Folate intake, Methylenetetrahydrofolate Reductase Polymorphisms in Association with the Prognosis of Esophageal Squamous Cell Carcinoma

Jing, Chen,Huang, Zhijie,Duan, Yuqin,Xiao, Xinrong,Zhang, Ru,Jiang, Jianqing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

Aim: An epidemiological study was conducted based on an esophageal cancer patient's cohort to investigate the association of folate intake and MTHFR C677T polymorphism with the prognosis of esophageal cancer in a Chinese population. Methods: 167 patients aged 37-75 years who had histological confirmed diagnosis of esophageal squamous cell cancer were collected from Jan. 2006 to Jan. 2008. MTHFR genotypes at the C677T site were analyzed by PCR-based RFLP methods, and the folate intake was computed by multiplying the food intake (in grams) and the folate content (per gram) of food in our questionnaire. Results: We found associations between the prognosis of esophageal cancer and smoking status, T and N stages. Individuals carrying the MTHFR 677CT and TT genotypes showed a shorter survival time than with the CC genotype, with adjusted HRs (95% CI) of 1.20 (0.56-2.15) and 2.29 (1.30-4.28), respectively. Similarly, those carrying MTHFR 677T allele had a 1.86-fold risk of death. A higher folate concentration showed a significant decreased risk of death, with an HR (95% CI) of 0.45 (0.18-0.87). Individuals with high folate intake and the MTHFR 677CC genotype showed a significant decreased risk of esophageal cancer (0.43, 0.25-0.89).Conclusion: Our findings supports the hypothesis that high folate intake and active MTHFR C677T polymorphism may exert protective roles in the prognosis of esophageal cancer in the Chinese population.

Study of Spaceborne W-band Millimeter Wave Radiometer

Jing, Li,Shengwei, Zhang,Maohua, Sun,Decai, Kong,Heguang, Liu,Jingshan, Jiang 대한원격탐사학회 2001 International Symposium on Remote Sensing Vol.17 No.1

The W-band millimeter wave radiometer has been studied under the support of Chinese Academy of Science (CAS) and it is successfully studied for the first time in China. Its technical index is suitable for the use in space. The main characteristics of the W-band millimeter wave radiometer are introduced in this paper.

Investigation on separation principle of vanadium and chromium among Fe2VO4-CaO-FeCr2O4 system: Simplify and simulate calcification roasting process of vanadium-chromium slag

Jing Wen,Tao Jiang,Hongyan Sun,Tangxia Yu,Ming Li,Yi Peng 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-

The competitive reaction of vanadium and chromium with calcium additives, along with the formationmechanism of calcium vanadate and calcium chromate are the central issue to the efficient separationand extraction of vanadium and chromium from vanadium-chromium slag (V-Cr slag) by calcificationroasting. In this study, Fe2VO4 and FeCr2O4 were synthesized to simulate the vanadium chromium spinelin V-Cr slag; then, the reaction mechanism of Fe2VO4-CaO-FeCr2O4 powder system was studied by XRD,SEM and leaching experiments. Results showed that calcium vanadate and calcium chromate are generatedafter roasting Fe2VO4-CaO system and FeCr2O4-CaO system individually. In Fe2VO4-CaO-FeCr2O4 system,as n(CaO)/n(V2O3) is 2, vanadium exists in the form of Ca2V2O7 while almost all Cr2O3 from thedecomposition of FeCr2O4 reacts with Fe2O3 to continuously form solid solution with more FeCr2O4 adding. After leaching, the addition of FeCr2O4 has no obvious effect on the leaching ratio of vanadium, andthe leaching ratio of chromium decrease with FeCr2O4 adding. Consequently, 94.03% of vanadium and0.15% of chromium are leached with n(CaO)/n(V2O3)/n(Cr2O3) of 2/1/1.03 at 900 C. When n(CaO)/n(V2O3) is 4, Fe2VO4 is oxidized and calcified gradually to form Ca2V2O7 and Ca3V2O8 with increasing roastingtemperature. A small amount of CaCrO4 is generated owing to the calcification of chromium, and mostchromium still exists in the form of solid solution. The reaction result of Cr2O3 and Fe2O3 is the superpositionof solid solution reactions with different degrees. Increasing the roasting temperature can significantlyreduce the chromium leaching ratio. All above would provide a theoretical support for thecalcification roasting process from V-Cr slag.

