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Tyrosinase inhibitory flavonoid from <i>Juniperus communis</i> fruits
Jegal, Jonghwan,Park, Sang-a,Chung, KiWung,Chung, Hae Young,Lee, Jaewon,Jeong, Eun Ju,Kim, Ki Hyun,Yang, Min Hye Informa UK (TaylorFrancis) 2016 Bioscience, biotechnology, and biochemistry Vol.80 No.12
<P>The fruits of Juniperus communis have been traditionally used in the treatment of skin diseases. In our preliminary experiment, the MeOH extract of J. communis effectively suppressed mushroom tyrosinase activity. Three monoflavonoids and five biflavonoids were isolated from J. communis by bioassay-guided isolation and their inhibitory effect against tyrosinase was evaluated. According to the results of all isolates, hypolaetin 7-O--xylopyranoside isolated from J. communis exhibited most potent effect of decreasing mushroom tyrosinase activity with an IC50 value of 45.15M. Further study provided direct experimental evidence for hypolaetin 7-O--D-xylopyranoside-attenuated tyrosinase activity in -MSH-stimulated B16F10 murine melanoma cell. Hypolaetin 7-O--D-xylopyranoside from the EtOAc fraction of J. communis was also effective at suppressing -MSH-induced melanin synthesis. This is the first report of the enzyme tyrosinase inhibition by J. communis and its constituent. Therapeutic attempts with J. communis and its active component, hypolaetin 7-O--D-xylopyranoside, might be useful in treating melanin pigmentary disorders.</P>
Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress
Jegal, K. H.,Ko, H. L.,Park, S. M.,Byun, S. H.,Kang, K. W.,Cho, I. J.,Kim, S. C. Springer Science + Business Media 2016 Apoptosis Vol.21 No.5
<P>Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) has many pharmacological activities including anti-inflammation, anti-oxidant and anti-cancer effects. Autophagy is the basic cellular machinery involving the digestion of damaged cellular components. In the present study, we investigated the protection effects of eupatilin against arachidonic acid (AA) and iron-induced oxidative stress in HepG2 cells and tried to elucidate the molecular mechanisms responsible. Eupatilin increased cell viability against AA + iron in a concentration-dependent manner and prevented mitochondrial dysfunction and reactive oxygen species (ROS) production. In addition, AA + iron increased the levels of pro-apoptotic proteins and these changes were prevented by eupatilin. Eupatilin also induced autophagy, as evidenced by the accumulation of microtubule-associated protein 1 light chain3-II and the detection of autophagic vacuoles. Furthermore, the protective effects of eupatilin on mitochondrial dysfunction and ROS production were significantly abolished by autophagy inhibitors. Eupatilin also increased the mRNA level of sestrin-2 and its promoter-driven reporter gene activity, which resulted in the up-regulation of sestrin-2 protein. Finally, gene silencing using sestrin-2 siRNA and the ectopic expression of recombinant adenoviral sestrin-2 indicated that sestrin-2 induction by eupatilin was required for autophagy-mediated cytoprotection against AA + iron. Our results suggest that eupatilin activates sestrin-2-dependent autophagy, thereby preventing oxidative stress induced by AA + iron.</P>
The Utility of a Three-Dimensional Approach with T-Shaped Osteotomy in Osseous Genioplasty
Jegal, Jung Jae,Kang, Seok Joo,Kim, Jin Woo,Sun, Hook Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.4
Background Facial beauty depends on the form, proportion, and position of various units of the face. In terms of the frontal view and facial profile, the chin is the most prominent aesthetic element of the lower third of the face. Many methods have been implemented to obtain good proportions of the lower face. In this study, we applied the T-shaped genioplasty method to correcting chin deformities. Methods All of the procedures in 9 cases were performed under general anesthesia. For genioplasty, a horizontal cutting line and 1 or 2 vertical cutting lines were drawn 5 mm below the mental foramen. Osteotomed bone segments of the chin were used for horizontal widening using bone grafts or for horizontal shortening. Likewise, they were used as bone grafts for vertical lengthening or vertical shortening. The bone segments were approximated in the midline and held in place using miniplates. Results The postoperative appearance of the 9 cases showed that the lower third of the face had been naturally changed. At the same time, vertical lengthening or shortening, and horizontal widening or shortening could be implemented during the operation. Satisfactory results were obtained based on reviews of the patients' preoperative and postoperative photographs. The patients were also satisfied with the outcomes. Conclusions Using T-shaped genioplasty, we efficiently adjusted the shape and position of the chin to obtain good proportions of the lower face and change its contour to obtain an aesthetically appealing oval face in accordance with East Asians' aesthetic preferences.
