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( Lieke C. J. Van Den Berk ),( Bas J. H. Jansen ),( Kim G. C. Siebers Vermeulen ),( Tonnie Huijs ),( Helene Roelofs ),( Gesine Kogler ),( Carl G. Figdor ),( Ruurd Torensma ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.1
Mesenchymal Stem Cells (MSC) are quiescent and located in several vascular niches where they serve as a stem cell reservoir. When MSC are mobilized into peripheral tissues they are able to differentiate into various mesodermal cell lineages such as osteocytes, chondrocytes, and adipocytes, depending on the local micro-milieu. MSC can be tremendously expanded in vitro. This prompted us to compare the differentiation potential after short and long term expansion of two different MSC isolates, i.e. a cell type isolated from umbilical cord blood (UCB) and a cell type from bone marrow (BM). UCB-MSC maintain their proliferative properties for an extended period of time before they reach senescence. UCB-MSC and BM-MSC are both capable of differentiating towards the osteogenic lineage though expression of alkaline phosphatase (ALP) and matrix mineralization was much more pronounced in UCB-MSC. Regarding adipogenic differentiation, UCB-MSC were not able to form oil droplets upon differentiation while BM-MSC readily could. We furthermore show that long-term culture affects the differentiation potential of MSC lines from both origins. Interestingly, the ageing occurring due to long term culture does not alter the immunogenic properties of MSC.