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JO, GUK HEUI,KIM, GI-YOUNG,KIM, WUN-JAE,PARK, KUN YOUNG,CHOI, YUNG HYUN Spandidos Publications 2014 International journal of oncology Vol.45 No.4
<P>Sulforaphane, a naturally occurring isothiocyanate found in cruciferous vegetables, has received a great deal of attention because of its ability to inhibit cell proliferation and induce apoptosis in cancer cells. In this study, we investigated the anticancer activity of sulforaphane in the T24 human bladder cancer line, and explored its molecular mechanism of action. Our results showed that treatment with sulforaphane inhibited cell viability and induced apoptosis in T24 cells in a concentration-dependent manner. Sulforaphane-induced apoptosis was associated with mitochondria dysfunction, cytochrome?c release and Bcl-2/Bax dysregulation. Furthermore, the increased activity of caspase-9 and -3, but not caspase-8, was accompanied by the cleavage of poly ADP-ribose polymerase, indicating the involvement of the mitochondria-mediated intrinsic apoptotic pathway. Concomitant with these changes, sulforaphane triggered reactive oxygen species (ROS) generation, which, along with the blockage of sulforaphane-induced loss of mitochondrial membrane potential and apoptosis, was strongly attenuated by the ROS scavenger N-acetyl-L-cysteine. Furthermore, sulforaphane was observed to activate endoplasmic reticulum (ER) stress and the nuclear factor-E2-related factor-2 (Nrf2) signaling pathway, as demonstrated by the upregulation of ER stress?related proteins, including glucose-regulated protein 78 and C/EBP-homologous protein, and the accumulation of phosphorylated Nrf2 proteins in the nucleus and induction of heme oxygenase-1 expression, respectively. Taken together, these results demonstrate that sulforaphane has antitumor effects against bladder cancer cells through an ROS-mediated intrinsic apoptotic pathway, and suggest that ER stress and Nrf2 may represent strategic targets for sulforaphane-induced apoptosis.</P>
LCD-Panel에서 MURA 검출을 위한 CNN 활용
조국한(Guk-Han Jo),조현우(Hyun-Woo Cho),허영욱(Youngwook Heo),송영준(Young-Joon Song) 대한전자공학회 2020 대한전자공학회 학술대회 Vol.2020 No.8
There are direct visual and machine vision methods to detect MURA in LCD panels. The direct visual method shows inconsistent results depending on the status of testers and poor MURA detection performance. The machine vision detection method is not good at detection of various forms of MURA. To solve these problems, this paper uses a representative model of machine learning, that is CNN(Convolutional Neural Network), to detect MURA. The CNN model used in this paper consists of five convolution layers and two fully connected layers. As a result of the experiment using the proposed method shows the 96% accuracy of MURA detection and takes 0.145 seconds for one panel test.
( Chan Guk Park ),( Mei Jin Wu ),( Chansik Hong ),( Ju Yeon Jo ),( Han Yi Jiao ),( Hyun Park ),( Jae Yeoul Jun ),( Seok Choi ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.1
Background/Aims We investigated the role of representative endoplasmic reticulum proteins, stromal interaction molecule 1 (STIM1), and store-operated calcium entry-associated regulatory factor (SARAF) in pacemaker activity in cultured interstitial cells of Cajal (ICCs) isolated from mouse small intestine. Methods The whole-cell patch clamp technique applied for intracellular calcium ions ([Ca<sup>2+</sup>]i) analysis with STIM1 or SARAF overexpressed cultured ICCs from mouse small intestine. Results In the current-clamping mode, cultured ICCs displayed spontaneous pacemaker potentials. External carbachol exposure produced tonic membrane depolarization in the current-clamp mode, which recovered within a few seconds into normal pacemaker potentials. In STIM1-overexpressing cultured ICCs pacemaker potential frequency was increased, and in SARAF-overexpressing ICCs pacemaker potential frequency was strongly inhibited. The application of gadolinium (a non-selective cation channel inhibitor) or a Ca<sup>2+</sup>-free solution to understand Orai channel involvement abolished the generation of pacemaker potentials. When recording intracellular Ca<sup>2+</sup> concentration with Fluo 3-AM, STIM1-overexpressing ICCs showed an increased number of spontaneous intracellular Ca<sup>2+</sup> oscillations. However, SARAF-overexpressing ICCs showed fewer spontaneous intracellular Ca<sup>2+</sup> oscillations. Conclusion Endoplasmic reticulum proteins modulated the frequency of pacemaker activity in ICCs, and levels of STIM1 and SARAF may determine slow wave patterns in the gastrointestinal tract. (J Neurogastroenterol Motil 2018;24:128-137)