Jegal, J. H.,Choi, G. H.,Lee, H. J.,Kim, K. D.,Lee, S. C. THE POLYMER SOCIETY OF KOREA 2016 Macromolecular Research Vol.24 No.1
<P>We describe a novel approach for surface engineering of titanium (Ti) with polymer nanoparticles that can sustainably release an osteogenic compound, simvastatin (SV). The SV-loaded nanoparticles (SV-GC-CA) were prepared by self-assembly of 5 beta-cholanic acid-conjugated glycol chitosan (GC-CA) in the presence of SV. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) analyses showed that the SV-GC-CA nanoparticles had a hydrodynamic diameter of 371.4 nm with a spherical shape. The surface engineering of Ti was performed by pre-treatment of Ti surface with polydopamine (PD) coatings, followed by immobilization of the SV-GC-CA nanoparticles. The immobilization of the SV-GC-CA nanoparticles onto PD-treated Ti surfaces could be achieved by a simple dipping method in an aqueous solution. The successful immobilization of the SV-GC-CA nanoparticles onto Ti surfaces was confirmed by field-emission scanning electron microscopy (FE-SEM), and the density of immobilized nanoparticles could be controlled. SV was sustainably released for up to 20 days, and the release rate was dependent on the loading amount of SV. The Ti substrate functionalized with SV-releasing nanoparticles significantly promoted alkaline phosphatase (ALP) activity of osteoblast-like cells (MC3T3-E1). The surface engineering approach described in this work has an applicability for various medical devices to generate surfaces with improved osteogenic potentials.</P>
Physiology Is a Stronger Predictor of Survival than Pathology in Fibrotic Interstitial Pneumonia
Jegal, Yangjin,Kim, Dong Soon,Shim, Tae Sun,Lim, Chae-Man,Do Lee, Sang,Koh, Younsuck,Kim, Woo Sung,Kim, Won Dong,Lee, Jin Seong,Travis, William D.,Kitaichi, Masanori,Colby, Thomas V. American Thoracic Society 2005 American journal of respiratory and critical care Vol.171 No.6
<P>The histopathologic pattern provides the most important prognostic marker for idiopathic interstitial pneumonia; however, studies have suggested that short-term changes in lung function may be more important. We investigated the prognostic factors for fibrotic interstitial pneumonia. The clinical features and follow-up course of 179 patients (131 with idiopathic pulmonary fibrosis and 48 with nonspecific interstitial pneumonia; 41 fibrotic types and 7 cellular) were analyzed retrospectively. The lung function indices improved or stabilized in most patients with fibrotic nonspecific interstitial pneumonia in contrast to the deterioration or stable condition of most patients with idiopathic pulmonary fibrosis. The 5-year survival of patients with fibrotic nonspecific interstitial pneumonia (76.2%) was better than for those with idiopathic pulmonary fibrosis (43.8%) (p = 0.007). Multivariate analysis at the time of presentation revealed that pathologic pattern, age, and diffusion capacity had important prognostic implications. However, after 6 months of follow-up, changes in FVC, initial diffusion capacity, and sex were the only independent prognostic factors, with no additional prognostic information conferred by the histologic diagnosis. Our data confirmed the importance of physiological parameters including short-term change in FVC. However, at the time of diagnosis, histopathology was important for the prediction of prognosis and future change in lung function.</P>
Jegal, Jong-Pil,Kim, Kwang-Bum Elsevier 2013 Journal of Power Sources Vol.243 No.-
<P><B>Abstract</B></P> <P>Carbon nanotube-embedding LiFePO<SUB>4</SUB> is synthesized via a solution-based two-step method. The embedded carbon nanotubes are found to improve electron and ion transfer, resulting in excellent high rate capability. An electrode of the nanocomposite, prepared without additional conducting agent, delivers a discharge capacity of 165 mAh g<SUP>−1</SUP> at 0.1 C, 120 mAh g<SUP>−1</SUP> at 30 C, and 78 mAh g<SUP>−1</SUP> at 120 C, based on the weight of LiFePO<SUB>4</SUB>. Furthermore, the discharge curve at a discharge rate of 60 C retains the potential plateau above 3.0 V.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CNTs embedded within LiFePO<SUB>4</SUB> allows for high electronic conductivity. </LI> <LI> Cross-linked CNT imparts interconnected pore structure to the electrode. </LI> <LI> It shows excellent rate capability up to 100 C without additional conducting agent. </LI> <LI> Discharge capacity at 60 C was mainly obtained from the plateau retained above 3.0 V. </LI> </UL> </P>