An Iterative Space Alternative Tiling Parallel Algorithm for 3D Finite Difference Stencil Computations

Jing Shen,Jilin Zhang,Jian Wan,Li Zhou,Ming Jiang 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6

Stencils are finite-difference algorithms for solving large-scale and high-dimension partial differential equations. Due to the data dependences among the iterative statements in Stencils, traditional Stencil computations are be executed serially, rather than in parallel. It’s challenging to design an effective and scalable Stencil parallelized method. To address the issue of 3D data space computing, we present a serial execution model based on multi-layers symmetric Stencil method and time skewing techniques. Within this model, the iteration space is divided to multiple tiles based on time skewing, where the executive process is ordered by the sequence of tiles, and the nodes in each individual tile can be swept repeatedly to improve the data locality. In addition, we propose a novel 3D iterative space alternate tiling Stencil parallel method, which subdivides the iteration space along high dimension, and changes the execution sequence of tiles to reduce the data dependency and communication cost, where the partial order of tiles is still guaranteed. Experimental results demonstrate our proposed alternative tiling parallel method achieves better parallel efficiency and scalability compared with the domain-decomposition methods.

Rapid Structural Improvement of CVD-Grown Multi-Walled Carbon Nanotubes by Drastic Thermite Reaction

Jiang Zhao,Jing Chen,Pengcheng Zhang,Haofeng Yu,Jie Chen 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.8

Multi-walled carbon nanotubes (MWCNTs) produced by chemical vapor deposition (CVD) are the most common commercial products at extremely low price in the market. However, due to the inherent drawbacks of CVD surroundings at temperature below ~ 1000℃, CVD-grown nanotubes usually have very disordered structure, resulting in most of their properties being much below expectations. Herein, we present a simple and energy-efficient method for improving rapidly the structure of CVD-grown MWCNTs via a drastic thermite reaction process. Direct observations from scan electron microscope (SEM) and transmission electron microscope (TEM) images, decrease of ID/IG ratios in Raman spectra, increase of the starting oxidation temperatures observed in thermogravimetric analysis (TGA), decrease of the volumetric electrical resistivity and decrease of the turn-on electric fields from 3.64 to 2.88 V/µm in field emission measurements suggest that the graphitization of MWCNTs can be effectively enhanced and the structure of nanotubes becomes more ordered after the drastic thermite reaction process.

Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbens

Jing-Guang Lu,Yingwei Wang,Ming-Rong Yang,Cai-Yun Wang,Jieru Meng,Jiazheng Liu,Zifeng Yang,Kongsong Wu,Li-Ping Bai,Guo-Yuan Zhu,Zhi-Hong Jiang 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.9

(±)-Decumicorine A ( 1 ) and (±)- epi -decumicorine A ( 2 ), two pairs of enantiomeric isoquinoline alkaloids featuring a novel phenylpropanoid-conjugated protoberberine skeleton, were isolated and purifi ed from the rhizomes of Corydalis decumbens . The separation of (±)- 1 and (±)- 2 was achieved by chiral HPLC to produce four optically pure enantiomers. The structures and absolute confi gurations of compounds (−)- 1 , (+)- 1 , (−)- 2 , and (+)- 2 were elucidated by spectroscopic analysis, ECD calculations, and X-ray crystallographic analyses. The two racemates were generated from a Diels-Alder [4 + 2] cycloaddition between jatrorrhizine and ferulic acid in the proposed biosynthetic pathways, which were fully verifi ed by a biomimetic synthesis. Moreover, compound (+)- 1 exhibited an antiviral entry eff ect on SARS-CoV-2 pseudovirus by blocking spike binding to the ACE2 receptor on HEK-293T-ACE2 h host cells.

Antimalarial Effects of Areca catechu L.

Jiang, Jing-Hua,Jung, Suk-Yul,Kim, Youn-Chul,Shin, Sae-Ron,Yu, Seung-Taek,Park, Hyun The Physiological Society of Korean Medicine and T 2009 동의생리병리학회지 Vol.23 No.2

