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Jafary, Fariba,Salehi, Mansoor,Sedghi, Maryam,Nouri, Nayereh,Jafary, Farzaneh,Sadeghi, Farzaneh,Motamedi, Shima,Talebi, Maede Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were assessed using the polymerase chain reaction and single strand conformational polymorphism. For comparing the genotype frequencies of patients and controls the chi-square test was applied. The obtained result indicated that there was significantly association between G/A genotype of MSH3 codon 222 and G/G genotype of MSH3 codon 1036 with an increased PC risk (P=0.012 and P=0.02 respectively). Our results demonstrated that MSH3 codon 222 and MSH3 codon 1036 polymorphisms may be risk factors for sporadic prostate cancer in the Iranian population.
Abolfazl Jafari Natanzi,Gholamreza Soleimani Jafari,Reza Kolahchi 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.5
In this study, nonlinear vibration and stability of a polymeric pipe reinforced by single-walled carbon naotubes (SWCNTs) conveying fluid-nanoparticles mixture flow is investigated. The Characteristics of the equivalent composite are determined using Mori-Tanaka model considering agglomeration effects. The surrounding elastic medium is simulated by orthotropic visco-Pasternak medium. Employing nonlinear strains-displacements, stress-strain energy method the governing equations were derived using Hamilton's principal. Differential quadrature method (DQM) is used for obtaining the frequency and critical fluid velocity. The influence of volume percent of SWCNTs, agglomeration, geometrical parameters of pipe, viscoelastic foundation and fluid velocity are shown on the frequency and critical fluid velocity of pipe. Results showed the increasing volume percent of SWCNTs leads to higher frequency and critical fluid velocity.
Jafari-Koshki, Tohid,Mansourian, Marjan,Mokarian, Fariborz Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: Breast cancer is a fatal disease and the most frequently diagnosed cancer in women with an increasing pattern worldwide. The burden is mostly attributed to metastatic cancers that occur in one-third of patients and the treatments are palliative. It is of great interest to determine factors affecting time from cancer diagnosis to secondary metastasis. Materials and Methods: Cure rate models assume a Poisson distribution for the number of unobservable metastatic-component cells that are completely deleted from the non-metastasis patient body but some may remain and result in metastasis. Time to metastasis is defined as a function of the number of these cells and the time for each cell to develop a detectable sign of metastasis. Covariates are introduced to the model via the rate of metastatic-component cells. We used non-mixture cure rate models with Weibull and log-logistic distributions in a Bayesian setting to assess the relationship between metastasis free survival and covariates. Results: The median of metastasis free survival was 76.9 months. Various models showed that from covariates in the study, lymph node involvement ratio and being progesterone receptor positive were significant, with an adverse and a beneficial effect on metastasis free survival, respectively. The estimated fraction of patients cured from metastasis was almost 48%. The Weibull model had a slightly better performance than log-logistic. Conclusions: Cure rate models are popular in survival studies and outperform other models under certain conditions. We explored the prognostic factors of metastatic breast cancer from a different viewpoint. In this study, metastasis sites were analyzed all together. Conducting similar studies in a larger sample of cancer patients as well as evaluating the prognostic value of covariates in metastasis to each site separately are recommended.
Jafari-Kashi Abbas,Shabani-Nooshabadi Mehdi,Rafiee-Pour Hossain-Ali 한국탄소학회 2024 Carbon Letters Vol.34 No.3
Bortezomib (BTZ) and dasatinib (DA) are two substantial anti-cancer agents with side effects on the human body. In this research, we fabricated a novel electrochemical sensor modified by CuFe2O4/SmVO4 nanocomposite and 1-ethyl-3-methylimidazolium chloride (1E3MC) as an ionic liquid (IL) (CuFe2O4/SmVO4/IL/CPE) for coinciding investigation of BTZ and DA for the first time. The CuFe2O4/SmVO4 synthesized were determined and certified through field-emission scanning electron microscopy (FE-SEM), energy diffraction X-ray (EDX), and X-ray diffraction (XRD). The capability of the sensor was investigated by different electrochemical techniques such as cyclic voltammetry (CV), chronoamperometry (CHA), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The attained data showed that the oxidation signal of bortezomib and dasatinib promoted as an innovative electrochemical sensor. After optimization of the conditions using this sensor at pH 7.0, the oxidation signal of bortezomib and dasatinib showed to be linear with drug concentrations in the range of 0.09–90 µM and 100–500 µM with a detection limit of 5.4 nM and 7.0 µM, respectively, using differential pulse voltammetry method. The values of D and electro-transfer coefficient (α) achieved 2.5 × 10−5 cm2 s−1 and 0.99, respectively. The proposed electrochemical sensor exhibited acceptable selectivity and sensitivity for simultaneous detection of bortezomib and dasatinib in pharmaceutical and biological samples.
