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( Hyeonseok Ko ),( Sun-joong Kim ),( So Hee Shim ),( Hyoihl Chang ),( Chang Hoon Ha ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.5
Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used against a variety of diseases, including cancer, in Eastern Asia. Here we determined that shikonin inhibits proliferation of gastric cancer cells by inducing apoptosis. Shikonin’s biological activity was validated by observing cell viability, caspase 3 activity, reactive oxygen species (ROS) generation, and apoptotic marker expressions in AGS stomach cancer cells. The concentration range of shikonin was 35-250 nM with the incubation time of 6 h. Protein levels of Nrf2 and p53 were evaluated by western blotting and confirmed by real-time PCR. Our results revealed that shikonin induced the generation of ROS as well as caspase 3-dependent apoptosis. c-Jun-N-terminal kinases (JNK) activity was significantly elevated in shikonin-treated cells, thereby linking JNK to apoptosis. Furthermore, our results revealed that shikonin induced p53 expression but repressed Nrf2 expression. Moreover, our results suggested that there may be a co-regulation between p53 and Nrf2, in which transfection with siNrf2 induced the p53 expression. We demonstrated for the first time that shikonin activated cell apoptosis in AGS cells via caspase 3- and JNK-dependent pathways, as well as through the p53-Nrf2 mediated signal pathway. Our study validates in partly the contribution of shikonin as a new therapeutic approaches/ agent for cancer chemotherapy.
HyeonSeok Jang,Young Min Kim,Jin-Do Chung,Kwon Soon Lee 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
Since the eco-era is getting closer, the importance of noise reducing in the passenger cars of high-speed train is very important. The active noise is best choice to reduce low frequency noise because since the passive one too heavy for high speed trains where weight so critical. Also ANC able to reduce the ambient noise when the environmentalfactor changes. To reduce a three-dimensional closed-space sound field like a car of a high-speed rail is hard to do using single channel ANC control system.
Hyeonseok Oh,Daeun Yu,Yoon-Ho Choi,Namgi Kim 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.11
With advancements in network technologies, network virtualization has been proposed to efficiently provide a large number of services and flexible management by utilizing limited resources over existing networks as much as possible. Network virtualization has been proposed as a new paradigm for networks, as it simplifies complicated network configurations for convenient maintenance through the maximum utilization of limited network resources. However, problems have arisen due to network virtualization, such as how to assign real network components that are compatible with virtual network components over a large number of virtual machines existing in a network. In particular, the service-chaining concept—where a network flow only passes through needed services—has been newly introduced by combining the recently highlighted Software-Defined Network with a virtualization concept called Network Function Virtualization. As a result, studies on which virtual machines are selected and how to connect them have increased ever more. Accordingly, this paper aims to identify virtual machines that are compatible with service chaining in a virtual network environment where virtual machines are dispersed, and it proposes a method of how to create a path by connecting virtual machines.
Hyeonseok Choi,Jaeseung Joo,Tae Sung Cheong 한국방재학회 2017 Journal of Disaster Management Vol.2 No.3
A large scaled rainfall simulator had constructed by the National Disaster Management Research Institute (NDMI) in 2016 to help for designing the disaster risk reduction measures with experimental study. It was comprised of 288 nozzles and it had the size of 30m each length and 12m of height, which can be generated 250mm/h rainfall intensity at most. In order to verify the developed simulator, two types of test were performed such as for evaluating total rainfall amounts and spatial distributions of raindrops. The Christiansen Uniformity Coefficients (CuC) was used to evaluate the uniformity of raindrops, which is one of the significant parameter to assure the similarity to the real rainfall. As a result, CuC showed around 80% above, which means that the developed simulator has high operational reliability. Thus, it will be fully functional for drainage model experiment or hydraulic structure design contributing to the flood disaster risk reduction.