Postoperative radiation therapy following keloidectomy

( Jeongsoo Kim ),( Shinyoung Song ),( Seha Park ),( Seulki Lee ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Keloid is a problem that dermatologists encounter. Patients typically present with cosmetic concerns, although keloids can cause pruritus, pain. Keloids have been treated with multimodal therapy. Radiotherapy treatment after keloidectomy is known to be an effective method for reducing the rate of recurrence. A 40-year-old male presented with erythematous hard plaques on chin, shoulder, right foot. He was treated with steroid intradermal injection for several years but there was no improvement. A 26-year-old female presented an erythematous hard plaque on Lt. upper arm appeared 20 years earlier because of vaccination. She was performed surgical excision but keloid recurred. They had thought in common about new treatment. They were treated with steroid intralesional injection three times before surgery. Keloids were treated with surgical excision, followed by a total radiation dose of 1,800 cGy in three fractions over three days. We will observe their lesion whether keloids recur for 18 months. Postoperative electron-beam irradiation may control collagen synthesis by inhibiting the promotion of abnormal activated and normal fibroblasts. Furthermore, many researchers are trying to set the proper protocols of radiation, keloids should be treated with dose protocols customized by site. Postoperative electron-beam irradiation expects effectively to prevent recurrence of keloid and a safe treatment modality due to absence of complications.

A case of drug-induced hemolytic anemia associated with antibiotic prophylaxis

( Jeongsoo Kim ),( Shinyoung Song ),( Seha Park ),( Seulki Lee ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

A 68-year-old male patient presented with a dark brownish nodule on nose. In a local clinic, he underwent skin biopsy and was diagnosed as basal cell carcinoma. We performed wide excision to remove remaining lesion and clear margin obtained. Immediately before and after the operation he received intravenous cefotetan for antibiotic prophylaxis. On post-operate day 8, he felt dizziness and fell down. Hemoglobin was 3.5g/dL and hematocrit was 12.8%, whereas the initial CBC was normal. There was no evidence of bleeding on physical exam. Total bilirubin (6.86mg/dL), reticulocyte (6.2%) were elevated and direct antiglobulin test was positive. He was diagnosed as drug-induced immune hemolytic anemia (DIIHA) due to cefotetan. After systemic steroid treatment and transfusion a CBC revealed a hemoglobin of 9.4g/dL and hematocrit of 29.3%. He had complete resolution of symptoms and was discharged 5 days later. DIIHA is a rare acquired form of hemolytic anemia caused by interaction of drug with the immune system. Drug adsorption, drug-dependent antibody, and autoimmune induction are the three mechanism of hemolysis. Cefotetan-induced hemolytic anemia (CIHA) has been described to occur through all three mechanisms. Prompt diagnosis and massive systemic steroid administration are essential in minimizing mortality from hemolysis. Herein, we report a rare case of CIHA and hope to be aware of occurrence of CIHA associated with antibiotic prophylaxis.

[P300] Two cases of primary cutaneous nocardiosis caused by intralesional injection

( Jeongsoo Kim ),( Seha Park ),( Seul Ki Lee ),( Ha Ryeong Ryu ),( Heejoo Kim ),( Joo Young Roh ),( Hyang Joon Park ),( Jinok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Nocardiosis is a rare localized or systemic suppurative disease caused by several species of bacteria of the genus Nocardia. Nocardia is an aerobic, filamentous gram-positive, partially acid-fast bacteria belonging to the Actinomycetales order and found in soil, decayed organic matter, water, and air worldwide. Cutaneous nocardiosis is an uncommon infectious disease that presents a primary cutaneous infection or as a part of disseminated pulmonary nocardiosis. First case is a 50-year-old woman who had erythematous patches with swelling on her right arm, who had been treated with triamcinolone intralesional injection at the private clinic. Histopathology of the skin showed diffuse lymphohistiocytic infiltration in the dermis and subcutaneous layer. On Gram staining, gram-positive bacilli were seen, and on modified AFB staining, the branching hyphae stained red purple. White colonies were formed on blood agar medium in pus culture. By bacterial culture and rDNA gene sequencing, the causative organism was identified as N. farcinica. Second case is a 34-year-old woman who presented with erythematous patches and tenderness on Lt.arm. She had been also treated with triamcinolone intralesional injection for keloid at the same clinic as the first patient. She was diagnosed with primary cutaneous nocardiosis by pus culture. Herein, we report rare two cases of primary cutaneous norcardiosis after intralesional injection.

