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- 저자 : Jianhong Huang (검색결과 4 건)
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Tang, Jianhong,Zhang, Zhiyan,Yang, Bin,Guo, Yuanmei,Ai, Huashui,Long, Yi,Su, Ying,Cui, Leilei,Zhou, Liyu,Wang, Xiaopeng,Zhang, Hui,Wang, Chengbin,Ren, Jun,Huang, Lusheng,Ding, Nengshui Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.1
Objective: Three genome-wide association studies (GWAS) and a meta-analysis of GWAS were conducted to explore the genetic mechanisms underlying variation in pig teat number. Methods: We performed three GWAS and a meta-analysis for teat number on three pig populations, including a White Duroc${\times}$Erhualian $F_2$ resource population (n = 1,743), a Chinese Erhualian pig population (n = 320) and a Chinese Sutai pig population (n = 383). Results: We detected 24 single nucleotide polymorphisms (SNPs) that surpassed the genome-wide significant level on Sus Scrofa chromosomes (SSC) 1, 7, and 12 in the $F_2$ resource population, corresponding to four loci for pig teat number. We highlighted vertnin (VRTN) and lysine demethylase 6B (KDM6B) as two interesting candidate genes at the loci on SSC7 and SSC12. No significant associated SNPs were identified in the meta-analysis of GWAS. Conclusion: The results verified the complex genetic architecture of pig teat number. The causative variants for teat number may be different in the three populations
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Wu Dongzhe,Shen Yulin,Qu Chaoyi,Huang Peng,Geng Xue,Zhang Jianhong,Rao Zhijian,Wei Qiangman,Liu Shijie,Zhao Jiexiu 한국역학회 2024 Epidemiology and Health Vol.46 No.-
OBJECTIVES In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging. METHODS Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.2% male) aged 20 and above, OBS and PhenoAgeAccel were calculated. Weighted generalized linear regression models were employed to explore the associations between OBS and PhenoAgeAccel, including a sex-specific analysis. RESULTS The OBS demonstrated significant variability across various demographic and health-related factors. There was a clear negative correlation observed between the higher OBS quartiles and PhenoAgeAccel, which presented sex-specific results: the negative association between OBS and PhenoAgeAccel was more pronounced in male than in female. An analysis using restricted cubic splines revealed no significant non-linear relationships. Interaction effects were noted solely in the context of sex and hyperlipidemia. CONCLUSIONS A higher OBS was significantly associated with a slower aging process, as measured by lower PhenoAgeAccel. These findings underscore the importance of OBS as a biomarker in the study of aging and point to sex and hyperlipidemia as variables that may affect this association. Additional research is required to confirm these results and to investigate the biological underpinnings of this relationship.
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Hengchao Ruan,Suhan Chen,Jingyi Li,Linjuan Ma,Jie Luo,Yizhou Huang,Qian Ying,Jianhong Zhou 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.3
Purpose: This study aimed to identify the risk factors and sonographic variables that could be integrated into a predictive model for endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) in women with abnormal uterine bleeding (AUB). Materials and Methods: This retrospective study included 1837 patients who presented with AUB and underwent endometrial sampling. Multivariable logistic regression was developed based on clinical and sonographic covariates [endometrial thickness (ET), resistance index (RI) of the endometrial vasculature] assessed for their association with EC/AEH in the development group (n=1369), and a predictive nomogram was proposed. The model was validated in 468 patients. Results: Histological examination revealed 167 patients (12.2%) with EC or AEH in the development group. Using multivariable logistic regression, the following variables were incorporated in the prediction of endometrial malignancy: metabolic diseases [odds ratio (OR)=7.764, 95% confidence intervals (CI) 5.042–11.955], family history (OR=3.555, 95% CI 1.055–11.971), age ≥40 years (OR=3.195, 95% CI 1.878–5.435), RI ≤0.5 (OR=8.733, 95% CI 4.311–17.692), and ET ≥10 mm (OR=8.479, 95% CI 5.440–13.216). A nomogram was created using these five variables with an area under the curve of 0.837 (95% CI 0.800–0.874). The calibration curve showed good agreement between the observed and predicted occurrences. For the validation group, the model provided acceptable discrimination and calibration. Conclusion: The proposed nomogram model showed moderate prediction accuracy in the differentiation between benign and malignant endometrial lesions among women with AUB.
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Dry reforming of methane over Ni/SBA-15 catalysts prepared by homogeneous precipitation method
Qiulin Zhang,Jing Wang,Ping Ning,Tengfei Zhang,Mingzhi Wang,Kaixian Long,Jianhong Huang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.11
Ni/SBA-15 catalyst was prepared by homogeneous precipitation method (Ni-HP) and used for dry reforming of methane (DRM). The related characterization results indicated that the Ni particles were highly dispersed with a size range of 2-5 nm. Compared with Ni/SBA-15 catalyst prepared by impregnation (Ni-IM), the reduction temperature of Ni-HP obtained from H2-TPR was greatly improved, suggesting the stronger metal-support interaction. After reacting at 700 oC for 100 h, the CH4 conversion of DRM over Ni-HP catalyst slightly decreased from 74.5% to 73.8%. While, for the Ni-IM catalyst, the CH4 conversion dropped from 61.7% to 37.3%. Furthermore, the average particle size of Ni-HP was 3.7 nm and 4.7 nm before and after the long-time stability test, respectively, ascribed to the good antisintering property. Although a certain amount of coke was produced, mainly with disorder filamentous carbon of basegrowth, the Ni/SBA-15 prepared by homogeneous precipitation exhibited excellent catalytic activity and stability.
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