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( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Caffeine intake and consumption of coffee were estimated from food frequency questionnaires results these are increasing. Caffeine may repair skin damage induced by excessive exposure to ultraviolet light. In previous report of the associations between coffee consumption and incidence of these skin cancers, the result that the consumption of neither caffeinated nor decaffeinated coffee was associated with basal cell carcinoma and squamous cell carcinoma (SCC). Objectives: In this study, our aim is to describe the mechanisms of the anti-angiogenic effect of caffeine in human umbilical vein endothelial cells (HUVECs) and head and neck squamous cell carcinoma (HNSCC). Methods: Matrigel assays were used to investigate the effect of caffeine on angiogenesis at cell migration and wound healing and proliferation assays using HUVECs and HNSCC. Results: Caffeine was found to inhibit blood vessel formation dose-dependently and to inhibit the proliferation of HUVECs time- and dose-dependently. The apoptosis examination was used by western blotting and immunofluorescence staining. Conclusion: Caffeine was found to inhibit blood vessel formation dose-dependently and to inhibit the proliferation of HUVECs on the same manners. There is no satisfactory enhancement and/or inhibition on proliferation of HNSCC.
P191 The clinicopathologic study of multiple dermatofibroma
( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Dermatofibromas are common, benign, painless dermal nodules. Although cases of solitary dermatofibromas are common, multiple dermatofibromas are rare and there is no explainable theory in healthy people. Objectives: This study was conducted to obtain better understanding of the clinicopathologic features of multiple dermatofibroma. Methods: This is a retrospective study of multiple dermatofibroma pathologically diagnosed at our hospital over a 12-year period (2004~2015). Clinicopathologic features of 22 patients, 108 lesions were evaluated. The sex, age, number of lesions, site, symptoms and histopathological finding are included. Results: Of the 22 patients, sixteen (72.7%) were female and six (27.3%) were male. mean age was 39.1(±11.5) years old. The number of lesions ranged 2 to 20 and the mean was 4.9. The most common predilection sites were lower extremities (42.6%). All cases treated by excisional biopsy. According to the histopathological finding, the most common histological subtype was fibrocollagenous (66.7%). Most of the cases were extended dermis (62.5%) layer. Mitotic activity was not definite in majority of cases. The major infiltrated inflammatory cells were lymphocyte (75.2%). Conclusion: Multiple and solitary dermatofibroma have clinical and pathological consistency except for numbers of lesions.
A survey of knowledge and behavior regarding self examination of skin cancer
( Jeong Won Jo ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: The recognition of self examination of cancer has increased more than before. Although skin cancers are almost always curable when found and removed early, most patients are little known about general awareness of skin cancer. Objectives: In this study, we survey on satisfaction of clinic education to the 40 patients treated with skin cancer and affection to behavioral change. Methods: We reviewed a written questionnaire and patients’ self-examination records including patients’ age, method of self-examination, and skin check point. Results: The most patients replay (90%, 36/40) and want to know the warning signs of skin cancer and what to look for during the self-examination (88%, 32/36). The results show the most of patients want to help you make the next your dermatologist’s appointment (81%, 29/36). At time of check self-examination, the patients use the record paper prepared from our clinic (69.4%, 25/36). Conclusion: Although the patients treated with precancer and cancer area aware that the risk of skin cancer and they want to know about self-examination of skin cancer. Therefore, most popular skin cancer education and prevention program include self-skin examination is more required and dermatologist should play a major role in this action.
A caes of eruptive lichen planus
( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Eruptive lichen planus is a rare variant of lichen planus and variety of rapidly spreading and extensive form of lichen planus. Lichen planus is a common and chronic inflammatory disease of the skin and mucous membranes. It typically manifests as pruritic, faintly erythematous to violaceous, flat-topped, polygonal papules distributed mainly over the flexural areas of wrists, arms, and legs. It usually resolves after a variable period of time, ranging from a few months to years, leaving behind pigmentation and/or scarring. The exact pathogenesis of lichen planus is not clear. Association of a chronic active hepatitis C virus infection with lichen planus and triggering of lichen planus following a hepatitis B virus vaccination has been previously described. So we report the eruptive lichen planus in patients who have received treatment with hepatitis B infection.
[P044] A case of pretibial thyroid dermopathy
( Jeong Won Jo ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Pretibial myxedema(PM) is a dermatological manifestation of Graves` disease, which commonly presents as diffuse, non-pitting edema of shins and less often as plaques, nodules, or elephantiasis lesions mimicking lymphedema. Most common site is pretibial area and localized thickening of the pretibial skin causes deposition of acid mucopolysaccharides. There are 7 cases of pretibial myxedema reported in domestic dermatology literature. The only four of cases occurred after treatment of hyperthyroidism like that our case. Herein, we report a case of pretibial myxedema with Grave`s disease and Grave`s ophthalmopathy. A 51-year-old male visited our department with multiple erythematous patches and nodules on Lt. pretibial area. He had been diagnosed with Grave`s disease 6 months ago and Grave`s ophthalmopathy 3 months ago. The incisional biopsy on Lt. pretibial area showed mucinosis in dermis with perivascular lymphocytic infiltration. The lesions improved after steroid intralesional injection. For persisted local lesions despite improvement of systemic symptoms, we propose that the steroid intralesional injection may be an alternative to treatment.
