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FACILE SYNTHESIS OF HYDROXYLAPATITE NANOSTRUCTURES WITH VARIOUS MORPHOLOGIES
JIN-KU LIU,XIAO-JUN HU,XIAO-YAN QIN,JIA HUANG,YI YI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2009 NANO Vol.4 No.3
The hydroxylapatite nanostructures with different morphologies have been synthesized by a facile solution approach. The samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) technologies, and Fourier transforms infrared spectroscopy (FT-IR). The control mechanism of the hydroxylapatite with various morphologies nanostructures was investigated. Some practical experimental conclusions could be obtained, which were expected to have potential values in crystal engineering research and practical applications.
Assembling Synthesis of Barium Chromate Nano-superstructures Using Eggshell Membrane as Template
Liu, Jin-Ku,Wu, Qing-Sheng,Ding, Ya-Ping,Yi, Yu Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.12
The branch-like, feather-like $BaCrO_4$ nano-superstructures were synthesized with bioactive eggshell membrane as directing and assembly template. Studies on the two products revealed that they formed through the self-assembly of nanoparticles, and that the optical properties of the products were different from $BaCrO_4$ bulk materials.
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Lee, Jin-Ku,Liu, Zhaoqi,Sa, Jason K.,Shin, Sang,Wang, Jiguang,Bordyuh, Mykola,Cho, Hee Jin,Elliott, Oliver,Chu, Timothy,Choi, Seung Won,Rosenbloom, Daniel I. S.,Lee, In-Hee,Shin, Yong Jae,Kang, Hyun J Nature Pub. Co 2018 Nature genetics Vol.50 No.10
Liu, Ying Dan,Quan, Xuemei,Hwang, Bora,Kwon, Yong Ku,Choi, Hyoung Jin American Chemical Society 2014 Langmuir Vol.30 No.7
<P>Monodisperse core–shell-structured poly(styrene-<I>co</I>-butyl acrylate-<I>co</I>-[2-(methacryloxy)ethyl] trimethylammonium chloride)/silica (PSBM/SiO<SUB>2</SUB>) nanoparticles were applied as new electrorheological (ER) materials in which the particles were dispersed in an insulating oil. These nanoparticles were prepared by the consecutive precipitation of cetyltrimethylammonium bromide and negatively charged tetraethylorthosilicate onto the cationic surfaces of PSBM colloidal particles. The successful deposition of the shell phase of the particles and their morphology was examined by transmission and scanning electron microscopy. Their ER properties were studied with a rotational rheometer under different shear modes: controlled shear rate, steady shear under constant shear rate, and creep test. The silica shell allowed the PSBM/SiO<SUB>2</SUB> particles to exhibit typical ER performance under an applied electric field. The dielectric spectra of the PSBM/SiO<SUB>2</SUB>-based ER fluid were also recorded using an LCR meter, which was correlated to the ER performance of the ER fluid.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2014/langd5.2014.30.issue-7/la4050072/production/images/medium/la-2013-050072_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la4050072'>ACS Electronic Supporting Info</A></P>
Spatiotemporal genomic architecture informs precision oncology in glioblastoma
Lee, Jin-Ku,Wang, Jiguang,Sa, Jason K,Ladewig, Erik,Lee, Hae-Ock,Lee, In-Hee,Kang, Hyun Ju,Rosenbloom, Daniel S,Camara, Pablo G,Liu, Zhaoqi,van Nieuwenhuizen, Patrick,Jung, Sang Won,Choi, Seung Won,Ki Nature Pub. Co 2017 Nature genetics Vol.49 No.4
<P>Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies1-5. However, this proposition is complicated by spatial and temporal heterogeneity6-14. Here we study genomic and expression profiles across 127 multisector or longitudinal specimens from 52 individuals with glioblastoma (GBM). Using bulk and single-cell data, we find that samples from the same tumor mass share genomic and expression signatures, whereas geographically separated, multifocal tumors and/or long-term recurrent tumors are seeded from different clones. Chemical screening of patient-derived glioma cells (PDCs) shows that therapeutic response is associated with genetic similarity, and multifocal tumors that are enriched with PIK3CA mutations have a heterogeneous drug-response pattern. We show that targeting truncal events is more efficacious than targeting private events in reducing the tumor burden. In summary, this work demonstrates that evolutionary inference from integrated genomic analysis in multisector biopsies can inform targeted therapeutic interventions for patients with GBM.</P>
CHANG LIU,HONG-ZHEN XIE,QIN TONG,JIAN-DONG WANG,JIN-KU LIU,XIAO-HONG YANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.6
The zinc phosphate nanocrystals were synthesized by the ultrasonic – hydrothermal synergisticroute. The ultrasonic – hydrothermal synergistic route can not only decrease the size of the zincphosphate material, but also improve the crystallinity of the product. The transmission electronmicroscopy (TEM) image showed that the needle-like zinc phosphate product was 200 – 300 nmin length and 70 – 80 nm in width. The anti-corrosion tests revealed that the salt atmosphere-resistant time about 1056 h was longer than 768 h common zinc phosphate materials in themarket. The mechanisms of ultrasonic – hydrothermal synergistic route and anti-corrosion werediscussed.
