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Yeon, Jihye,Kim, Jinmahn,Kim, Do-Young,Kim, Hyunmin,Kim, Jungha,Du, Eun Jo,Kang, KyeongJin,Lim, Hyun-Ho,Moon, Daewon,Kim, Kyuhyung Public Library of Science 2018 PLoS biology Vol.16 No.6
<▼1><P>Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements. However, the molecular mechanisms underlying proprioception are not fully understood. Here, we identify two transient receptor potential cation (TRPC) channels, <I>trp-1</I> and <I>trp-2</I>, as necessary and sufficient for proprioceptive responses in <I>C</I>. <I>elegans</I> head steering locomotion. Both channels are expressed in the SMDD neurons, which are required and sufficient for head bending, and mediate coordinated head steering by sensing mechanical stretches due to the contraction of head muscle and orchestrating dorsal head muscle contractions. Moreover, the SMDD neurons play dual roles to sense muscle stretch as well as to control muscle contractions. These results demonstrate that distinct locomotion patterns require dynamic and homeostatic modulation of feedback signals between neurons and muscles.</P></▼1><▼2><P><B>Author summary</B></P><P>Proprioception provides the nervous system with feedback about body posture in animals and is essential for the generation of coherent locomotive behaviors, such as walking, running, or crawling. However, little is known about the identity of proprioceptive receptors that sense body movement to regulate locomotion and the extent to which proprioception modulates sensorimotor coordination. Here, we analyze the molecular mechanisms that control head steering locomotion of <I>Caenorhabditis elegans</I>. We show that this movement is regulated by the transient receptor potential cation (TRPC) channels TRP-1 and TRP-2 and the SMDD proprioceptive neurons. We observe that mutant animals for both channels are defective in head steering locomotion and that ectopic expression of TRP-1 or TPR-2 in a <I>C</I>. <I>elegans</I> chemosensory neuron confers head bending–dependent responses, suggesting roles for these channels in proprioception. We also find that SMDD neurons are both necessary and sufficient to generate head steering locomotion via the two channels. Moreover, we demonstrate that the proprioceptive system mediates locomotion coordination by desynchronizing activities in motor systems. We conclude that two TRPC channels in collaboration with the proprioceptive receptor SMDD neurons control head steering in worms during forward locomotion.</P></▼2>
Kim, Hyunmin,Ha, Yumi,Kwon, Ki Hyuk,Kang, Minju,Kim, Nack J.,Lee, Sunghak Elsevier 2015 Acta materialia Vol.87 No.-
<P><B>Abstract</B></P> <P>In this study, the Charpy impact toughness of three austenitic high-Mn steels was evaluated at room and cryogenic temperatures, and interpreted by deformation mechanisms in relation to the microstructural evolution of dynamically compressed specimens. Under dynamic compressive loading, nanocell structures composed of subgrains were formed by the reaction with twins and dislocations, and resulted in a high-strain-rate deformation mechanism that enhanced the strength, ductility and toughness within the stacking fault energy (SFE) range of the twinning-induced plasticity (TWIP) mechanism at room temperature. At cryogenic temperature, the formation of nanocell structures was activated with increasing Mn content, which showed the opposite trend to the room-temperature case. Since the cryogenic-temperature SFEs were lower by ∼30% than the room-temperature SFEs, a considerable amount of ε-martensite was formed in the 0.4C–22Mn steel by the transformation-induced plasticity (TRIP) mechanism, while the TWIP mechanism was working, thereby leading to increased Charpy toughness compared to the 0.4C–24Mn and 0.4C–26Mn steels. The Charpy impact toughness results were discussed using a new schematic diagram of deformation mechanisms based on SFE, loading condition and test temperature.</P>
Hyunmin Kim,Sungkyun Cho 국제무예학회 2020 International Journal of Martial Arts Vol.6 No.-
In Children are in the stages of development in emotion and decision making, so it is hard for them to make decisions and enroll in sports institutes by themselves. In most cases, decisions on enrollment in private institutions are made by the expectations and supports of parents. Hence, the aim of this study is to explore the influence of the intrinsic participation motivation of parents who are educating their children in private sports institute on their children’s behavioral change and decision of continuing education also, to providing the results as a basic data for vitalization of the sports institutes.For analyses, researchers conducted frequency analysis, EFA, internal consistency analysis, correlation analysis, and multiple regression analysis by SPSS Windows ver. 23.0. Firstly, the intrinsic participation motivation has significant effect to children’s behavioral change. Secondly, the behavioral change of children has significant effects to the decision of education continuity. Thirdly, the intrinsic participation motivation has significant effect on the decision of education continuity.The research results show the necessities of education program revision for holding current students and getting new student. For instance, the instructors’ qualifications, various education programs and the quality of education environments are must be revised and improved based on “All Care System”. Moreover, it is necessary to seek the ways to satisfy children’s psychological and physical health, joyfulness and sense of accomplishment, and have to accumulate data to show the changes of children to the parents.
