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RISS 인기검색어
- 검색키워드
- 저자 : Ikeda Katsuhisa (검색결과 2 건)
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Shori Tajima,Keiko Danzaki,Katsuhisa Ikeda,Kazusaku Kamiya 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Age-related hearing loss (ARHL) is the progressive, bilateral loss of high-frequency hearing in elderly people. Mutations in GJB2, encoding the cochlear gap junction protein connexin26 (Cx26), are the most frequent cause of hereditary deafness; however, a common molecular pathology between ARHL and GJB2-related hearing loss has not been reported. Here, we investigated the quantitative change in expression and molecular pathology of Cx26 in ARHL. We used C57BL/6J mice as a model of ARHL. Hearing levels that were evaluated by auditory brainstem response thresholds increased gradually between 4 and 32 weeks of age and increased sharply at 36 weeks. Gap junctions in the cochleae of 4-week-old mice had linear plaques along cell–cell junction sites. In contrast, the cochleae from 32-weekold mice had significantly shorter gap junctions. Severe hair cell loss was not observed during this period. Based on western blotting, Cx26 and connexin30 (Cx30) levels were significantly decreased at 32 weeks compared with 4 weeks. Moreover, Cx26 was more significantly enriched in the hydrophilic fraction at 4 weeks but was more significantly enriched in the hydrophobic fraction at 32 weeks, indicating an age-related conversion of this biochemical property. Thus, the hydrophobic conversion of Cx26 and disruption of gap junction proteins and plaques may be involved in the pathogenesis of ARHL and may occur before severe hair cell degeneration.
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Hoshina Takunari,Fujiyama Daiki,Koike Takuji,Ikeda Katsuhisa 대한청각학회 2022 Journal of Audiology & Otology Vol.26 No.3
Background and Objectives: The harmful effects of frequent exposure to loud sounds through portable music players (PMPs) in combination with earphones have been suggested to result in a high prevalence of recreational noise-induced hearing loss among children, adolescents, and young adults. The present study aimed to evaluate the effects of an active noise control technology applied to earphones on the preferred listening levels (PLLs) while listening to music in the presence of background noise. Subjects and Methods: Twenty-three adults between 20 and 40 years with normal hearing were recruited for this study. PLLs for listening to pop-rock and classical music were measured in the participants’ ear canal with a commercially available PMP for four earphone/headphone configurations in quiet and noisy conditions. Ear canal insertion loss was measured in open ear conditions as well as earphone/headphone conditions. Results: The average PLL while using earphones and headphones exceeded 85 dBA corresponding to the sound level to induce hearing damage, but in the case of canal earphones with noise cancelling (NC), it was below 75 dBA, corresponding to potentially harmful levels. The background subway noise significantly increased the PLL measured in quiet conditions using any four earphone/headphone types except canal earphones with NC. Canal earphones with NC showed the lowest PLLs compared with participants’ average PLLs using the other three earphone/headphone types. Conclusions: To minimize recreational noise exposure at the risk of PMP use, the use of earphones with NC is recommended in noisy environments.
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