The emergence and spread of drug-resistant malaria parasites is a serious public health problem in the tropical world. Useful antimalarial drugs such as chloroquine have resistance in the world now. Moreover, other antimalarialdrugs such as mefloquine, halofantrine, atovaquone, proguanil, artemether and lumefantrine retain efficacy but have limitations, one of which is their high cost. New antimalarial drugs are clearly needed now. Cytotoxicity assay and susceptibility assay were performed for the selectivity of herb extracts in vitro. On the basis of high selectivity, 4-day suppressive test and survival test were progressed in Plasmodium berghei-infected mice. The selectivity of Areca catechu L. (ACL) and butanol extract of ACL (ACL-BuOH extract) were 3.4 and 3.0 in vitro, respectively. Moreover in vivo, 4-day suppressive test showed 39.1 % inhibition effect after treated with 150 mg/kg/day ACL-BuOH to P. berghei-infected mice. Survival test also showed 60% survival rate with ACL-BuOH-treated group while all other group mice died. In this study, ACL and ACL-BuOH were investigated for antimalarial activity in vitro and in vivo and they showed a potent antimalarial activity. In particular,ACL-BuOH could specifically lead higher survival rate of mice in vivo. Therefore ACL-BuOH would be a candidate of antimalarial drugs.

Preparation and Evaluation of Pectin-based Colon-specific Pulsatile Capsule In Vitro and In Vivo

Jing Liu,Liang-ke Zhang,Yuntao Jia,Wenjing Hu,Jing-qing Zhang,Huiming Jiang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11

The purpose of this study was to develop and evaluate a colon-specific, pulsatile drug delivery system, which consists of an impermeable capsule body filled with a 5-aminosalicylic acid rapid-disintegrating tablet and a pectin-based erodible plug placed in the opening of the capsule body. To obtain an appropriate gel-forming ability and suitable lag time for the colon-specific drug delivery, high-methoxy pectin (HM-pectin) was formulated with lactose and lowmethoxy pectin (LM-pectin) with HPMC to prepare the plug tablet. In order to evaluate the lag time, prior to the rapid drug release, both the formulation of the plug tablet and in vitro release medium were studied. The lag time prior to the rapid drug release was mainly determined by the HM-pectin/lactose or LM-pectin/HPMC ratio. The addition of pectinase or rat cecal content into the release medium shortened the lag time significantly, which predicted the probable enzyme sensitivity of pectin plug tablet. In vivo studies showed that the plasma concentration of drug can only be detected 6 h after oral administration of the pulsatile capsule, which indirectly proved the colon-specific characteristics. These results show that the pulsatile capsule may have the therapeutic action for colon-specific drug delivery.

Does HBV Infection Increase Risk of Endometrial Carcinoma?

Jiang, Xue-Feng,Tang, Qiong-Lan,Zou, Yuan,Xu, Ling,Zeng, Hua,Chi, Cong,Jiang, Jing-Ru,Zhang, Bin-Zhong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Objective: Connections between chronic inflammation and tumor development and progression are now generally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, but whether endometrial carcinoma (EC) is included has not been reported. Methods: We analyzed HBV serum marker status in 398 patients with endometrial cancer, comparing them to 788 control women undergoing health examination. Results: The total prevalence of HBsAg tested positive in cancer group was significantly higher than the control group (12.8% vs 6.0%, P=0.001), while positive HBsAb was significantly lower (41.2% vs 68.5%, P=0.001). Hepatitis B carriers in endometrial cancer group were also more frequent than in the control group (9.3% vs 5.5%, P=0.013). Interestingly, in the endometrial cancer group, 147 cases were HBV serum marker negative, which was also higher than in the control group (36.9% vs 15.6%, P=0.001). Conclusion: There may be a correlation between HBV infection and endometrial carcinoma.

The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo

Jiang, Wei,Huang, Yong,Wang, Jing-Peng,Yu, Xiao-Yun,Zhang, Lin-Yi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Background: Artesunate, extracted from Artemisia annua, has been proven to have anti-cancer potential. Allicin, diallyl thiosulfinate, the main biologically active compound derived from garlic, is also of interest in cancer treatment research. This object of this report was to document synergistic effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo. Methods: After treatment with artesunate and allicin at various concentrations, the viability of osteosarcoma cells was analyzed by MTT method, with assessment of invasion and motility, colony formation and apoptosis. Western Blotting was performed to determine the expression of caspase-3/9, and activity was also detected after drug treatment. Moreover, in a nude mouse model established with orthotopic xenograft tumors, tumor weight and volume were monitored after drug administration via the intraperitoneal (i.p.) route. Results: The viability of osteosarcoma cells in the combination group was significantly decreased in a concentration and time dependent manner; moreover, invasion, motility and colony formation ability were significantly suppressed and the apoptotic rate was significantly increased through caspase-3/9 expression and activity enhancement in the combination group. Furthermore, suppression of tumor growth was evident in vivo. Conclusion: Our results indicated that artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis.