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Jeong, Jiwoon,Kim, Seeun,Park, Kee Hwan,Kang, Ikjae,Park, Su-Jin,Yang, Siyeon,Oh, Taehwan,Chae, Chanhee Elsevier 2018 Veterinary microbiology Vol.214 No.-
<P><B>Abstract</B></P> <P>A porcine reproductive and respiratory syndrome virus (PRRSV) modified live-virus (MLV) vaccine was evaluated under field conditions for registration as recommended by the Republic of Korea's Animal, Plant & Fisheries Quarantine & Inspection Agency. A single dose of the vaccine was administered to 1-day-old piglets and their growth performance was monitored under field conditions. Three separate farms were selected based on their history of PRRSV-associated respiratory diseases. On each farm, 40 pigs were randomly allocated to one of two treatment groups: (i) vaccinated (<I>n</I> = 20) and (ii) unvaccinated (<I>n</I> = 20) pigs at 1 day of age. Vaccinated pigs showed an increase of their market weight of 6.23 kg/pig compared to the unvaccinated pigs (98.01 kg in vaccinated group vs. 91.78 kg in unvaccinated group; <I>P <</I> 0.05) and exhibited a decrease in mortality rate by 6.7% (3.3% in vaccinated group vs. 10% in unvaccinated group; <I>P <</I> 0.05). The pigs had a sufficiently mature immune system for the vaccine to elicit humoral and cell-mediated immunity (as measured by anti-PRRSV antibodies and PRRSV-specific interferon-γ secreting cells, respectively) at 1 day of age even in the presence of maternally derived antibodies. The results presented in this study demonstrate that the PRRSV MLV vaccine is effective in improving growth performance from day 1 all the way to day 182 in endemic farms suffering with PRRSV-2 infection or both PRRSV-1 and PRRSV-2 infection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PRRSV vaccination at 1-day-old elicits anti-PRRSV antibodies even in the presence of maternally derived antibodies. </LI> <LI> PRRSV vaccination at 1-day-old induces PRRSV-specific interferon-γ secreting cells. </LI> <LI> PRRSV vaccination at 1-day-old improves growth performance from day 1 all the way to day 182 in endemic farms. </LI> </UL> </P>
Jeong, Jiwoon,Kim, Seeun,Park, Kee Hwan,Kang, Ikjae,Park, Su-Jin,Park, Changhoon,Chae, Chanhee Elsevier 2017 Veterinary microbiology Vol.208 No.-
<P><B>Abstract</B></P> <P>The efficacy of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine in reproductive performance was evaluated under field conditions. Three PRRS endemic farms were selected based on their history of PRRS-associated reproductive failures. On each farm, a total of 40 sows were randomly allocated to either vaccinated (<I>n</I> =20) or unvaccinated (<I>n</I> =20) groups. Sows were vaccinated six weeks prior to breeding. Clinical data showed a significant improvement in reproductive performance in vaccinated sows. Sows in the vaccinated groups had a significantly (<I>P<</I> 0.05) reduced number of stillborn piglets in all 3 farms. Sows in the vaccinated groups also had a significantly (<I>P<I> <</I> </I> 0.05) higher number of live-born piglets in one of the farms. Sows in the vaccinated groups had a significantly (<I>P<I> <</I> </I> 0.05) higher number of weaned piglets in two of the farms. Premature farrowing, one of the late gestation symptoms of PRRS, was also reduced due to vaccination as suggested by the increase in gestation length and the reduction in the number of stillborn piglets. No adverse systemic or local side effects relative to vaccination were observed during the entire gestation. No vaccine strain was detected in the vaccinated sows from all three farms at 70 and 114days post vaccination and in live-born piglets at the time of farrowing. Vaccination of sows with this PRRS vaccine was effective in improving reproductive performance in endemic PRRS farms.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The PRRSV MLV reduced numbers of stillborn piglets. </LI> <LI> The PRRSV MLV increased number of weaned piglets. </LI> <LI> No adverse effects relative to vaccination were observed during the entire gestation. </LI> </UL> </P>
Jeong, Jiwoon,Kim, Seeun,Park, Changhoon,Kang, Ikjae,Park, Kee Hwan,Ham, Hee Jin,Chae, Chanhee BMJ Group Group Ltd 2018 The Veterinary record Vol.182 No.21
<P>The objective of this field study was to evaluate the reproductive performance of sows after vaccination with a porcine reproductive and respiratory syndrome (PRRS) subunit vaccine (PRRSFREE PRRS subunit vaccine, Reber Genetics, Taiwan, Republic of China) under field conditions. The study was performed in three farms with endemic infections with both PRRS virus (PRRSV)-1 and PRRSV-2, a situation representative of most Korean farms. Pregnant sows were immunised intramuscularly with 2.0 ml of the PRRS subunit vaccine at 58 and 79 days of gestation (eight and five weeks antepartum) according to the manufacturer's recommendation. Vaccination did not result in any observed adverse reaction. Vaccinated sows exhibited a significant improvement in reproductive performance (reduction of abortions) and litter characteristics (increase of weaned pigs) compared with unvaccinated sows. Vaccinated sows had significantly (P<0.05) higher PRRSV ELISA sample/positive ratio and number of PRRSV-specific interferon-y- secreting cells compared with the unvaccinated control group. The results of this study demonstrate that the PRRS subunit vaccine can improve the reproductive performance of sows in farms with endemic PRRSV infection.</P>
