http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
T.C. Baker,E.C. Smyers,J.M. Urban,Z. Meng,K.J. Pagadala Damadaram,A.J. Myrick,M.F. Cooperband,M.J. Domingue 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.3
During the summer and fall of 2017 in northeastern Pennsylvania we studied the progression of adult behaviors of the spotted lanternfly, Lycorma delicatula (Hemiptera: Fulgoridae) when there was an upsurge in adult flight behavior that was not known to have occurred in 2015 or 2016, the first years following its initial detection in Pennsylvania in late 2014. Sex ratios on A. altissima trunks and branches were routinely ca. 50:50 male:female throughout the 2017 season except in two instances in two of the earliest samplings in which > 60% were males. Within the first week after adult eclosion in 2017, in conjunction with extensive feeding-related behaviors on Ailanthus altissima tree trunks, short flights occurred indiscriminately from the foliage of one tree to another or between bushes, trees and vines. One week later these flights became more prevalent and lengthier. Adults of both sexes launched themselves into the wind from non-host trees or from porches, posts and other human-made structures to engage in level or gradually descending straight-line flight trajectories that allowed them to traverse only usually 10 to 40 m of ground in one episode. After the peak of flight dispersal had occurred, the first mating pairs were observed on September 25. All of the 21 pairs of adults we observed in copula exhibited swollen, yellow abdomens in contrast to the thinner, predominantly black abdomens of the adults we had sampled during the earlier feeding and flight phases. Copulating pairs were observed to remain coupled for 2 to 4 h
e-SELECT Investigators,Urban, P.,Abizaid, A.,Banning, A.,Bartorelli, A.L.,Baux, A.C.,Dzavik, V.,Ellis, S.,Gao, R.,Holmes, D.,Jeong, M.H.,Legrand, V.,Neumann, F.J.,Nyakern, M.,Spaulding, C.,Worthley, S Elsevier Biomedical 2011 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.57 No.13
Objectives: The aim of this study was to ascertain the 1-year incidence of stent thrombosis (ST) and major bleeding (MB) in a large, unselected population treated with sirolimus-eluting stents (SES). Background: Stent thrombosis and MB are major potential complications of drug-eluting stent implantation. Their relative incidence and predisposing factors among large populations treated worldwide are unclear. Methods: The SES were implanted in 15,147 patients who were entered in a multinational registry. We analyzed the incidence of: 1) definite and probable ST as defined by the Academic Research Consortium; and 2) MB, with the STEEPLE (Safety and efficacy of Enoxaparin in PCI) definition, together with their relation to dual antiplatelet therapy (DAPT) and to 1-year clinical outcomes. Results: The mean age of the sample was 62 +/- 11 years, 30.4% were diabetic, 10% had a Charlson comorbidity index ≥3, and 44% presented with acute coronary syndrome or myocardial infarction. At 1 year, the reported compliance with DAPT as recommended by the European Society of Cardiology guidelines was 86.3%. Adverse event rates were: ST 1.0%, MB 1.0%, mortality 1.7%, myocardial infarction 1.9%, and target lesion revascularization 2.3%. Multivariate analysis identified 9 correlates of ST and 4 correlates of MB. Advanced age and a high Charlson index were associated with an increased risk of both ST and MB. After ST, the 7-day and 1-year all-cause mortality was 30% and 35%, respectively, versus 1.5% and 10% after MB. Only 2 of 13,749 patients (0.015%) experienced both MB and ST during the entire 1-year follow-up period. Conclusions: In this worldwide population treated with ≥1 SES, the reported compliance with DAPT was good, and the incidence of ST and MB was low. Stent thrombosis and MB very rarely occurred in the same patient. (The e-SELECT Registry: a Multicenter Post-Market Surveillance; NCT00438919)
Fü,lö,p, Tamá,s,Nemes, Ré,ka,Mé,szá,ros, Tamá,s,Urbanics, Rudolf,Kok, Robbert Jan,Jackman, Joshua A.,Cho, Nam-Joon,Storm, Gert,Szebeni, Já,nos Elsevier 2018 Journal of controlled release Vol.270 No.-
<P><B>Abstract</B></P> <P>The unique magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) have led to their increasing use in drug delivery and imaging applications. Some polymer-coated SPIONs, however, share with many other nanoparticles the potential of causing hypersensitivity reactions (HSRs) known as complement (C) activation-related pseudoallergy (CARPA). In order to explore the roles of iron core composition and particle surface coating in SPION-induced CARPA, we measured C activation by 6 different SPIONs in a human serum that is known to react to nanoparticles (NPs) with strong C activation. Remarkably, only the carboxymethyldextran-coated (ferucarbotran, Resosvist®) and dextran-coated (ferumoxtran-10, Sinerem®) SPIONs caused significant C activation, while the citric acid, phosphatidylcholine, starch and chitosan-coated SPIONs had no such effect. Focusing on Resovist and Sinerem, we found Sinerem to be a stronger activator of C than Resovist, although the individual variation in 15 different human sera was substantial. Further analysis of C activation by Sinerem indicated biphasic dose dependence and significant production of C split product Bb but not C4d, attesting to alternative pathway C activation only at low doses. Consistent with the strong C activation by Sinerem and previous reports of HSRs in man, injection of Sinerem in a pig led to dose-dependent CARPA, while Resovist was reaction-free. Using nanoparticle tracking analysis, it was further determined that Sinerem, more than Resovist, displayed multimodal size distribution and significant fraction of aggregates – factors which are known to promote C activation and CARPA. Taken together, our findings offer physicochemical insight into how key compositional factors and nanoparticle size distribution affect SPION-induced CARPA, a knowledge that could lead to the development of SPIONs with improved safety profiles.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>