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Haiyoung Son,Hak Min Lee,Yun-Jung Yang,Hyun Jo Youn,Jong Won Lee,Jihyoun Lee,So Youn Jung,Min Hyuk Lee,Ilkyun Lee 한국유방암학회 2020 Journal of Breast Disease Vol.8 No.2
Purpose: This study aimed to investigate and analyze the current fertility-related practices for breast cancer patients; the results are intended to help improve the quality of life of young patients and survivors. Methods: This study collected voluntary responses to a questionnaire that was used to survey Korean breast cancer specialists. The questionnaire consisted of five categories: knowledge, practice behaviors regarding fertility preservation, barriers to discussing fertility preservation, attitude toward fertility issues, and demographics and medical background. Results: A total of 120 copies of the questionnaire were distributed; the response rate was 89%. The section of the questionnaire regarding knowledge indicated that most respondents had adequate fertility preservation knowledge for cancer patients. However, 13.1% of the respondents indicated that they thought pregnancy increased the cancer recurrence risk. Respondents’ knowledge and attitudes about fertility preservation were not correlated with actual practice. The absence of patient’s expressions (24.30%), high recurrence risk (27.10%), insufficient time in the clinic (21.50%), and hospital conditions such as no reproductive specialists or infertility clinic (16.82%), were considered major barriers to discussing fertility issues. Conclusion: Although more than 50% of the respondents thought that cancer treatment is more important than fertility preservation and it is complex and difficult, the Korean breast surgical oncologists were generally encouraging when discussing fertility issues with young breast cancer patients. Hence, breast clinicians should share with young patients the updated evidence regarding the feasibility and safety of pregnancy after cancer treatment and the available options so that the best decisions can be made.
Im, Ilkyun,Jang, Mi-jin,Park, Seung Ju,Lee, Sang-Hee,Choi, Jin-Ho,Yoo, Han-Wook,Kim, Seyun,Han, Yong-Mahn American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.49
<P>A defective mitochondrial respiratory chain complex (DMRC) causes various metabolic disorders in humans. However, the pathophysiology of DMRC in the liver remains unclear. To understand DMRC pathophysiology <I>in vitro</I>, DMRC-induced pluripotent stem cells were generated from dermal fibroblasts of a DMRC patient who had a homoplasmic mutation (m.3398T→C) in the mitochondrion-encoded NADH dehydrogenase 1 (<I>MTND1</I>) gene and that differentiated into hepatocytes (DMRC hepatocytes) <I>in vitro</I>. DMRC hepatocytes showed abnormalities in mitochondrial characteristics, the NAD<SUP>+</SUP>/NADH ratio, the glycogen storage level, the lactate turnover rate, and AMPK activity. Intriguingly, low glycogen storage and transcription of lactate turnover-related genes in DMRC hepatocytes were recovered by inhibition of AMPK activity. Thus, AMPK activation led to metabolic changes in terms of glycogen storage and lactate turnover in DMRC hepatocytes. These data demonstrate for the first time that energy depletion may lead to lactic acidosis in the DMRC patient by reduction of lactate uptake via AMPK in liver.</P>
