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Induction of P3NS1 Myeloma Cell Death and Cell Cycle Arrest by Simvastatin and/or γ-Radiation
Abdelrahman, Ibrahim Y,Helwa, Reham,Elkashef, Hausein,Hassan, Nagwa HA Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
The present study was conducted to investigate the effect of ${\gamma}$-radiation alone or combined with a cytotoxic drug, simvastatin, on viability and cell cycling of a myeloma cell line. P3NS1 myeloma cells were treated with the selected dose of simvastatin ($0.1{\mu}M/l$) 24 hours prior to ${\gamma}$-irradiation (0.25, 0.5 and 1Gy). The cell viability, induction of apoptosis, cell death, cell cycling, generation of ROS, and expression of P53, Bax, Bcl2, caspase3, PARP1 and Fas genes were estimated. The results indicated that simvastatin ($0.1{\mu}M/l$) treatment for 24 hours prior to ${\gamma}$-irradiation increased cell death to 37.5% as compared to 4.81% by radiation (0.5Gy) alone. It was found that simvastatin treatment before irradiation caused arrest of cells in G0/G1 and G2/M phases as assessed using flow cytometry. Interestingly, simvastatin treatment of P3NS1 cells increased the intracellular ROS production and decreased antioxidant enzyme activity with increased P53, Bax and Caspase3 gene expression while that of Bcl2 was decreased. Consequently, our results indicated that pre-treatment with simvastatin increased radio sensitivity of myeloma tumor cells in addition to apoptotic effects through an intrinsic mitochondrial pathway.
Yousef A. Alessi,Ibrahim Ali,Mashhour A. Alazwari,Khalid Almitani,Alaa A Abdelrahman,Mohamed A. Eltaher Techno-Press 2023 Advances in aircraft and spacecraft science Vol.10 No.2
This article presents a numerical analysis to investigate the natural frequencies and harmonic response of a perforated cantilever beam attached to two layers of piezoelectric materials by using the finite element method for the first time. The bimorph piezoelectric is composed of 3 layers; two of them at the outer are piezoelectric, and the inner isotropic material. A higher order 3-D 20-node solid element that exhibits quadratic displacement behavior is exploited to discretize the isotropic layer, and coupled piezoelectric 3D element with twenty nodes is used to mesh the top and bottom layers. CIRCU94 element is added to act as a resistor part of the model. The proposed model is validated with previous works. The numerical parametric studies are presented to illustrate the effects of perforation geometry, the number of rows, the resistance on the natural frequencies, frequency response, and power. It is found that the thickness has a positive relationship with the natural frequency. Perforations help in producing higher voltage, and the best shape is rectangular perforations, and to produce higher voltage, two rows of rectangular perforations should be applied.
Fake News Detector using Machine Learning Algorithms
Diaa Salama,yomna Ibrahim,Radwa Mostafa,Abdelrahman Tolba,Mariam Khaled,John Gerges,Diaa Salama International Journal of Computer ScienceNetwork S 2024 International journal of computer science and netw Vol.24 No.7
With the Covid-19(Corona Virus) spread all around the world, people are using this propaganda and the desperate need of the citizens to know the news about this mysterious virus by spreading fake news. Some Countries arrested people who spread fake news about this, and others made them pay a fine. And since Social Media has become a significant source of news, .there is a profound need to detect these fake news. The main aim of this research is to develop a web-based model using a combination of machine learning algorithms to detect fake news. The proposed model includes an advanced framework to identify tweets with fake news using Context Analysis; We assumed that Natural Language Processing(NLP) wouldn't be enough alone to make context analysis as Tweets are usually short and do not follow even the most straightforward syntactic rules, so we used Tweets Features as several retweets, several likes and tweet-length we also added statistical credibility analysis for Twitter users. The proposed algorithms are tested on four different benchmark datasets. And Finally, to get the best accuracy, we combined two of the best algorithms used SVM ( which is widely accepted as baseline classifier, especially with binary classification problems ) and Naive Base.
