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- 저자 : Jiannan Wu (검색결과 2 건)
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Jianxin He,Jiannan Lu,Liang Liu,Wu Yang,Haihua Yang,Pengpeng Chen,Xinyu Ding 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.8
The primary contribution of this paper is to identify the optimal cross-section size and span diameter for large-grained hydraulic asphalt concrete materials in trabecular bending tests. First, three-point bending tests were conducted on asphalt concrete with maximum aggregate sizes of 19 mm (Dmax = 19 mm), 26.5 mm, and 31.5 mm, using six distinct cross-section sizes and span diameters. These experiments served to analyze the influence of varying cross-section sizes and span diameters on the mechanical properties of the materials. Secondly, the Image-Pro Plus (IPP) software was utilized to analyze and confirm the cross-sectional areas of the chosen samples. Then, by considering the optimal cross-section size and span diameter, the impact of temperature on the flexural characteristics of asphalt concrete with a maximum aggregate size of 31.5 mm was explored. This investigation enabled the proposal of a temperature cut-off interval governing the transformation of large-grained asphalt concrete from brittle to plastic damage. The validity of the experimental data was substantiated through image analysis, providing a benchmark for the testing methodology of the flexural performance of large-grained hydraulic asphalt concrete aggregate.
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Qiannan Guo,Runyao Wen,Bin Shao,Yudong Li,Xin Jin,Heran Deng,Jiannan Wu,Fengxi Su,Fengyan Yu 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2
Purpose: The long non-coding RNA H19, a conservatively imprinted gene, acts as a molecular sponge for the let-7 family, which has been identified as a set of tumor suppressors. However, the combined prognostic value of H19 and let-7a signature in breast cancer patients remains unclear. Methods: In this research we assessed the prognostic value of the combined H19 and let-7a signature in breast cancer patients by retrospectively reviewing that data of 79 patients who underwent neoadjuvant chemotherapy; we also investigated the expression and function of H19 in breast cancer cell lines in vitro. Survival data were calculated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate survival analyses were conducted using the Cox proportional hazards regression method. As determined using X-tile, the optimal cutoff value for the risk score to assess progression-free survival (PFS) based on the combined signature was –0.1. Results: Patients with an overall positive treatment response had higher let-7a and lower H19 levels. In addition, let-7a expression was negatively correlated with H19 expression. Patients with a risk score of >–0.1 had shorter overall survival and PFS. In vitro data showed that chemoresistant cell lines exhibit higher H19 and lower let-7a levels and knockdown H19 restores paclitaxel sensitivity. Conclusion: Our results suggest that the combined let-7a and H19 signature is a novel prognostic factor for breast cancer patients treated with neoadjuvant chemotherapy.
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