Hyunmin Kim,Seung Yeon Noh,Se Hwan Kwon,Hyun-Min Ko,Hyung Joon Ahn,Joo Hyeong Oh 대한영상의학회 2023 대한영상의학회지 Vol.84 No.5
Pseudoaneurysms are among the most serious complications of percutaneous balloon angioplasty. Although pseudoaneurysm rupture rarely happens, when it does, the result can be fatal; thus, early detection and management are crucial. In this report, we disclose the case of a 34-year-old male with end-stage renal disease who presented with a huge symptomatic pseudoaneurysm of the left popliteal artery, following percutaneous balloon angioplasty three months prior. The pseudoaneurysm was successfully excluded using interventional treatment. The patient recovered well, and the followup was uneventful, with excellent patency of the covered stent.
Kim, Sang Kyu,Cho, Hyunmin,Park, Hyun Kyu,Kim, Joong Hyun,Chung, Bong Hyun American Scientific Publishers 2010 Journal of Nanoscience and Nanotechnology Vol.10 No.1
<P>We report a new approach to fabricate nanochannels on silicon-on-insulator (SOI) wafers using conventional micromachining techniques. Proper selection of the size of the photomask-window and the thickness of the top silicon layer is necessary to obtain nano-sized regions. Silicon anisotropic wet etching followed by an additional reactive-ion-etching (RIE) process and a second silicon wet etching step resulted in long channels (1 cm) of about 200 nm width and 100 nm depth. Finally, we demonstrated the ability of the nanochannels to stretch random coiled DNA by applying YOYO-1 stained lamda-DNA to the nanochannel sealed by PDMS polymer using fluorescence microscopy. This fabrication method provides a basis for simple and cost-effective mass production of nanochannels with controllable dimensions. It is therefore expected that the nanochannels fabricated have great potential for biological applications.</P>
The structural basis of eukaryotic chaperonin TRiC/CCT: Action and folding
Hyunmin Kim,Junsun Park,Soung-Hun Roh Korean Society for Molecular and Cellular Biology 2024 Molecules and cells Vol.47 No.3
Accurate folding of proteins in living cells often requires the cooperative support of molecular chaperones. Eukaryotic group II chaperonin Tailless complex polypeptide 1-Ring Complex (TRiC) accomplishes this task by providing a folding chamber for the substrate that is regulated by an Adenosine triphosphate (ATP) hydrolysis-dependent cycle. Once delivered to and recognized by TRiC, the nascent substrate enters the folding chamber and undergoes folding and release in a stepwise manner. During the process, TRiC subunits and cochaperones such as prefoldin and phosducin-like proteins interact with the substrate to assist the overall folding process in a substrate-specific manner. Coevolution between the components is supposed to consult the binding specificity and ultimately expand the substrate repertoire assisted by the chaperone network. This review describes the TRiC chaperonin and the substrate folding process guided by the TRiC network in cooperation with cochaperones, specifically focusing on recent progress in structural analyses.
A Review on Types of Induction Melter in Radioactive Treatment Waste Facilities
HyunMin Kim,JunKi Baik,SukWon Jung,GangWoo Ryu 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
The type of radioactive waste that may occur in the process of nuclear power plant dismantling can be classified into solid, liquid, gas, and mixed waste. The amount of these wastes must be defined in the Final Decommissioning Plan for approval of the licensing. Also, in the case of Metal radioactive waste, it is necessary to calculate the generation amount in order to treat radioactive waste at a Radioactive Waste Treatment Facility (RWTF). Since a large quantity of metal radioactive waste is generated during the decommissioning of a nuclear power plant, the application of a metal melter for reduction is considered. The metal waste is heated to a temperature above the melting point and separated into liquid and gas forms. Nuclides existing on the surface of metal waste vaporize in a melting furnace to become dust or collect in sludge. Nonvolatile nuclides such as Co, Fe and Mn remain in ingot, but other nuclides can be captured and reduced with dust and sludge. And the types of melting furnaces to be applied can be broadly classified into Atmospheric Induction Melter (AIM) and Vacuum Induction Melter (VIM). Therefore, this review intends to compare the two types of metal furnaces to be included in RWTF.