. No enzymes were used. In the first step, M. giganteus was contacted with 0.5 wt.% nitric acid at temperatures between 120 and 160°C for 5 to 40 min. The second step used 0.5 or 0.75 wt.% nitric acid at temperatures between 180 and 210°C for less than 6 min. Under selected conditions, almost all hemicellulose and 58% cellulose were transferred to the liquid phase. Small amounts of degradation products were observed. The xylose solution obtained from the nitric-acid hydrolysis was fermented for 96 h and the glucose solution for 48 h to yield 0.41 g ethanol/g xylose and 0.46 g ethanol/g glucose. To characterize residual solids and the liquor from both steps, nuclear-magneticresonance (NMR) spectroscopy was performed for each fraction. The analytical data indicate that the liquid phase from Steps 1 and 2 contain little lignin or lignin derivatives.