Jeong, Yeon Ik,Park, Chi Hun,Kim, Huen Suk,Jeong, Yeon Woo,Lee, Jong Yun,Park, Sun Woo,Lee, Se Yeong,Hyun, Sang Hwan,Kim, Yeun Wook,Shin, Taeyoung,Hwang, Woo Suk Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.12
Many different approaches have been developed to improve the efficiency of animal cloning by somatic cell nuclear transfer (SCNT), one of which is to modify histone acetylation levels using histone deacetylase inhibitors (HDACi) such as trichostatin A (TSA). In the present study, we examined the effect of TSA on in vitro development of porcine embryos derived from SCNT. We found that TSA treatment (50 nM) for 24 h following oocyte activation improved blastocyst formation rates (to 22.0%) compared with 8.9% in the non-treatment group and total cell number of the blastocysts for determining embryo quality also increased significantly ($88.9{\rightarrow}114.4$). Changes in histone acetylation levels as a result of TSA treatment were examined using indirect immunofluorescence and confocal microscopy scanning. Results showed that the histone acetylation level in TSA-treated embryos was higher than that in controls at both acetylated histone H3 lysine 9 (AcH3K9) and acetylated histone H4 lysine 12 (AcH4K12). Next, we compared the expression patterns of seven genes (OCT4, ID1; the pluripotent genes, H19, NNAT, PEG1; the imprinting genes, cytokeratin 8 and 18; the trophoblast marker genes). The SCNT blastocysts both with and without TSA treatment showed lower levels of OCT4, ID1, cytokeratin 8 and 18 than those of the in vivo blastocysts. In the case of the imprinting genes H19 and NNAT, except PEG1, the SCNT blastocysts both with and without TSA treatment showed higher levels than those of the in vivo blastocysts. Although the gene expression patterns between cloned blastocysts and their in vivo counterparts were different regardless of TSA treatment, it appears that several genes in NT blastocysts after TSA treatment showed a slight tendency toward expression patterns of in vivo blastocysts. Our results suggest that TSA treatment may improve preimplantation porcine embryo development following SCNT.
[P046] Erythema multiforme with atypical clinical features
( Jeong Won Jo ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Erythema multiforme (EM) is a hypersensitivity reaction characterized by targetoid skin lesions with or without erosions of mucosal surfaces. An acute, self-limiting or episodic course and the presence of targetoid lesions, raised atypical papules or mucosal involvement, are the important clues to diagnose with EM. Laboratory studies and skin biopsies are not required in all cases of EM. EM has been classified into a number of variants, mainly minor and major forms. In the case of general EM major, the mucosal lesions as well as the cutaneous lesions are also more severe and cover a wide range of skin surface. However, we examined a case of EM with atypical clinical features. Unlike general EM major, the cutaneous lesions of our patient were mild and limited to hands and feet that uncommonly involved, although the erosive lesions of oral and genital mucosa were severe. This atypical feature caused misdiagnosis to hand, foot and mouth disease and led to delay proper treatment. In conclusion, we should be recognized that there is a case of EM with atypical clinical features and refer to it when diagnosing.
P098 A clinical study on herpes zoster during the last 5-year-period (2011-2015)
( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Herpes zoster is a common dermatologic disease. But there has not been any report on the clinical characteristics of herpes zoster in the Province of Gyeongsangnam-do. Objectives: The purpose of this study was the elucidation of the clinical characteristics of herpes zoster in the Province of Gyeongsangnam-do. Methods: The study was conducted between 2011 and 2015 at our hospital outpatients. 901 patients with herpes zoster were evaluated in regard to age, sex, dermatomic distributions, associated diseases and complications. Results: Out of 901 cases, 396 were males and 505 were females. The maximum incidence was in the over 70 year-old group (26.4%). The most frequent involved dermatome was the trigeminal dermatome (28.7%). Associated diseases were observed in 679 patients (75.3%), which included hypertension (21.2%), malignancy (11.4%) and so on. Out of 901 patients, 443 (49.2%) developed complications. The most common complication was postherpetic neuralgia (27.1%). It is noteworthy that skin edema was accompanied from 43 patients (4.8%). Fourty patients showed edematous change on herpes zoster lesion. But other 3 patients showed facial edema in spite of involving herpes zoster in other area. Conclusion: Most of the results are similar to those previously reported, except for a higher incidence in trigeminal dermatome. The most interesting part of this study is herpes zoster can cause skin edema. We need to take further studies in future by others to explain causes in detail.