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Mizutani, Akiko,Inoko, Hidetoshi,Tanaka, Masafumi Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.10
We have identified 88 interactor candidates for human growth hormone (GH) by the yeast two-hybrid assay. Among those, we focused our efforts on carboxypeptidase E (CPE), which has been thought to play a key role in sorting prohormones, such as pro-opiomelanocortin (POMC), to regulated secretory vesicles. We found that CPE colocalizes with and interacts with GH in AtT20 pituitary cells. Downregulation of CPE led to decreased levels of GH secretion, consistent with involvement of CPE in GH sorting/secretion. Our binding assay in vitro with bacterially expressed proteins suggested that GH directly interacts with CPE but in a manner different from POMC.
Akiko Mizutani,Hidetoshi Inoko,Masafumi Tanaka 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.10
We have identified 88 interactor candidates for human growth hormone (GH) by the yeast two-hybrid assay. Among those, we focused our efforts on carboxypeptidase E (CPE), which has been thought to play a key role in sorting prohormones, such as pro-opiomelanocortin (POMC), to regulated secretory vesicles. We found that CPE co-localizes with and interacts with GH in AtT20 pituitary cells. Downregulation of CPE led to decreased levels of GH secretion, consistent with involvement of CPE in GH sorting/secretion. Our binding assay in vitro with bacterially expressed proteins suggested that GH directly interacts with CPE but in a manner different from POMC.
Horie, Yukihiro,Meguro, Akira,Kitaichi, Nobuyoshi,Lee, Eun Bong,Kanda, Atsuhiro,Noda, Kousuke,Song, Yeong Wook,Park, Kyung Sook,Namba, Kenichi,Ota, Masao,Inoko, Hidetoshi,Mizuki, Nobuhisa,Ishida, Susu Oxford University Press ; Distributed by Mercury I 2012 Rheumatology Vol.51 No.6
<P>Beh?et's disease is one of the major aetiologies of uveitis causing blindness in Asian countries. A genome-wide association study identified six microsatellite markers as disease susceptibility loci for Japanese patients with Beh?et's disease. To confirm our recent results, these microsatellite markers were examined in a Korean population as a replication study.</P>