Haroun, Riham Abdel-Hamid,Zakhary, Nadia Iskandar,Mohamed, Mohamed Ragaa,Abdelrahman, Abdelrahman Mohamed,Kandil, Eman Ibrahim,Shalaby, Kamal Ali Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10
Background: Methylation of tumor suppressor genes has been investigated in all kinds of cancer. Tumor specific epigenetic alterations can be used as a molecular markers of malignancy, which can lead to better diagnosis, prognosis and therapy. Therefore, the aim of this study was to evaluate the association between gene hypermethylation and expression of fragile histidine triad (FHIT), glutathione S-transferase P1 (GSTP1) and p16 genes and various clinicopathologic characteristics in primary non-small cell lung carcinomas (NSCLC). Materials and Methods: The study included 28 primary non-small cell lung carcinomas, where an additional 28 tissue samples taken from apparently normal safety margin surrounding the tumors served as controls. Methylation-specific polymerase chain reaction (MSP) was performed to analyze the methylation status of FHIT, GSTP1 and p16 while their mRNA expression levels were measured using a real-time PCR assay with SYBR Green I. Results: The methylation frequencies of the genes tested in NSCLC specimens were 53.6% for FHIT, 25% for GSTP1, and 0% for p16, and the risk of FHIT hypermethylation increased among patients with NSCLC by 2.88, while the risk of GSTP1 hypermethylation increased by 2.33. Hypermethylation of FHIT gene showed a highly significant correlation with pathologic stage (p<0.01) and a significant correlation with smoking habit and FHIT mRNA expression level (p<0.05). In contrast, no correlation was observed between the methylation of GSTP1 or p16 and smoking habit or any other parameter investigated (p>0.05). Conclusions: Results of the present study suggest that methylation of FHIT is a useful biomarker of biologically aggressive disease in patients with NSCLC. FHIT methylation may play a role in lung cancer later metastatic stages while GSTP1 methylation may rather play a role in the early pathogenesis.
Abdalla El Azab,Ahmed Abd Elbary,Aly El Faqeh M. Okasha,Hatem Aboulkassem,Ashraf Saad Zaghloul,Riham Mohamed Karkeet,Ibrahim Abdelrahman 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.6
Purpose: The clinical effect of neoadjuvant intravesical instillation of chemotherapy immediately before transurethral resection of bladder tumors (TURBT) has been a subject of recent research. The aim of this study was to assess the effect of immediate neoadjuvant electromotive instillation of mitomycin C before transurethral resection for patients with non-muscle-invasive urothelial bladder cancer. Materials and Methods: Our study was a randomized clinical trial carried out on 50 patients diagnosed with non-muscle-invasive urothelial bladder cancer. Patients were classified into two groups: Group I consisted of 25 patients who received neoadjuvant electromotive drug administration of mitomycin C before TURBT and intravesical bacille Calmette–Guerin (BCG) per week for 6 weeks; Group II consisted of 25 patients who were treated with TURBT followed by intravesical BCG per week for 6 weeks alone (standard of care). Patients were followed up at 3, 6, 12, and 18 months by cystoscopy. Results: Patients who received neoadjuvant electromotive drug administration of mitomycin C before TURBT in combination with BCG had a low recurrence rate compared with those who received BCG alone (12.0% vs. 48.0%, respectively; p=0.012) and a longer disease-free interval (88.0% vs. 52.0%, respectively; p=0.012). Four patients developed progression to muscle-invasive disease (16.0%) in the BCG alone group. However, this difference was not statistically significant (p=0.516). Regarding adverse effects, there were no statistically significant differences between the groups. Conclusions: Neoadjuvant intravesical electromotive drug administration of mitomycin C before TURBT is safe; reduces recurrence rates and enhances the disease-free interval compared with TURBT followed by BCG alone.