[P231] Hair collar sign in an infant with aplasia cutis congenita associated with nevus flammeus

( Jeongsoo Kim ),( Seha Park ),( Seul Ki Lee ),( Ha Ryeong Ryu ),( Heejoo Kim ),( Jinok Baek ),( Hyang Joon Park ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Aplasia cutis congenita (ACC) is a heterogeneous group of disorders in which localized or widespread areas of skin are absent at birth. ACC manifests as a solitary defect on the scalp in 70% of cases. Although most commonly seenon the scalp, ACC can affect any part of the body. Although pathogenesis of ACC is still unclear, proposed hypotheses are divided into two categories : endogenous causes (developmental failure, congenital syndromes) and exogenous ones (intrauterine trauma, infarction, skin fissure caused by rapid growth). Hair collar sign is a ring of darker and coarser terminal hairs on the scalp, typically surrounding ACC, dermoid cyst, encephalocele, or meningocele. It has been described as a relatively specific marker of neuroectodermal defect. A 5-month-old boy presented with round bald patches with underlying a large reddish patch on posterior occiput. It was surrounded by a rim of terminal hairs. Hair collar sign can be a specific clue for diagnosing ACC. Pregnancy and the delivery had been unremarkable and the baby wasotherwise healthy. Histopathology of the skin showed flattened epidermis, vascular dilatation in the superficial dermis, thickening of vessel walls in the reticular dermis, and absence of adnexal structures. It is assumed that association of ACC with nevus flammeus is that fetal skin development including capillary network formation might have been affected since cranial tube was not closed properly.

Eosinophils play a role in the pathogenesis of psoriasis by stimulating inflammatory cytokine and chemokine production and neutrophil chemotaxis

( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ),( Heejoo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Eosinophilic cytokine profile including IL-23/Th17 axis and their immunomodulatory interaction with other immune cells imply their possible involvement in psoriasis pathogenesis. Objectives: This study was to examine the potential role of eosinophils in imiquimod (IMQ)-induced psoriasiform dermatitis using ΔdblGATA mice, an eosinophil lineage-ablated mouse line. Methods: After topical IMQ application, inflammatory cytokine gene expression and Inflammatory cell populations were analyzed by qRT-PCR and flow cytometry, respectively. Results: Psoriatic features like epidermal thickening, erythema, and scale were less prominent in ΔdblGATA mice after IMQ treatment. Inflammatory cytokines important in psoriasis, like IL-1β, IL-6, IL-22, IL-23, and IL-17, and Th1-/neutrophil-related chemokines CCL2 and CXCL12 were also downregulated, and neutrophils were constantly decreased in the skin, LN, and spleen of ΔdblGATA mice compared to WT mice after IMQ treatment. Although IMQ application increased eosinophils in the skin of WT mice, the absolute cell count was much lower than neutrophils, a major player in psoriasis. Conclusion: The small size of eosinophil population and constant reduction of neutrophil in ΔdblGATA mice than WT mice after IMQ treatment suggest that eosinophils would influence psoriasis indirectly via their inflammatory profile and affecting other mediators in psoriasis, such as neutrophils.

Harmonic-Percussive Sound Separation from Monaural Music Using Generalized Complementary Diffusion

Jeongsoo Park(박정수),Jaeyoung Shin(신재영),Kyogu Lee(이교구) 한국통신학회 2016 한국통신학회 학술대회논문집 Vol.2016 No.6

High fluence 1064-nm Q-Switched Nd:YAG laser : safe and effective treatment of cafe-au-lait macules in Asian patients

( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Heejoo Kim ),( Jooyoung Roh ),( Hyangjoon Park ),( Jinok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Cafe-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. Objectives: To investigate the efficacy and safety of a high fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment of CALMs in Asian patients. Methods: The medical records of thirty-five Korean patients (age range: 1 to 40 years old, mean age : 18.5 years) diagnosed with isolated CALMs were reviewed retrospectively. The patients were treated with a 1064-nm Q-switched Nd:YAG laser. The parameters were a spot size of 7 mm, a fluence of 2.2-2.4 J/cm2 with a slow single sliding-stacking pass, and a pulse rate of 10Hz with a one-week interval for 20-50 sessions. Results: At the week of the final treatment, all treated CALMs showed considerable pigmentation removal without any permanent side effects, such as scaring, mottled hypopigmentation, and post-inflammatory hyperpigmentation (PIH). All treated CALMs showed more than 50% clinical improvement. No recurrence was observed in any of the patients after 12 months of follow up. Conclusion: A high fluence 1064-nm Q-switched Nd:YAG laser treatment of CALMs in Asian patients is a safe and effective method without side effects and recurrence.

