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- 저자 : Jianbing Qi (검색결과 2 건)
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Pei Xu,Haibo Xiao,Qi Yang,Rui Hu,Lianyong Jiang,Rui Bi,Xueyan Jiang,Lei Wang,Ju Mei,Fangbao Ding,Jianbing Huang 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a potential contributor to oncogenesis in nonsmall-cell lung cancer (NSCLC). We further demonstrated that USP21 was highly expressed in NSCLCs. We then conducted a series of in vitro and in vivo assays to explore the effect of USP21 on NSCLC progression and the underlying mechanism involved. USP21 promoted NSCLC cell proliferation, migration, and invasion and in vivo tumor growth by stabilizing a well-known oncogene, Yin Yang-1 (YY1), via mediating its deubiquitination. Furthermore, YY1 transcriptionally regulates the expression of SNHG16. Moreover, StarBase bioinformatics analyses predicted that miR4500 targets SNHG16 and USP21. A series of in vitro experiments indicated that SNHG16 increased the expression of USP21 through miR-4500. In summary, the USP21/YY1/SNHG16 axis plays a role in promoting the progression of NSCLC. Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment.
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Gaole Zhang,Wenjun Zhang,Jiahao Li,Xinnan Zhou,Wang Liu,Jianbing Qi 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5
Anchor joint is conducive to improving the automation level of the shield tunneling method, whose mechanical behavior is still not fully clear due to the complicated interaction among various structural components. In this paper, a refined FEM model is established and adopted to investigate the anchor joints' assembly and tensile performance. The operation principles of the anchor joint are first introduced for better understanding. Then, a detailed description is presented for the developed refined FEM, including the material properties, structural features, and verification. After that, 76 working conditions in total are set, and an in-depth study is conducted to examine the influence of surface roughness, gap sizes, and strength grades on the assembly and tensile behavior of anchor joints both quantitatively and qualitatively. The results show that the surface roughness mainly influences the maximum assembly load and tensile capacity of anchor joints. The gap size obviously impacts both quantitative and qualitative assembly characteristics and tensile behavior for anchor joints, whose effect is more significant than the surface roughness. The strength grade has a different influence on the distinct mechanical behavior of anchor joints. There is a positive correlation between anchor joints' assembly and tensile behavior. To satisfy the requirement of enough tensile capacity and reasonable assembly difficulty, a good solution should be to reach an appropriate balance between the assembly and tensile behavior of anchor joints.
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