FACILE SYNTHESIS OF COPPER NANOPARTICLE CHAINS
YI LU,JIN-KU LIU,XIAO-JUN HU,JIN MU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.1
The copper nanoparticle chains have been synthesized through a self-assembly process with sodium polymethacylic acid as the template. The resulted nanoparticle chains were 0.8–1.5 μm long, and the composed nanoparticles were about 30 nm in diameter. The self-assembly formation mechanism has been proposed.
Kim, Yong Jin,Ku, Seung-Yup,Kim, Yoon Young,Liu, Hung Ching,Chi, Sung Wook,Kim, Seok Hyun,Choi, Young Min,Kim, Jung Gu,Moon, Shin Yong Oxford University Press 2013 Human reproduction Vol.28 No.11
<P><B>STUDY QUESTION</B></P><P>Do microRNAs (miRNAs) in granulosa cells (GCs) affect oocyte maturation during ovarian follicle development?</P><P><B>SUMMARY ANSWER</B></P><P>Sophisticated regulation by miRNAs in ovarian GCs may improve oocyte maturation efficiency during ovarian follicle development.</P><P><B>WHAT IS KNOWN ALREADY</B></P><P>The meiotic competence of oocytes depends on the follicle's potential to undergo appropriate maturation and is an important factor in infertility therapies such as IVF. The exact function of the GCs during follicular development remains unknown.</P><P><B>STUDY DESIGN, SIZE, DURATION</B></P><P>After <I>in vitro</I> maturation (IVM) and ovulation induction of isolated ovarian pre-antral follicles from 12-day-old female C57BL6 mice (<I>n</I> = 40), miRNA expression in the GCs was compared according to the maturity of the oocyte (metaphase I (MI) versus metaphase II (MII)). The miRNAs, which showed notable different expression, were modulated by transfection during IVM of follicles.</P><P><B>MATERIALS, SETTING, METHODS</B></P><P>miRNA expression and candidate target gene expression in GCs of isolated murine ovarian pre-antral follicles were evaluated by real-time PCR after IVM. miR mimics and -inhibitors for selected miRNAs were transfected into the <I>in vitro</I>-maturated follicles, and ovulation, oocyte maturation and fertilization rates were compared. Candidate target gene expressions in GC were evaluated by quantitative PCR and immunohistochemistry using confocal microscopy.</P><P><B>MAIN RESULTS AND THE ROLE OF CHANCE</B></P><P>The relative expression of mmu-let-7b (0.78 ± 0.10, <I>P</I> = 0.016), mmu-let-7c (0.78 ± 0.12, <I>P</I> = 0.029), mmu-miR-27a (0.57 ± 0.18, <I>P</I> = 0.016) and mmu-miR-322 (0.59 ± 0.14, <I>P</I> = 0.008) was significantly lower in the GCs of follicles containing MII oocytes compared with those of MI oocytes. Transfection with a mmu-miR-27a-mimic sequence decreased the oocyte maturation rate compared with that for the control (9.4 versus 18.9%, <I>P</I> = 0.042), and transfection with mmu-let-7c-, mmu-miR-27a- and mmu-miR-322-inhibitor sequences increased the oocyte maturation rate by 1.5- to 2.0-folds compared with that for the control (40.6, 31.6, and 30.5%versus 18.9%, <I>P</I> < 0.001, <I>P</I> = 0.013, <I>P</I> = 0.021, respectively). The expression of IGFBP-2 was higher in GCs of MII than in the GCs of MI, and higher in miR-inhibitor transfection groups than in miR-mimic transfection groups and controls.</P><P><B>LIMITATIONS, REASONS FOR CAUTION</B></P><P>An <I>in vitro</I> model was used in lieu of an <I>in vivo</I> model because of the ease of performing miRNA transfection in cell culture. However, studies have shown similarities and differences in <I>in vivo</I> versus <I>in vitro</I> cultured follicles. The findings of the present study need to be confirmed using <I>in vivo</I> maturation models and extended to evaluate developmental competence.</P><P><B>WIDER IMPLICATIONS OF THE FINDINGS</B></P><P>Our findings suggest that sophisticated miRNA regulation in GCs may improve oocyte maturation efficiency during ovarian follicle development.</P><P><B>STUDY FUNDING/COMPETING INTEREST(S)</B></P><P>This work was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A111539). None of the authors has any conflicts of interest to declare.</P>