제2성전기유대교 제사장직과 민족주의 관념의 세계화

박정수 ( Jeongsoo Park ) 성결대학교 다문화평화연구소 2021 다문화와 평화 Vol.15 No.3

제2성전기유대교 대제사장직의 역사적 변천과정은 유대교의 민족주의 관념이 어떻게 세계화되어 가는지를 보여준다. 제2성전기 유대인들은 민족의 상징인 예루살렘 성전과 성전체제의 정점에 있는 대제사장직을 통하여 야웨의 통치를 종교적으로 구현하고자 했다. 유대인의 이 종교적 민족의식은 팔레스타인에 일어난 헬레니즘 세계화의 격랑 속에서 토라에 헌신된 자들과 마카비 혁명의 저항 민족주의와 깊이 결합되었다. 사독계 대제사장이 하스몬왕조에 의해 대체되면서, 유대인들의 민족주의는 이방인 지배의 현실과 유대교 신정통치의 이상 사이에서 더 관념화되어갔다. 이어진 로마의 지배력은 유대교의 대제사장직의 근간을 흔들어 놓았고, 마침내 유대교의 상징인 성전을 파괴함으로써 유대교 민족주의는 “영성화”되기 시작했다. 이것은 제2성전기를 관통하는 유대교의 핵심적 문제로서, 제사장적 신정통치의 이상과 현실의 긴장 속에서 걸어온 세계화의 길이었다. 예수와 바울의 ‘영적 성전’의 개념과 초기기독교에서 예수의 십자가 죽음에 깊이 각인된 히브리서의 제사장 기독론은 유대교 민족주의의 상징체계인 대제사장직에 관한 관념으로부터 독립된 보편적 종교체계를 표현하고 있는데, 유대인의 종교적 민족주의 관념이 보편화되어 세계화된 결과라고 할 수 있겠다. The process of the historical transformation which the high priesthood experienced in the Second Temple Judaism shows how the concept of Jewish nationalism is globalized. The Jews of the Second Temple Judaism tried to embody religiously Jahwe’s theonomy through Jerusalem temple and the high priesthood at the peak of the temple system, which are symbols of the nation. This religious national consciousness of Jews was deeply combined with the resistance nationalism of the Macabean Revolution and the people devoted to Torah amid the upheaval of Hellenistic globalization in Palestine. With the replacement of the Sadokian high priesthood by the Hasmonean Dynasty, the nationalism of Jews became more ideological between the reality of the Gentiles’ reign and the ideal of Jewish theonomy. Jewish nationalism begins to be “spiritualization” with the continuation of the domination of Rome shaked a Jewish foundaion of high pristhood and finally destroyed temple, a symbol of Judaism. As a result, the replacement of the priesthood by ‘the wise’ in Judaism and ideas of the independent (high)priesthood of early Christianity were the fruits produced in the globalization of Jewish nationalism.

세례 요한의 세례와 마태복음의 죄사함

박정수(Park, Jeongsoo) 한국신약학회 2016 신약논단 Vol.23 No.4

이 글은 초기 기독교가 세례 요한의 세례를 통하여 제의적인 측면에서 유대교로부터 독립할 수 있었던 신학적 근거를 서술함을 목적으로 한다. 세례 요한의 세례는 외적으로 볼 때, 반복할 수 없고 단 한번만 시행되는 점에서 유대교의 정결의식과는 다른 특성을 갖는다. 또 내적인 상징으로는 죄사함과 회개를 이원화시키는 유대교의 제의적 체제와는 달리 “죄사함을 위한 회개의 세례”(막 1:4)라는 일원적인 체제를 가지고 있다. 이런 점에서 요한은 유대교의 성전체제와는 독립적으로 죄사함을 실행하였다는 사실을 주장할 수 있다. 그런데 마태복음에서는 요한의 세례에서 “죄사함을 위한 세례”가 생략된 채 “죄를 고백하는” 세례로 한정하는데(마 3:6), 이는 초기 기독교의 예수 경배와 연관되어 있다. 마가는 성전체제에서 실행되던 죄사함의 권세를 인자 예수에게 부여함으로써 예수의 지상사역과 죄사함을 결부시켰다. 의로운 선지자로서 요한과 예수가 함께 걸어갔던 성전제의 비판과 죽음의 길은 성전의 죄사함의 권세를 대신할 수 있었던 유산이 되었을 것이다. 마태는 이 마가의 전승을 예수의 죽음과 결부시킴으로써 신학적으로 죄사함은 유대교 성전의 정결의식도 요한의 세례도 아닌, 메시아 예수의 성만찬을 통해서 실행되었음을 보여준다. 성례전은 종말론적 일상을 살아가는 공동체에서 성전의 반복적이고 일상적인 죄사함을 대치할 수 있게 한다. 유대 전쟁으로 인한 성전파괴와 유대교의 제의 체계 위기는 마태가 신학화한 세례와 성만찬의 제의적 상징은 기독공동체가 유대교로부터 제의적으로 독립할 수 있는 계기가 되었을 것이다. This paper explores how the early Christianity exemplified in the Gospel of Matthew developed a unique identity vis-à-vis Judaism through its understanding of baptism and the Lord’s supper. The synoptic account of baptism offers a point of entrance into this issue. One of the unique features of John’s baptism is the unitary continuum of repentance and atonement, as articulated in a Markan phrase, “a baptism of repentance for the forgiveness of sins” (Mark 1:4). Matthew reflects a level of further development when he combines the act of being baptized with confession of sins (Matt 3:6), removing “ει´ς ά´φεσιν α`μαρτιών” of the Markan tradition. For Matthew, the remission of sins is reserved for the Messiah who would achieve it through his sacrificial death on the cross. That is why Matthew adds the phrase “ει´ς ά´φεσιν α`μαρτιών” to the scene of the Lord’s Supper in Mark. Jesus died not only “for many,” but “for the remission of sins” according to the Matthean version of the Word of Institution (Matt 26:28). The forgiveness of sins is connected not so much with the unique action of baptism as with the repetitive sacramental rite of Lord’s Supper. The Jewish war which resulted in the destruction of the Temple and its cults might motivate the Matthean community to initiate her own cultic system, by which Christianity parted its ways farther with Judaism.