Jeong, Jiwoon,Park, Changhoon,Oh, Taehwan,Park, Kee Hwan,Yang, Siyeon,Kang, Ikjae,Park, Su-Jin,Chae, Chanhee Elsevier 2018 Veterinary microbiology Vol.223 No.-
<P><B>Abstract</B></P> <P>We have evaluated the cross-protection of a modified-live virus (MLV) vaccine based on porcine reproductive and respiratory syndrome virus (PRRSV)-2, against a heterologous PRRSV-1 challenge in late term pregnancy gilts. Gilts were vaccinated 42 days prior to breeding and then challenged intranasally with PRRSV-1 at 93 days of gestation. No local or systemic adverse effects related to vaccination were observed in the vaccinated gilts throughout the study. Vaccination resulted in a longer gestation period, a higher number of live-born and weaned piglets, and a significant decrease in the number of stillborn piglets compared to the unvaccinated group. The PRRSV-2 MLV vaccine was also able to significantly reduce PRRSV-1 viremia. At the time of PRRSV-1 challenge, vaccinated gilts had significantly higher PRRSV-1 specific interferon-γ secreting cells but low neutralizing antibody titers against PRRSV-1 compared to unvaccinated gilts. This correlated with a reduction of PRRSV-1 viremia, indicating that cell-mediated rather than humoral immunity played a role in PRRSV-1 clearance from the blood. Fetal thymic tissues from vaccinated pregnant gilts had fewer PRRSV-1 positive cells compared to unvaccinated gilts. Taken together these results indicate that vaccination of gilts with PRRSV-2 MLV vaccine can provide cross-protection against PRRSV-1 challenge and improve reproductive performance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A PRRSV-2 MLV vaccine provided cross-protection against heterologous PRRSV-1 challenge. </LI> <LI> Vaccination of gilts with a PRRSV-2 MLV vaccine improved reproductive performance. </LI> <LI> Duration of immunity lasted at least 19 weeks. </LI> </UL> </P>
Yield Strength Prediction of UOE Pipes: From Forming to Flattening
Yi, Jiwoon,Kang, Soo-Chang,Koh, Hyun-Moo,Choo, Jinkyo F International Society of Offshore and Polar Engine 2018 International journal of offshore and polar engine Vol.28 No.2
<P>With the advent of higher steel grades for offshore pipelines and the reliance of the UOE forming process on trial and error, knowing the final yield strength of the pipe beforehand would be beneficial in terms of time and cost. However, predicting the yield strength of the UOE pipe constitutes a difficult task because of the alteration of the material properties throughout the forming process. Moreover, the yield strength is measured by tensile test executed on specimens obtained by flattening samples cut from the formed pipe, but this flattening process also alters the properties of the material. Accordingly, this study presents a 2-D finite element method (FEM) program considering both forming and flattening processes to predict the yield strength of the UOE pipe measured by tensile test. The results show that the simulation predicts the yield strength with good accuracy.</P>
Jeong, Jiwoon,Kim, Seeun,Park, Changhoon,Park, Kee Hwan,Kang, Ikjae,Park, Su-Jin,Chae, Chanhee BMJ Group Group Ltd 2018 The Veterinary record Vol.182 No.17
<P>This study evaluated porcine reproductive and respiratory syndrome virus (PRRSV)-2 modified live virus (MLV) vaccine against heterologous single and dual challenge of Korean PRRSV-1 and PRRSV-2. Pigs were administered PRRSV-2 MLV vaccine intramuscularly at 21 days of age and inoculated intranasally with both genotypes at 56 days of age. Vaccination of pigs with PRRSV-2 MLV vaccine resulted in reduction of viral loads of both PRRSV-1 and PRRSV-2 after heterologous single and dual challenge with PRRSV-1 and PRRSV-2. In addition, pigs vaccinated with PRRSV-2 MLV vaccine exhibited higher frequencies of PRRSV-1 and PRRSV-2 specific interferon-i secreting cells (IFN-gamma-SC) and showed a significant reduction in lung lesions and PRRSV nucleic acid within the lung lesions after single and dual challenge compared with unvaccinated challenged pigs. Taken together these results demonstrated that vaccination of pigs with PRRSV-2 is efficacious in protecting growing pigs from respiratory disease against heterologous single and dual PRRSV-1 and PRRSV-2 challenge.</P>