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- 저자 : Jingfa Zhang (검색결과 3 건)
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Zhao Zhenzhen,Zhang Yumeng,Zhang Chaoyang,Zhang Jingting,Luo Xueting,Qiu Qinghua,Luo Dawei,Zhang Jingfa 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Subretinal fibrosis remains a major obstacle to the management of neovascular age-related macular degeneration. Choroidal pericytes were found to be a significant source of subretinal fibrosis, but the underlying mechanisms of pericyte-myofibroblast transition (PMT) remain largely unknown. The goal of this study was to explore the role and potential mechanisms by which PMT contributes to subretinal fibrosis. Choroidal neovascularization (CNV) was induced by laser photocoagulation in transgenic mice with the collagen1α1-green fluorescent protein (Col1α1-GFP) reporter, and recombinant adeno-associated virus 2 (rAAV2)-mediated TGF-β2 (rAAV2-TGF-β2) was administered intravitreally to further induce PMT. Primary mouse choroidal GFP-positive pericytes were treated with TGF-β2 in combination with siRNAs targeting Smad2/3, the Akt inhibitor MK2206 or the mTOR inhibitor rapamycin to examine cell proliferation, migration, and differentiation into myofibroblasts. The involvement of the Akt/mTOR pathway in PMT in subretinal fibrosis was further investigated in vivo. Intraocular TGF-β2 overexpression induced GFP-positive pericyte infiltration and PMT in subretinal fibrosis, which was mimicked in vitro. Knockdown of Smad2/3 or inhibition of Akt/mTOR decreased cell proliferation, PMT and migration in primary mouse pericytes. Combined inhibition of Smad2/3 and mTOR showed synergistic effects on attenuating α-smooth muscle actin (α-SMA) expression and cell proliferation. In mice with laser-induced CNV, the administration of the Akt/mTOR inhibitors suppressed pericyte proliferation and alleviated the severity of subretinal fibrosis. Our results showed that PMT plays a pivotal role in subretinal fibrosis, which was induced by TGF-β2 through the Smad2/3 and Akt/mTOR pathways. Thus, inhibiting PMT may be a novel strategy for the treatment of subretinal fibrosis.
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Research on Seismic Scenario Simulation Method in Urban System
Jianfei Wang(王建飞,),Huiyan Wang(王慧彦),Jingfa Zhang(张,景发,),Qiang Li(李强) 위기관리 이론과 실천 2020 Disastronomy Vol.3 No.1
Earthquake was called The Head of Catastrophe in many countries because of its sudden, wide-ranging, and severe loss characteristics. Due to the density of people, economy and buildings in cities, the development and evolution of the earthquake disaster chain presents more complex and varied systemic features. There have been many studies of seismic scenarios, most of which focus on the simulation of the disaster itself, but little attention has been paid to the disaster mechanism and its control methods within the urban system. In the view of urban systemic characteristics, this paper analyzes the evolution and development of earthquake disaster scenarios in urban systems. Based on the interaction of various elements of the urban system, the content system of urban seismic scenario research is clarified. Finally, considering the dual scenarios of disaster and response, an urban seismic scenario construction method is proposed which covers risk assessment, disaster simulation, task and capability matching, emergency preparedness plan. We hope that this research can develop the urban earthquake scenario research and provide reference for the earthquake disaster reduction.
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Wenliang Jiang,Tian Tian,Yan Chen,Xin Wang,Jingfa Zhang 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.5
The Tan-Lu fault zone (TLFZ) is one of the most important active faults in the eastern Chinese mainland, and the seismic activity of the Su-Lu segment is most prominent. The fault structures of the Su-Lu section are very complex and intersect with many other NW-striking and NE-striking fault zones, resulting in the extreme complexity of the crustal structure in this area. In this study, Bouguer gravity and aeromagnetic data are used to invert the crustal structures surrounding the Su-Lu segment and to construct a three-dimensional model. Our results indicate that the TLFZ presents obvious high anomalies in gravity and aeromagnetic fields, cuts through the Moho interface and acts as an upwelling passage for high-density materials from the uppermost mantle and asthenosphere. The gravity and aeromagnetic anomalies are greatly influenced by the crustal structures. Both the Moho and Curie interfaces are characterized by substantial undulations. The NW-striking and NE-striking faults intersect the TLFZ with different relations—for example, the Wuxi-Suqian fault and Cangshan-Nishan fault cut off the TLFZ with distinct gravity and aeromagnetic anomalies, and the Xintai-Mengyin fault and Mengshan piedmont fault cut off the western part of the TLFZ. In addition, most faults cut to the middle crust, and the lower crust is ductilely deformed because of magmatic underplating, reforming, remelting and thinning of the eastern North China block. Most earthquakes occur in the northern part of the Su-Lu segment, where magmatic activity is intense.
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