헬레니즘 시대 유대교와 기독교의 가족 에토스

박정수 ( Jeongsoo Park ) 성결대학교 다문화평화연구소 2020 다문화와 평화 Vol.14 No.2

기원후 70년 예루살렘과 제2성전의 파괴로 유대인들은 민족과 신앙의 상징적 공간을 상실하고 이국땅에서 디아스포라 공동체를 이루고 살아가야 했다. 이 시기를 포함해서 제2성전 시기 특히 헬레니즘 시대 유대인 공동체의 실제적인 존속형태는 가족이었다. 유대인의 역사는 출산에 의해 존속되고 교육으로 건설된다. 혈연과 유대교 전통의 계승이 역사의 씨줄과 날줄이었다면 토라는 역사라는 시공간의 철학적 토대였다. 가족 에토스는 그런 역사 철학과 토라의 종교인 유대교에 터한 유대인의 민족적 에토스를 건설하는 근간이었다. 헬레니즘 시대 유대교에서 출생한 예수 운동은 ‘하나님의 가족’이라는 공동체적 정체성을 가지고 출발했다. 이는 “하나님의 뜻을 행하는 자는 누구나”가 들어올 수 있는 개방성을 가지고 있으며, 혈연 혹은 사회적 계층이나 민족적 범주를 넘어서는 보편성을 가지고 있었다. 예수의 식탁공동체 형성은 이웃사랑의 에토스를 통해서 ‘하나님의 가족’의 보편성을 구체화하는 예수의 상징행위였다. 또한 헬레니즘 시대 유대교의 가족의 근간은 형제자매의 관계였다. 이러한 토대에서 초기 기독교 공동체는 가족에 관한 언어로 자신들의 신앙을 표현하며 예수를 주인으로, 공동체 구성원을 형제자매로 표현할 수 있었다. 그들은 이 언어적 상징의 중심에서 예수의 이웃사랑을 새로운 삶의 중심 가치인 형제사랑의 에토스로 구현했다. 바로 이것이 기독교의 신앙언어가 가족의 용어로 표현된 ‘삶의 자리’이다. The destruction of Jerusalem and the Second Temple in 70 A.D. caused Jews to lose symbolic space of ethnicity as well as faith and to live in a diaspora community on foreign lands. Including this period, the actual form of existence of the Jewish community in the Second Temple, was Family especially in the whole Hellenistic period. The Jewish history is preserved by birth and built with education. The succession of blood ties and Jewish traditions were the lines of history, Tora was the philosophical foundation of history as time and space. The family ethos was the basis for building such historical philosophy and the ethnic ethos of Jews in the Jewish religion of Torah. Born in Hellenistic Judaism, the ‘Jesus movement’ started with the community identity of ‘Family of God’. This had the openness in terms of that “anyone who practices God’s will” could be accepted, and universality beyond blood ties or social classes or ethnic categories. The formation of a table community of Jesus was his symbolic action which realizes the universality of the table community concretely through the ethos of neighborly love. Also, the basis of the Jewish family in Hellenistic period was the relationship between siblings. On this basis, early Christian communities were able to express their faith in the language of their families, expressing Jesus as their ‘Lord’ and their community members as ‘Sister and brother.’ In the center of this linguistic symbol, they embodied Jesus’ love for his neighbor as the ethos of brotherly love, the central value of his new life. This is the “Sitz im Leben” in which Christian religious language is expressed in family terms.