Jafari, Seyed A.,Kosasih, Buyung Techno-Press 2014 Wind and Structures, An International Journal (WAS Vol.19 No.2
Reported experimental and computational fluid dynamic (CFD) studies have demonstrated significant power augmentation of diffuser shrouded horizontal axis micro wind turbine compared to bare turbine. These studies also found the degree of augmentation is strongly dependent on the shape and geometry of the diffuser such as length and expansion angle. However study flow field over the rotor blades in shrouded turbine has not received much attention. In this paper, CFD simulations of an experimental diffuser shrouded micro wind turbine have been carried out with the aim to understand the mechanisms underpinning the power augmentation phenomenon. The simulations provide insight of the flow field over the blades of bare wind turbine and of shrouded one elucidating the augmentation mechanisms. From the analysis, sub-atmospheric back pressure leading to velocity augmentation at the inlet of diffuser and lowering the static pressure on blade suction sides have been identified as th dominant mechanisms driving the power augmentation. And effective augmentation was achieved for ${\lambda}$ above certain value. For the case turbine it is ${\lambda}$ greater than ${\approx}2$.
Jafari, Naser,Zargar, Seyed Jalal,Yassa, Narguess,Delnavazi, Mohammad Reza Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Objective: Dorema glabrum Fisch. & C.A. Mey is a perennial plant that has several curative properties. Anti-proliferative activity of seeds of this plant has been demonstrated in a mouse fibrosarcoma cell line. The aim of the present study was to evaluate cytotoxicity of D. glabrum root extracts in a human gastric adenocarcinoma (AGS) cell line and explore mechanisms of apoptosis induction, cell cycle arrest and altered gene expression in cancer cells. Materials and Methods: The MTT assay was used to evaluate IC50 values, EB/AO staining to analyze the mode of cell death, and flow cytometry to assess the cell cycle. Quantitative real-time polymerase chain reaction (qRT-PCR) amplification was performed with apoptosis and cell cycle-related gene primers, for cyclin D1, c-myc, survivin, VEGF, Bcl-2, Bax, and caspase-3 to determine alteration of gene expression. Results: Our results showed that n-hexane and chloroform extracts had greatest toxic effects on gastric cancer cells with IC50 values of $6.4{\mu}g/ml$ and $4.6{\mu}g/ml$, respectively, after 72 h. Cell cycle analysis revealed that the population of treated cells in the G1 phase was increased in comparison to controls. Cellular morphological changes indicated induction of apoptosis. In addition, mRNA expression levels of Bax and caspase-3 were increased, and of bcl-2 survivin, VEGF, c-myc and cyclin D1 were decreased. Conclusion: Our study results suggest that D. glabrum has cytotoxic effects on AGS cells, characterized by enhanced apoptosis, reduced cell viability and arrest of cell cycling.
REMARKS ON THE INNER POWER OF GRAPHS
JAFARI, S.,ASHRAFI, A.R.,FATH-TABAR, G.H.,TAVAKOLI, Mostafa The Korean Society for Computational and Applied M 2017 Journal of applied mathematics & informatics Vol.35 No.1
Let G be a graph and k is a positive integer. Hammack and Livesay in [The inner power of a graph, Ars Math. Contemp., 3 (2010), no. 2, 193-199] introduced a new graph operation $G^{(k)}$, called the $k^{th}$ inner power of G. In this paper, it is proved that if G is bipartite then $G^{(2)}$ has exactly three components such that one of them is bipartite and two others are isomorphic. As a consequence the edge frustration index of $G^{(2)}$ is computed based on the same values as for the original graph G. We also compute the first and second Zagreb indices and coindices of $G^{(2)}$.
Local buckling of thin and moderately thick variable thickness viscoelastic composite plates
Jafari, Nasrin,Azhari, Mojtaba,Heidarpour, Amin Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.6
This paper addresses the finite strip formulations for the stability analysis of viscoelastic composite plates with variable thickness in the transverse direction, which are subjected to in-plane forces. While the finite strip method is fairly well-known in the buckling analysis, hitherto its direct application to the buckling of viscoelastic composite plates with variable thickness has not been investigated. The equations governing the stiffness and the geometry matrices of the composite plate are solved in the time domain using both the higher-order shear deformation theory and the method of effective moduli. These matrices are then assembled so that the global stiffness and geometry matrices of a moderately thick rectangular plate are formed which lead to an eigenvalue problem that is solved to determine the magnitude of critical buckling load for the viscoelastic plate. The accuracy of the proposed model is verified against the results which have been reported elsewhere whilst a comprehensive parametric study is presented to show the effects of viscoelasticity parameters, boundary conditions as well as combined bending and compression loads on the critical buckling load of thin and moderately thick viscoelastic composite plates.