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RISS 인기검색어
- 검색키워드
- 저자 : Jianjian Zhao (검색결과 3 건)
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Jianjian Zhang,Shiteng Suo,Guiqin Liu,Shan Zhang,Zizhou Zhao,Jianrong Xu,Guangyu Wu 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.5
Objective: To compare various models of diffusion-weighted imaging including monoexponential apparent diffusion coefficient (ADC), biexponential (fast diffusion coefficient [Df], slow diffusion coefficient [Ds], and fraction of fast diffusion), stretched-exponential (distributed diffusion coefficient and anomalous exponent term [α]), and kurtosis (mean diffusivity and mean kurtosis [MK]) models in the differentiation of renal solid masses. Materials and Methods: A total of 81 patients (56 men and 25 women; mean age, 57 years; age range, 30–69 years) with 18 benign and 63 malignant lesions were imaged using 3T diffusion-weighted MRI. Diffusion model selection was investigated in each lesion using the Akaike information criteria. Mann–Whitney U test and receiver operating characteristic (ROC) analysis were used for statistical evaluations. Results: Goodness-of-fit analysis showed that the stretched-exponential model had the highest voxel percentages in benign and malignant lesions (90.7% and 51.4%, respectively). ADC, Ds, and MK showed significant differences between benign and malignant lesions (p < 0.05) and between low- and high-grade clear cell renal cell carcinoma (ccRCC) (p < 0.05). α was significantly lower in the benign group than in the malignant group (p < 0.05). All diffusion measures showed significant differences between ccRCC and non-ccRCC (p < 0.05) except Df and α (p = 0.143 and 0.112, respectively). α showed the highest diagnostic accuracy in differentiating benign and malignant lesions with an area under the ROC curve of 0.923, but none of the parameters from these advanced models revealed significantly better performance over ADC in discriminating subtypes or grades of renal cell carcinoma (RCC) (p > 0.05). Conclusion: Compared with conventional diffusion parameters, α may provide additional information for differentiating benign and malignant renal masses, while ADC remains the most valuable parameter for differentiation of RCC subtypes and for ccRCC grading.
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Sang Xuehan,Zhao Xiuhong,Yan Lianqi,Jin Xing,Wang Xin,Wang Jianjian,Yin Zhenglu,Zhang Yuxin,Meng Zhaoxiang 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3
BACKGROUND: Intra-articular injection is a classic strategy for the treatment of early osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited benefits for alleviating OA. Exosomes, an important type of extracellular nanovesicle, show great potential for suppressing cartilage destruction in OA to replace drugs and stem cellbased administration. METHODS: In this study, we developed a thermosensitive, injectable hydrogel by in situ crosslinking of Pluronic F-127 and hyaluronic acid, which can be used as a slow-release carrier to durably retain primary chondrocyte-derived exosomes at damaged cartilage sites to effectively magnify their reparative effect. RESULTS: It was found that the hydrogel can sustainedly release exosomes, positively regulate chondrocytes on the proliferation, migration and differentiation, as well as efficiently induce polarization of M1 to M2 macrophages. Intraarticular injection of this exosomes-incorporated hydrogel significantly prevented cartilage destruction by promoting cartilage matrix formation. This strategy also displayed a regenerative immune phenotype characterized by a higher infiltration of CD163? regenerative M2 macrophages over CD86? M1 macrophages in synovial and chondral tissue, with a concomitant reduction in pro-inflammatory cytokines (TNF-a, IL-1b, and IL-6) and increase in anti-inflammatory cytokine (IL-10) in synovial fluid. CONCLUSION: Our results demonstrated that local sustained-release primary chondrocyte-derived exosomes may relieve OA by promoting the phenotypic transformation of macrophages from M1 to M2, which suggesting a great potential for the application in OA.
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Study on slope stability of waste dump with a weak layer using finite element limit analysis method
Chong Chen,Huayong Lv,Jianjian Zhao,Zhanbo Cheng,Huaiyuan Wang,Gao Xu 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.3
Slope stability is generally paid more attention to in slope protection works, especially for slope containing weak layers. Two indexes of safety factor and failure model are selected to perform slope stability. Moreover, the finite element limit analysis method comprehensively combines the advantage of the limit analysis method and the finite element method obtaining the upper and lower bounds of the safety factor and the failure mode under the slope stability limit state. In this study, taking a waste dump containing a weak layer as an engineering background, the finite element limit analysis method is adopted to explore the potential failure mode. Meanwhile, the sensitivity analysis of slope stability is performed on geometrical and geotechnical parameters of the waste dump. The results show that the failure mode of the waste dump slope is two wedges if the weak layer is located on the ground surface (Model A), while the slope can be observed as three wedges failure if the weak layer is below the ground surface (Model B). In addition, both failure modes are highly sensitive to the friction angle of the weak layer and the shear strength of waste disposal, and moderately sensitive to the heap height, the dip angle and cohesion of the weak layer, while the toe cutting has limited effect on the slope stability. Moreover, the sensitivity to the excavation of the ground depends on the location of the weak layer and failure mode.
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