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Effects of Smoking Cessation on Gene Expression in Human Leukocytes of Chronic Smoker
SooJeong Kim,SuYoung Kim,JaeHwa Kim,DaiJin Kim 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.3
Objective-The risks of cigarette smoking concerning higher systemic disease mortality are lessened by smoking cessation. Methods-Microarray analysis compared the expression profiles of smokers who were successful and not successful at smoking cessation, with the goal of identifying genes that might serve as potential biomarkers or that might be valuable in elucidating distinct biological mechanisms. The mRNAs were isolated and compared from peripheral leukocytes of six smokers who were successful in cessation and six smokers who failed in smoking cessation. Results-Two hundred ninety nine genes displayed significantly different expression; 196 genes were up-regulated and 103 genes were down-regulated in the success group compared to the failure group. Twenty four of these genes were identified with biological processes including immunity, cytoskeleton and cell growth/cycle. Real-time PCR confirmed the differential gene expression. The mRNA levels of HEPACAM family member 2 (HEPACAM2) and tropomodulin 1 (TMOD1) were significantly more expressed in the success group, while the mRNA ubiquitin specific peptides 18 (USP18) were significantly less expressed in the success group compared to the failure group. Conclusion-The results suggest that smoking cessation can modulate cell adhesion and immune response by regulating expression levels of genes, especially HEPACAM2, TMOD1 and USP18, which have an important relationship with smoking cessation.
( Jaehwa Choi ),( Bonil Park ),( Bumjoon Kim ),( Keun Bae Jeong ),( Seok Jeong Lee ),( Sang-ha Kim ),( Won-yeon Lee ),( Suk Joong Yong ),( Myoung Kyu Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Introduction: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are important causes of hospital admission and mortality. We investigated the clinical features of hospitalized patients with severe AECOPD and evaluated prognostic factors associated the readmission or mortality due to re-exacerbation of COPD within 6 months. Methods: The prospective study was enrolled 314 patients who hospitalized with severe AECOPD. And we collected demographic, clinical and laboratory findings at admission. Lung function was evaluated using the COPD assessment test (CAT) questionnaire, the modified Medical Research Council (mMRC) dyspnea scale, and spirometry in the stable state. Results: The mean age was 72.2±9.4 years (76.4% of male), and the rate of readmission within 6 months was 45.2% and mortality rate was 16.6%. When multivariate analysis was performed by using the significant variables, age (p<0.001), CAT score (p<0.001), initial PaO2 (p=0.026), hemoglobin (p=0.009), albumin (p=0.005) and CRP at discharge (p<0.001) were significantly associated with mortality. And also CAT score (p<0.001) and CRP at discharge (p=0.004) were significantly associated with readmission. In receiver operating characteristic curves, CRP at discharge than CAT score showed a good accuracy to predict the mortality. But CAT score showed good accuracy to predict readmission due to severe AECOPD. Conclusions: CRP at discharge as well as CAT score was significantly associated with both mortality and readmission due to AECOPD.
Lim, Jaehwa,Yun, Seong Hwan,Kim, Mi-Ra,Kim, Il American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.10
<P>A new type of polycarbonate (PC) polyol was prepared by copolymerization of carbon dioxide with cyclohexene oxide (CHO) using double-metal cyanide (DMC) catalysts. These heterogeneous DMC catalysts were prepared by reacting ZnCl2 and K3Co(CN)(6) in the presence of various complexing agents (CAs) such as 2-methoxyethyl acetate, 2-ethoxyethyl acetate (EEA), 2-butoxyethyl acetate, diethyl glycol monoethyl ether acetate, ethylene glycol diacetate, and 4-hydroxy-4-methyl-2-pentanone. The catalysts were intensively characterized by infrared and X-ray photoelectron spectroscopy and X-ray powder diffraction. All of the developed catalysts showed high activity and carbonate selectivity, with EEA as the most effective CA. The copolymerization behavior was investigated in detail by varying the amounts of catalyst, CHO, starter and solvent, the carbon dioxide pressure, temperature, and reaction time. The resultant PC polyols had a wide range of molecular weights and narrow polydispersity. Specifically, bifunctional PC polyols were obtained using bifunctional poly(propylene glycol) as a starter.</P>