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        J-PLUS: Identification of low-metallicity stars with artificial neural networks using SPHINX

        Whitten, D. D.,Placco, V. M.,Beers, T. C.,Chies-Santos, A. L.,Bonatto, C.,Varela, J.,Cristó,bal-Hornillos, D.,Ederoclite, A.,Masseron, T.,Lee, Y. S.,Akras, S.,Borges Fernandes, M.,Caballero, J. Springer-Verlag 2019 Astronomy and astrophysics Vol.622 No.-

        <P><I>Context.</I> We present a new methodology for the estimation of stellar atmospheric parameters from narrow- and intermediate-band photometry of the Javalambre Photometric Local Universe Survey (J-PLUS), and propose a method for target pre-selection of low-metallicity stars for follow-up spectroscopic studies. Photometric metallicity estimates for stars in the globular cluster M15 are determined using this method.</P><P><I>Aims.</I> By development of a neural-network-based photometry pipeline, we aim to produce estimates of effective temperature, <I>T</I>eff, and metallicity, [Fe/H], for a large subset of stars in the J-PLUS footprint.</P><P><I>Methods.</I> The Stellar Photometric Index Network Explorer, SPHINX, was developed to produce estimates of <I>T</I>eff and [Fe/H], after training on a combination of J-PLUS photometric inputs and synthetic magnitudes computed for medium-resolution (<I>R</I> ~ 2000) spectra of the Sloan Digital Sky Survey. This methodology was applied to J-PLUS photometry of the globular cluster M15.</P><P><I>Results.</I> Effective temperature estimates made with J-PLUS Early Data Release photometry exhibit low scatter, σ(<I>T</I>eff) = 91 K, over the temperature range 4500 < <I>T</I>eff (K) < 8500. For stars from the J-PLUS First Data Release with 4500 < <I>T</I>eff (K) < 6200, 85 ± 3% of stars known to have [Fe/H] < −2.0 are recovered by SPHINX. A mean metallicity of [Fe/H] = − 2.32 ± 0.01, with a residual spread of 0.3 dex, is determined for M15 using J-PLUS photometry of 664 likely cluster members.</P><P><I>Conclusions.</I> We confirm the performance of SPHINX within the ranges specified, and verify its utility as a stand-alone tool for photometric estimation of effective temperature and metallicity, and for pre-selection of metal-poor spectroscopic targets.</P>

      • KCI등재

        Tolerogenic Dendritic Cells Reduce Airway Inflammation in a Model of Dust Mite Triggered Allergic Inflammation

        Luciana S. Aragão-França,Viviane C. J. Rocha,Andre Cronemberger-Andrade,F. H. B. Costa,José Fernandes Vasconcelos,Daniel Abensur Athanazio,Daniela Nascimento Silva,E. S. Santos,Cássio Santana Meira,C. 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4

        Purpose: The use of tolerogenic dendritic cells (TolDCs) to control exacerbated immune responses may be a prophylactic and therapeutic option for application in autoimmune and allergic conditions. The objective of this work was to evaluate the effects of TolDC administration in a mouse model of allergic airway inflammation caused by mite extract. Methods: Mouse bone marrow-derived TolDCs were induced by incubation with granulocyte- macrophage colony-stimulating factor (GM-CSF) and dexamethasone, and then characterized by flow cytometry and cytokine production by enzyme- linked immunosorbent assay (ELISA). For the in vivo model of Blomia tropicalis-induced allergy, mice transplanted with antigen-pulsed TolDCs were sensitized intraperitoneally with B. tropicalis mite extract (BtE) adsorbed to aluminium hydroxide. After challenge by nasal administration of BtE, bronchoalveolar lavage fluid (BALF), lungs, spleen and serum were collected for analysis. Results: Induction of TolDCs was efficiently achieved as shown by low expression of major histocompatibility complex (MHC) II, programmed death-ligand (PD-L) 2 and pro-inflammatory cytokine production, and up-regulation of interleukin (IL)-10, upon LPS stimulation in vitro. Transplantation of 1 or 2 doses of BtE-pulsed TolDCs reduced the number of inflammatory cells in BALF and lungs as well as mucus deposition. Moreover, compared to saline-injected controls, TolDC-treated mice showed lower serum levels of anti-BtE immunoglobulin E (IgE) antibodies as well as reduced Gata3 and IL-4 gene expression in the lungs and decreased IFN-γ levels in the supernatant of splenocyte cultures Transplantation of TolDCs increased the percentage of the regulatory T cells in the spleen and the lungs. Conclusions: Preventive treatment with TolDCs protects against dust mite-induced allergy in a mouse model, reinforcing the use of tolerogenic dendritic cells for the management of allergic conditions.

      • SCIESCOPUSKCI등재

        Energy Requirements in Early Life Are Similar for Male and Female Goat Kids

        Bompadre, T.F.V.,Neto, O. Boaventura,Mendonca, A.N.,Souza, S.F.,Oliveira, D.,Fernandes, M.H.M.R.,Harter, C.J.,Almeida, A.K.,Resende, K.T.,Teixeira, I.A.M.A. Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.12

        Little is known about the gender differences in energetic requirements of goats in early life. In this study, we determined the energy requirements for maintenance and gain in intact male, castrated male and female Saanen goat kids using the comparative slaughter technique and provide new data on their body composition and energy efficiency. To determine the energy requirements for maintenance, we studied 21 intact males, 15 castrated males and 18 females ($5.0{\pm}0.1kg$ initial body weight (BW) and $23{\pm}5d$ of age) using a split-plot design with the following main factors: three genders (intact males, castrated males, and females) and three dry matter intake levels (ad libitum, 75% and 50% of ad libitum intake). A slaughter group included three kids, one for each nutritional plane, of each gender, and all three animals within a group were slaughtered when the ad libitum kid reached 15 kg in BW. Net energy requirements for gain were obtained for 17 intact males, eight castrated males and 15 females ($5.1{\pm}0.4kg$ BW and $23{\pm}13d$ of age). Animals were fed ad libitum and slaughtered when they reached 5, 10, and 15 kg in BW. A digestion trial was performed with nine kids of each gender to determine digestible energy, metabolizable energy and energy metabolizability of the diet. Our results show no effect of gender on the energy requirements for maintenance and gain, and overall net energy for maintenance was $205.6kJ/kg^{0.75}$ empty body weight gain (EBW) ($170.3kJ/kg^{0.75}$ BW) from 5 to 15 kg BW. Metabolizable energy for maintenance was calculated by iteration, assuming heat production equal to metabolizable energy intake at maintenance, and the result was $294.34kJ/kg^{0.75}$ EBW and $k_m$ of 0.70. As BW increased from 5 to 15 kg for all genders, the net energy required for gain increased from 9.5 to 12.0 kJ/g EBW gain (EWG), and assuming $k_g=0.47$, metabolizable energy for gain ranged from 20.2 to 25.5 kJ/g EWG. Our results indicate that it is not necessary to formulate diets with different energetic content for intact male, castrated male and female Saanen goat kids weighing from 5 to 15 kg.

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