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      • KCI등재

        An Experimental Study on Seepage within Shale Fractures due to Confining Pressure and Temperature

        Jingping Wang,Haichun Ma,Peichao Feng,Qing Zhang,Jiazhong Qian,Xiaohui Tan,Lei Ma,Daoxiang Wu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.9

        Seepage of groundwater within rock fractures is widespread. The seepage conditions in the fractures can be affected by the stress and temperature conditions. Shale seepage conditions are a complicated coupling of stress and temperature. Experiments were carried out on shale samples containing three types of fractures: a single short fracture (type A), a single long fracture (type B), and symmetrical short fractures (type C). Three temperature conditions were set for type A. The coefficient C, which is defined as the ratio between the seepage pressure and the flow rate, is constant when the temperature effects are slight. Linear correlations between the coefficient C and the temperature were simulated. For type B, four confining pressures were applied using the confining pressure pump. As the confining pressure increases, the seepage pressure increases. The seepage pressure distribution is nonlinear when the flow rate increases to 6 ml/min under a confining pressure of 12 MPa. For type C, three temperature conditions with three confining pressure conditions were analyzed to determine the seepage pressure. The effects of the confining pressure on the seepage pressure are different from those of type B. Nonlinear curves occur under confining pressures of 3 MPa and 6 MPa at 50°C. The seepage pressure values at 70°C are smaller than those at 30°C and 50°C. The coefficient C contour is depicted for the experimental ranges of temperature and confining pressures. The small value region of coefficient C occurs at about 6 MPa and 50°C. The nonlinear increase in the seepage pressure in the fractures occurred when the confining pressure was larger for a single fracture and when the confining pressure was lower for double fractures.

      • KCI등재

        Two-Dimensional SPH Analysis of Seepage with Water Injection Process for Different Crack Morphologies

        Haichun Ma,Jingping Wang,Jiazhong Qian,Xiaohui Tan,Luwang Chen,Yaping Deng,Zhitang Lu,Lei Ma 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.5

        Crack seepage in nature involves natural and water injection flow, causing crack morphology in nature to be varied. Using the numerical simulation method of smoothed particle hydrodynamics (SPH), the natural free flow process in a crack was analyzed. With the interference of the initial velocity of the x = 0 particles, the other terminal particles were shifted, and the particles with initial velocities were reversed. For water injection simulations, ghost particles were set to block particles from overflowing, as particles subjected to injection water were mobilized more quickly than under free flow conditions. For rough cracks, particle magnitude was affected by the boundary shape, but overall particle velocity was influenced little, and the distribution of particles was sparse and densely spaced. For the branch crack simulation, overall particle seepage velocity decreased, but particles moved faster through the wider branch than through the narrower branch. SPH can simulate the seepage through crack networks and be used to analyze the effects of different crack geometries and physical properties.

      • KCI등재

        SET/PP2A signaling regulates macrophage positioning in hypoxic tumor regions by amplifying chemotactic responses

        Zhang Shaolong,Zhou Jingping,Shang Pengzhao,Zhao Guomeng,Wang Anlei,Mao Jinlei,Tao Yuhang,Chen Ziyi,Wang Xuehao,Guo Changying 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

        Tumor-associated macrophages (TAMs) are one of the main cellular components in the tumor microenvironment (TME). In many types of solid tumors, TAMs tend to accumulate in hypoxic areas and are intimately related to poor patient prognosis. However, the underlying mechanisms by which TAMs infiltrate hypoxic tumor regions remain unclear. In this study, we report that genetic deletion of SE translocation (SET) in myeloid cells inhibited the entry of TAMs into the hypoxic tumor region and abated their proangiogenic and immunosuppressive functions, ultimately inhibiting tumor growth. Mechanistically, in response to hypoxic tumor supernatant stimulation, SET in macrophages shuttled between the nucleus and cytoplasm via the PKC-CK2α signaling axis. Cytoplasmic retention of SET increased ERK and P38 signaling by inhibiting PP2A, which promoted TAM migration into the hypoxic area and polarization toward the M2 phenotype. Therefore, we conclude that SET modulates tumor immunity by acting as a key regulator of macrophage positioning and function in the tumor.

      • KCI등재

        Experimental and Theoretical Study of Seepage Models under Confining Pressure for A Single Rock Fracture

        Peng Zhou,Haichun Ma,Jingping Wang,Jiazhong Qian 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.5

        The engineering water inrush events were affected by the hydraulic characteristics of the fractures. In order to quantitatively study the seepage characteristics of the fractures, the experimental analysis of artificial fracture of shale was carried out under different confining pressure (22 MPa − 38 MPa) to explore the influence of confining pressure on seepage characteristics. Three theoretical constitutive formulas to describe the characteristics of seepage were proposed based on cubic law and fracture constitutive equation (Bandis model, Rong model, Sun model), and these theoretical constitutive formulas all had good fitting results to experiment results which indicated that the derived formulas are feasible. The parameters for the three models were compared, among which the Rong model was more suitable to describe the connection between (Q) and (Pc). Rong model and Sun model were highly descriptive to the relationship between (Pc) and (Ps). The formulas that based on three theoretical models can provide quantitative calculation for the influence of in-situ stress change on the seepage of fractures in engineering practice.

      • KCI등재

        Amino-Ended Hyperbranched Polyamide Modified SBA-15 as Support for Highly Efficient Cobalt Fischer-Tropsch Synthesis Catalyst

        Sufang Chen,Yanju Qiu,Xixi Xing,Cunwen Wang,Chengchao Liu,Yuhua Zhang,Jingping Hong,Jinlin Li,Daohong Zhang 한국고분자학회 2020 Macromolecular Research Vol.28 No.3

        Among the Fischer-Tropsch synthesis (FTS) catalysts, Cobalt catalysts are currently attracting a lot of research interests due to their high activity and high selectivity. But the dispersion and reducibility of cobalt catalysts with moderate interaction between cobalt and support are still a challenge. A novel amino-ended hyperbranched polyamide (AEHPA) was used to modify SBA-15 and then was applied as support for obtaining cobalt catalyst (15Co/SBA-15-N). The catalysts were characterized by XRD, TEM, XPS and H2-TPR techniques. The results showed that AEHPA doped mesoporous SBA-15 caused the generation of N species in the SBA-15 pore channels. The N-Co bonds resulted in the formation of highly-dispersed cobalt nanoparticles with uniform sizes inside the ordered mesopores of support. AEHPA doping was an effective way to modify the surface properties of the SBA-15 for immobilizing cobalt nanoparticles. Compared with the conventional 15Co/SBA-15 catalyst without doping AEHPA, the AEHPA doped 15Co/SBA-15-N catalyst showed improved cobalt dispersion and stabilized cobalt location, which led to much better reaction stability as well as C5+ selectivity.

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