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Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease
Kim, YongHwan,Jin, Hye Jin,Heo, Jinbeom,Ju, Hyein,Lee, Hye-Yeon,Kim, Sujin,Lee, Seungun,Lim, Jisun,Jeong, Sang Young,Kwon, JiHye,Kim, Miyeon,Choi, Soo Jin,Oh, Wonil,Yang, Yoon Sun,Hwang, Hyun Ho,Yu, H Nature Publishing Group UK 2018 Leukemia Vol.32 No.12
<P>Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs primed with Hypoxia and Calcium ions (SHC-MSCs) exhibit enhanced stemness and immunomodulatory functions for treating allogeneic conflicts. Compared with naïve cultured human umbilical cord blood-derived MSCs, SHC-MSCs were resistant to passage-dependent senescence mediated via the monocyte chemoattractant protein-1 and p53/p21 cascade and secreted large amounts of pro-angiogenic and immunomodulatory factors, resulting in suppression of T-cell proliferation. SHC-MSCs showed DNA demethylation in pluripotency, germline, and imprinted genes similarly to very small embryonic-like stem cells, suggesting a potential mutual relationship. Genome-wide DNA methylome and transcriptome analyses indicated that genes related to immune modulation, cell adhesion, and the cell cycle were up-regulated in SHC-MSCs. Particularly, polo-like kinase-1 (<I>PLK1</I>), zinc-finger protein-143, dehydrogenase/reductase-3, and friend-of-GATA2 play a key role in the beneficial effects of SHC-MSCs. Administration of SHC-MSCs or <I>PLK1</I>-overexpressing MSCs significantly ameliorated symptoms of graft-versus-host disease (GVHD) in a humanized mouse model, resulting in significantly improved survival, less weight loss, and reduced histopathologic injuries in GVHD target organs compared with naïve MSC-infused mice. Collectively, our findings suggest that SHC-MSCs can improve the clinical treatment of allogeneic conflicts, including GVHD.</P>
김진범(Jinbeom Kim),나석주(Suckjoo Na),장원석(Wonseok Chang),김재구(Jaegoo Kim),최무진(Moojin Choi) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.11
In this work, a study on the energy distribution of short pulses at near field was performed for nano-scale processing. The finite-difference-time-domain (FDTD) method was employed to simulate the energy distribution in near field. The simulation was executed for NSOM tip with aperture and femto-second laser (λ=800㎚). The simulation results show that the energy distribution is a function of the tapered angle, the diameter of the aperture and the coating material of the tip. The intensity of laser energy behind the aperture decreases exponentially with increasing distance from the aperture, while the full width at half maximum is also expanded.
김진범(Jinbeom Kim),황석환(Sekhwan Hwang),정진철(Jinchul Chung) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
The HRSG is the equipment to recover energy from flue gas of gas turbine. The inside components of HRSG are faced with high speed and temperature flue gas discharged from the gas turbine. HRSG bumpers are installed to protect heat exchange tube bank from flue gas. However, bumpers are damaged by flow induced vibration of flue gas in some cases. In this study, we analyzed flow behaviors near HRSG bumper through computational fluid dynamics with LES, and then extracted PSD data from CFD results. Consequentially, the life of HRSG bumper was predicted through using these PSD data on bumper.
김진범 ( Jinbeom Kim ),송문빈 ( Moonvin Song ),정연모 ( Yunmo Chung ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.2
IPsec(Internet Protocol Security protocol)에서는 기본적으로 4개의 암호 알고리즘(3-DES, AES, MD5, SHA-1)을 사용하고 있다. 본 논문은 4개의 암호 알고리즘을 효율적으로 통합 및 하드웨어로 설계하였으며 검증하였다. 그 결과 알고리즘을 각각 합친 경우보다 하드웨어에서의 크기를 줄일 수 있다.
김승환(Seunghwan Kim),이진범(Jinbeom Lee),이진용(Jinyong Lee),김영록(Younglok Kim) 한국통신학회 2008 韓國通信學會論文誌 Vol.33 No.6A
유럽형 지상파 디지털 방송 표준인 DVB-T 시스템에서는 OFDM방식을 사용하여 신호를 전송하며, 주파수 선택적 페이딩 환경과 충격 잡음 채널에서도 향상된 성능을 제공 할 수 있다. 그러나 이동성이 가정된 시변 채널에서는 도플러 확산의 영향 때문에 한 OFDM 심볼 안에 존재하는 부반송파 사이의 직교성의 파괴, 즉 inter-carrier interference(ICI)가 발생하여 심각한 성능 열화가 발생한다. 본 논문에서는 시간 및 주파수 축에서 채널의 특성과 ICI를 분석하고, OFDM시스템에서 구현이 간단한 LS 알고리즘과 이를 이용한 잡음 및 ICI 감쇄 기법을 사용한 LS 방식을 단말기의 속도에 따라 선택하여 사용하는 적응형 채널 추정 방식을 제안한다. 단말기의 속도를 추정하는 방법을 제안하여 COST207의 TU6 채널 모델을 적용한 시뮬레이션을 통하여 그 동작을 확인하였다. 또한 속도 추정을 위한 연산을 최소화한 알고리즘을 제안하여 하드웨어의 증가를 무시할 정도로 줄였다. 제안된 적응형 채널 추정 알고리즘은 속도가 약 70 ㎞/h 이하인 경우에 잡음 및 ICI 감쇄기법을 위한 하드웨어를 동작시키지 않음으로서 전력의 소모가 현저하게 줄어든다. In digital video broadcasting-terrestrial (DVB-T), which is the European digital terrestrial television standard, the orthogonal frequency division multiplexing (OFDM) has been adopted for signal transmission. The main reasons using OFDM are to increase the robustness against the frequency selective fading and impulse noise, and to use available bandwidth efficiently. However, channel variation within an OFDM symbol destroys orthogonality between subcarriers, resulting in inter-carrier interference (ICI), which increases an error floor in proportional to maximum Doppler spread. This paper provides an ICI analysis in both time and frequency domains while existing literatures analyze the ICI effects mainly in frequency domain and proposes the algorithms that estimate the channel impulse response and channel variation using least square (LS) algorithm which is the most simple channel estimation technique. And we propose adaptive channel estimation algorithm that estimates the velocity of terminals. The simulation results show that proposed algorithm has similar performance with about 1.5% computational complexity of noise and ICI reduction LS algorithm in low speed environments.