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- 저자 : Jigang Chen (검색결과 2 건)
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Chen Wenjia,Ma Zhaochen,Yu Lingxiang,MAO Xia,Ma Nan,Guo Xiaodong,Yin Xiaoli,Jiang Funeng,Wang Qian,Wang Jigang,Fang Mingliang,Lin Na,Zhang Yanqiong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma (HCC). Glucosylceramidase (GBA) is required for autophagic degradation. Whether ART regulates autophagic flux by targeting GBA in HCC remains to be defined. Herein, our data demonstrated that the dramatic overexpression of GBA was significantly associated with aggressive progression and short overall survival times in HCC. Subsequent experiments revealed an association between autophagic activity and GBA expression in clinical HCC samples, tumor tissues from a rat model of inflammation-induced HCC and an orthotopic mouse model, and human HCC cell lines. Interestingly, probe labeling identified GBA as an ART target, which was further verified by both a glutathione-S-transferase pulldown assay and surface plasmon resonance analysis. The elevated protein expression of LC3B, the increased numbers of GFP-LC3B puncta and double-membrane vacuoles, and the enhanced expression of SQSTM1/p62 indicated that the degradation of autophagosomes in HCC cells was inhibited by ART treatment. Both the in vitro and in vivo data revealed that autophagosome accumulation through targeting of GBA was responsible for the anti-HCC effects of ART. In summary, this preclinical study identified GBA as one of the direct targets of ART, which may have promising potential to inhibit lysosomal autophagy for HCC therapy.
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Yahong Xue,Jigang Chen,Xin Shi,Jichuan Yao,Junting Luo 한국섬유공학회 2018 Fibers and polymers Vol.19 No.3
A new parameterized finite element model was established for self-lubricating fabric liners in different weaving patterns. This model precisely simulated the spatial configuration of woven yarns with consideration of the cross-section deformation as well as the anisotropic material characteristics of yarns by converting the principal material direction along the yarn-path. Moreover, a set of simple and universal periodic boundary equations was proposed to solve the problem of the overabundance restriction in the boundary surfaces. To verify the validation of the finite element method proposed in this paper, an experimental prediction on elastic constants of self-lubricating fabric liners was carried out. The results indicate that the finite element model can successfully predict the macro mechanical properties of self-lubricating fabric liners with periodical structures. Based on the finite element model, the distributions of stress and strain, as well as the effects of weaving type and weaving density on the elastic modulus of fabric liners were investigated in details.
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