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Prognostic impact of inferior mesenteric artery lymph node metastasis in colorectal cancer.
Kang, Jeonghyun,Hur, Hyuk,Min, Byung Soh,Kim, Nam Kyu,Lee, Kang Young Raven Press 2011 Annals of Surgical Oncology Vol.18 No.3
<P>The aims of this study are to identify the natural course of inferior mesenteric artery (IMA) lymph node metastasis, and to evaluate the prognostic impact of IMA lymph node metastasis in the sigmoid colon and rectal cancer.</P>
Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer
Kang, Jeonghyun,Park, Joon Seong,Ahn, Sung Gwe,Lim, Jin Hong,Baik, Seung Hyuk,Yoon, Dong Sup,Lee, Kang Young,Jeong, Joon The Korean Surgical Society 2018 Annals of Surgical Treatment and Research(ASRT) Vol.95 No.3
<P><B>Purpose</B></P><P>This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer.</P><P><B>Methods</B></P><P>This retrospective study analyzed 42 patients who were randomly assigned to receive a FOLFOX regimen with or without KRG. Spleen volume change was assessed by computed tomography scans measured before surgery (presurgery volume) and 3 weeks after cessation of the 12th cycle of FOLFOX (postchemotherapy volume).</P><P><B>Results</B></P><P>All patients showed increased spleen volume. No difference was observed in median presurgery and postchemotherapy volume between the KRG and control groups. However, a ratio defined as postchemotherapy volume divided by presurgery volume was significantly lower in the KRG group than the control group (median, 1.38 [range, 1.0–2.8] in KRG group vs. median, 1.89 [range, 1.1–3.0] in control group, P = 0.028). When splenomegaly was defined as a >61% increase in spleen volume, the rate of splenomegaly was significantly lower in the KRG group than the control group (28.6% <I>vs</I>. 61.9%, P = 0.03). KRG consumption was inversely associated with developing splenomegaly in multivariate analysis.</P><P><B>Conclusion</B></P><P>Adding KRG during FOLFOX chemotherapy for colon cancer might protect against oxaliplatin-induced splenomegaly. The protective effect of Korean red ginseng should be investigated with further research.</P>
Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer
Jeonghyun Kang,Joon Seong Park,Sung Gwe Ahn,Jin Hong Lim,Seung Hyuk Baik,Dong Sup Yoon,Kang Young Lee,Joon Jeong 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.95 No.3
Purpose: This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer. Methods: This retrospective study analyzed 42 patients who were randomly assigned to receive a FOLFOX regimen with or without KRG. Spleen volume change was assessed by computed tomography scans measured before surgery (presurgery volume) and 3 weeks after cessation of the 12th cycle of FOLFOX (postchemotherapy volume). Results: All patients showed increased spleen volume. No difference was observed in median presurgery and postchemotherapy volume between the KRG and control groups. However, a ratio defined as postchemotherapy volume divided by presurgery volume was significantly lower in the KRG group than the control group (median, 1.38 [range, 1.0–2.8] in KRG group vs. median, 1.89 [range, 1.1–3.0] in control group, P = 0.028). When splenomegaly was defined as a >61% increase in spleen volume, the rate of splenomegaly was significantly lower in the KRG group than the control group (28.6% vs. 61.9%, P = 0.03). KRG consumption was inversely associated with developing splenomegaly in multivariate analysis. Conclusion: Adding KRG during FOLFOX chemotherapy for colon cancer might protect against oxaliplatin-induced splenomegaly. The protective effect of Korean red ginseng should be investigated with further research.