Erythema multiforme (EM) is a hypersensitivity reaction characterized by targetoid skin lesions with or without erosions of mucosal surfaces. An acute, self-limiting or episodic course and the presence of targetoid lesions, raised atypical papules or ...
Erythema multiforme (EM) is a hypersensitivity reaction characterized by targetoid skin lesions with or without erosions of mucosal surfaces. An acute, self-limiting or episodic course and the presence of targetoid lesions, raised atypical papules or mucosal involvement, are the important clues to diagnose with EM. Laboratory studies and skin biopsies are not required in all cases of EM. EM has been classified into a number of variants, mainly minor and major forms. In the case of general EM major, the mucosal lesions as well as the cutaneous lesions are also more severe and cover a wide range of skin surface. However, we examined a case of EM with atypical clinical features. Unlike general EM major, the cutaneous lesions of our patient were mild and limited to hands and feet that uncommonly involved, although the erosive lesions of oral and genital mucosa were severe. This atypical feature caused misdiagnosis to hand, foot and mouth disease and led to delay proper treatment. In conclusion, we should be recognized that there is a case of EM with atypical clinical features and refer to it when diagnosing.