고종민 ( Jongmin Ko ),양일권 ( Ilkyun Yang ),이진기 ( Jingi Lee ),유인협 ( Inhyeob Yu ),김선익 ( Sunic Kim ) 한국정보처리학회 2006 한국정보처리학회 학술대회논문집 Vol.13 No.2
전력산업이 공급자중심에서 고객중심의 비즈니스 서비스산업으로 변함에 따라 고객의 요구충족을 위한 고기능 전력정보서비스의 필요성이 점차적으로 증대되고 있다. 또한 검침데이터 단순제공에서 정보, 지식 등 특화된 분석정보 제공은 필수불가결한 요소가 되고 있다. 따라서 현재 적극적으로 추진되고 있는 전력부가서비스 시스템 개발에 효과적으로 활용될 수 있으며 고객서비스를 한 차원 높이기 위한 전략적인 시스템이 필요하다 하겠다. 본 논문은 원격검침 고압고객을 대상으로 대용량 검침데이터(168억 Point/년, 12만 고객 15분 전력사용량)의 실시간 처리기능과 다양한 전력정보(고객기본정보, 15분 전력사용량 분석정보, 전력수요누적정보, 부하지속정보 등)를 인터넷을 통해 제공하는 고객마케팅 서비스 기반을 위한 통합관리시스템 구축 연구를 수행하였고 이를 소개한다
고객마케팅 서비스 기반을 위한 전력검침데이터의 실시간 통합관리시스템 개발
고종민(JongMin Ko),이진기(JinGi Lee),유인협(InHyeob Yu),양일권(IlKyun Yang),조선구(SunGu Jo),김선익(SunIc Kim) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7
전력산업이 공급자중심에서 고객중심의 비즈니스 서비스산업으로 변함에 따라 고객의 요구충족을 위한 고기능 전력정보서비스의 필요성이 점차적으로 증대되고 있다. 또한 검침데이터 단순제공에서 정보, 지식 등 특화된 분석정보 제공은 필수불가결한 요소가 되고 있다. 따라서 현재 적극적으로 추진되고 있는 전력부가서비스 시스템 개발에 효과적으로 활용될 수 있으며 고객서비스를 한 차원 높이기 위한 전략적인 시스템이 필요하다 하겠다. 본 논문은 원격검침 고압고객을 대상으로 대용량 검침데이터 (168억 Point/년, 12만 고객 15분 전력사용량)의 실시간 처리기능과 다양한 전력정보(고객기본정보, 15분 전력사용량 분석정보, 전력수요누적정보, 부하지속정보 등)를 인터넷을 통해 제공하는 고객마케팅 서비스 기반을 위한 통합관리시스템 구축 연구를 수행하였고 이를 소개한다.
Haiyoung Son,Hyun Jun Hong,Jegyu Ryu,Jeong Won Lee,Ra Gyoung Yoon,Ilkyun Lee 대한갑상선-내분비외과학회 2016 The Koreran journal of Endocrine Surgery Vol.16 No.1
Papillary thyroid carcinoma (PTC) is commonly accompanied by cervical lymph nodemetastasis, whereas metastases to the retropharyngeal lymph nodes (RPN) are rare.Radioactive iodine (RAI) ablation is recommended for detection and treatment ofdifferentiated thyroid carcinoma (DTC). However, in some cases of iodine-negative DTC,F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography(PET/CT) can aid in detection of additional lesions. We report on a patient with PTC whohad retropharyngeal node involvement with iodine-negative features and lowthyroglobulin level at the time of diagnosis but with metastasis identified on FDG PET/CT.
Enhanced SMAD1 Signaling Contributes to Impairments of Early Development in CFC-iPSCs.
Han, Kyu-Min,Kim, Seung-Kyoon,Kim, Dongkyu,Choi, Jung-Yun,Im, Ilkyun,Hwang, Kyu-Seok,Kim, Cheol-Hee,Lee, Beom Hee,Yoo, Han-Wook,Han, Yong-Mahn AlphaMed Press 2015 Stem Cells Vol.33 No.5
<P>Cardio-facio-cutaneous (CFC) syndrome is a developmental disorder caused by constitutively active ERK signaling manifesting mainly from BRAF mutations. Little is known about the role of elevated ERK signaling in CFC syndrome during early development. Here, we show that both SMAD1 and ERK signaling pathways may contribute to the developmental defects in CFC syndrome. Induced pluripotent stem cells (iPSCs) derived from dermal fibroblasts of a CFC syndrome patient (CFC-iPSCs) revealed early developmental defects in embryoid body (EB) development, β-catenin localization, and neuronal differentiation. Both SMAD1 and ERK signalings were significantly activated in CFC-iPSCs during EB formation. Most of the β-catenin was dissociated from the membrane and preferentially localized into the nucleus in CFC-EBs. Furthermore, activation of SMAD1 signaling recapitulated early developmental defects in wild-type iPSCs. Intriguingly, inhibition of SMAD1 signaling in CFC-iPSCs rescued aberrant EB morphology, impaired neuronal differentiation, and altered β-catenin localization. These results suggest that SMAD1 signaling may be a key pathway contributing the pathogenesis of CFC syndrome during early development.</P>